KEGG   Rattus norvegicus (rat): 24848
Entry
24848             CDS       T01003                                 
Symbol
Tph1
Name
(RefSeq) tryptophan 5-hydroxylase 1
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00380  Tryptophan metabolism
rno00790  Folate biosynthesis
rno01100  Metabolic pathways
rno04726  Serotonergic synapse
Module
rno_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    24848 (Tph1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    24848 (Tph1)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    24848 (Tph1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     24848 (Tph1)
SSDB
Motif
Pfam: Biopterin_H ACT TH_ACT ACT_4 zf-C2HE DUF262
Other DBs
NCBI-GeneID: 24848
NCBI-ProteinID: NP_001094104
RGD: 3895
Ensembl: ENSRNOG00000011672
UniProt: P09810 A6JBC3
Position
1:complement(106293695..106314628)
AA seq 444 aa
MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCAN
RVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRE
LNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVAC
KQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSA
MNELRHDLDVVNDALARVSRWPSV
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgattgaagacaacaaggagaacaaagaccattcctcagaaagggggagagtgactctc
atcttttccttgaagaatgaagttggaggactcataaaagcactgaaaatcttccaggag
aaccacgtgaacctgttacatattgagtcccggaaatcgaagcgaagaaactcagaattt
gagatttttgtggactgcgacatcaaccgagaacagctgaatgacatctttcccctgctg
aagtcccacaccacggtcctctctgtggactcgcccgatcagctccctgaaaaggaagat
gttatggagactgtcccttggttcccaaagaagatttctgacctggacttctgcgccaac
agagtgctgttgtacggatccgaactcgacgcggaccatcctggcttcaaagacaatgtc
taccgtagaagacgaaagtatttcgcagagctggctatgaactacaaacatggggacccc
attcccaagattgaattcacggaagaggagattaagacctgggggaccatcttccgagag
ctgaacaaactctacccaacccacgcctgcagggagtacctcagaaaccttcctctgctc
tcaaaatactgtggctatcgggaagacaacgtcccgcaactggaagatgtctccaacttt
ttaaaagaacgcacagggttttccatccgtcctgtggctggttacctctcaccgagagat
ttcctgtcagggttagcctttcgagtctttcactgcactcagtatgtgagacacagttcg
gatcctctctataccccagagccagacacctgccacgaactcttaggccacgtccctctc
ttggctgaacccagttttgctcaattctcccaagaaattggcctggcttctcttggagct
tcagaggagacggttcagaaactggcaacgtgctacttcttcactgtggagtttggactg
tgcaagcaagatgggcagctgagagtctttggtgccggcctgctttcttccatcagtgag
ctcagacatgcactttctggacatgccaaggttaagccctttgatcccaaggttgcctgc
aaacaggaatgtctcatcacaagcttccaggatgtctactttgtatcggagagctttgaa
gatgcaaaggagaagatgagagaatttgccaaaaccgtgaagcgcccgtttggagtgaag
tacaatccgtacacacagagcattcaggttctgagagacagcaagagcataaccagcgcc
atgaatgagttgcggcatgacctcgatgtcgtcaatgatgcccttgctagagtcagcagg
tggcccagtgtgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
Protein domain (6)   
   Pfam (6)   
All databases (51)   

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