KEGG   Rattus norvegicus (rat): 25022
Entry
25022             CDS       T01003                                 
Symbol
Fgfr2
Name
(RefSeq) fibroblast growth factor receptor 2 isoform b
  KO
K05093  fibroblast growth factor receptor 2 [EC:2.7.10.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno04010  MAPK signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04020  Calcium signaling pathway
rno04144  Endocytosis
rno04151  PI3K-Akt signaling pathway
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04810  Regulation of actin cytoskeleton
rno05200  Pathways in cancer
rno05215  Prostate cancer
rno05226  Gastric cancer
rno05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    25022 (Fgfr2)
   04014 Ras signaling pathway
    25022 (Fgfr2)
   04015 Rap1 signaling pathway
    25022 (Fgfr2)
   04020 Calcium signaling pathway
    25022 (Fgfr2)
   04151 PI3K-Akt signaling pathway
    25022 (Fgfr2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    25022 (Fgfr2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    25022 (Fgfr2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    25022 (Fgfr2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    25022 (Fgfr2)
   05230 Central carbon metabolism in cancer
    25022 (Fgfr2)
  09162 Cancer: specific types
   05226 Gastric cancer
    25022 (Fgfr2)
   05215 Prostate cancer
    25022 (Fgfr2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    25022 (Fgfr2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    25022 (Fgfr2)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:rno04090]
    25022 (Fgfr2)
   00536 Glycosaminoglycan binding proteins [BR:rno00536]
    25022 (Fgfr2)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     25022 (Fgfr2)
Protein kinases [BR:rno01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   25022 (Fgfr2)
CD molecules [BR:rno04090]
 Proteins
  25022 (Fgfr2)
Glycosaminoglycan binding proteins [BR:rno00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   25022 (Fgfr2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase I-set Ig_3 ig Ig_2 V-set Ig_5 ABC1 Ig_4 C2-set_2 V-set_CD47 CBM9_1 Kinase-like Pkinase_fungal
Other DBs
NCBI-GeneID: 25022
NCBI-ProteinID: NP_001103362
RGD: 2611
Ensembl: ENSRNOG00000016374
UniProt: Q63237 F1LNW0 Q63240 Q63236
Position
1:complement(194175703..194280914)
AA seq 840 aa
MGLPSTWRYGTGPGIGTVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEPPTK
YQISQPEACVVAPGESLELRCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD
SGLYACAAARTVDSETLYFMVNVTDAISSGDDEDDTDSSEDFVSENRSNQRAPYWTNTEK
MEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV
VPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVY
SDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYT
CLAGNSIGISFHSAWLTVLPAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMK
TTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA
GVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKD
DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP
PGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK
IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG
SPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL
TLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYDPCLPQYPHINGSVKT
NT seq 2523 nt   +upstreamnt  +downstreamnt
atgggattaccgtccacatggagatatggaacaggaccagggattggcaccgtgaccatg
gtcagctgggggcgcttcatctgcctggtcttggtcaccatggcaaccttgtccctggcc
cggccctccttcagtttagttgaagataccactttagaaccagaagagccaccaaccaaa
taccaaatctcccaaccagaagcgtgcgtggttgcccccggggagtcgctagagttgcgc
tgcatgttgaaagatgccgccgtgatcagttggactaaggatggggtgcacttggggccc
aacaataggacagtgcttattggggagtacctccagataaaaggtgccacacctagagac
tccggcctctatgcttgtgctgcagctaggacggtagacagtgaaactttgtacttcatg
gtgaatgtcacagatgccatctcatctggagatgacgaggacgacacagatagctccgaa
gactttgtcagtgagaacaggagcaaccagagagcaccgtactggaccaacaccgaaaag
atggagaagcggctccatgctgtccctgccgccaacactgtgaagttccgctgtccagcc
ggggggaatccaacacccacaatgaggtggctaaaaaacgggaaggagtttaagcaggag
catcgcatcggaggctataaggtacgaaaccagcactggagccttattatggaaagtgtg
gtcccatcagacaaaggcaattacacctgcctggtggagaatgaatacgggtccatcaac
cacacctaccaccttgatgttgttgagcgatcaccacaccggcccatcctccaagctgga
ctgcctgcaaatgcctccacggtggtcggaggggacgtagaatttgtctgcaaggtttat
agtgatgcccagccccatatccagtggatcaaacatgtggaaaagaacggcagtaaatat
ggacctgatgggctgccctacctcaaggtcctgaaggccgccggtgttaacaccacggac
aaagaaattgaggttctctatattcggaatgtaacttttgaggatgctggggaatatacg
tgcttggcgggtaattctatcgggatatcctttcactctgcatggttgacagttctgcca
gcacctgtgagagagaaggagatcacagcttccccagattacctggagatagctatttac
tgcataggggtcttcttaatcgcctgcatggtggtgacagtcatcttttgccgaatgaag
accacgaccaagaagccagacttcagcagccagccagctgtgcacaagctgaccaagcgc
atccccctgcggagacaggtaacagtttcggccgagtccagctcgtccatgaactccaac
accccactggtgaggataacgacacgtctgtcctcaacggcggacaccccgatgctagca
ggggtctctgagtacgagttgccagaggatccaaagtgggaattccccagagataagctg
acgctgggcaaacccctgggggaaggctgcttcgggcaagtagtcatggctgaagcggtg
ggaatcgataaggacagacccaaggaggcagtcaccgtggcggtgaagatgttgaaagat
gacgccacagagaaggacctgtctgacctggtgtcagagatggagatgatgaagatgatt
ggtaaacataagaacatcatcaacctcctgggggcctgcacccaggatggacccctctat
gtcatagtcgaatacgcatcgaaaggcaacctccgggaatacctccgggcccggaggcca
cctggcatggagtactcctatgacattaaccgagttcccgaggagcagatgaccttcaag
gacttggtgtcctgcacctaccagctggcgagaggcatggagtacttggcttcccaaaaa
tgtatccatcgagacttggcagccagaaatgtgctggtaacagaaaacaacgtgatgaag
atagcagactttggcctggccagggatatcaacaacatagactattacaaaaagaccacg
aatgggcgacttccagtcaagtggatggctcctgaagccctttttgatagagtttacact
catcagagtgatgtctggtccttcggggtgttaatgtgggagatcttcactttagggggt
tcaccctacccagggattcccgtggaggaactttttaagctgctcaaagagggccacagg
atggacaagcccaccaactgcaccaatgaactgtacatgatgatgagggactgctggcat
gctgtaccctcacagaggcccacgtttaagcagttggtggaagacttggatcgaattctg
actctcacaaccaatgaggaatacttggacctcacccagcctctcgaacagtattctcct
agttaccccgacacaaggagctcttgttcttcaggggacgattctgtgttttctccagac
cccatgccttatgacccctgcctgcctcagtatccacacataaacggcagtgttaaaaca
tga

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (13)   
   KEGG PATHWAY (13)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (29)   
   UniProt (4)   
   RefSeq(pep) (25)   
DNA sequence (67)   
   RefSeq(nuc) (25)   
   GenBank (21)   
   EMBL (21)   
Protein domain (15)   
   Pfam (15)   
All databases (137)   

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