KEGG   Rattus norvegicus (rat): 25023
Entry
25023             CDS       T01003                                 
Symbol
Prkcb
Name
(RefSeq) protein kinase C beta type isoform 2
  KO
K19662  classical protein kinase C beta type [EC:2.7.11.13]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04020  Calcium signaling pathway
rno04062  Chemokine signaling pathway
rno04064  NF-kappa B signaling pathway
rno04066  HIF-1 signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04071  Sphingolipid signaling pathway
rno04150  mTOR signaling pathway
rno04270  Vascular smooth muscle contraction
rno04310  Wnt signaling pathway
rno04370  VEGF signaling pathway
rno04510  Focal adhesion
rno04540  Gap junction
rno04613  Neutrophil extracellular trap formation
rno04650  Natural killer cell mediated cytotoxicity
rno04662  B cell receptor signaling pathway
rno04666  Fc gamma R-mediated phagocytosis
rno04670  Leukocyte transendothelial migration
rno04713  Circadian entrainment
rno04720  Long-term potentiation
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04727  GABAergic synapse
rno04728  Dopaminergic synapse
rno04730  Long-term depression
rno04750  Inflammatory mediator regulation of TRP channels
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04916  Melanogenesis
rno04918  Thyroid hormone synthesis
rno04919  Thyroid hormone signaling pathway
rno04921  Oxytocin signaling pathway
rno04925  Aldosterone synthesis and secretion
rno04928  Parathyroid hormone synthesis, secretion and action
rno04929  GnRH secretion
rno04931  Insulin resistance
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04935  Growth hormone synthesis, secretion and action
rno04960  Aldosterone-regulated sodium reabsorption
rno04961  Endocrine and other factor-regulated calcium reabsorption
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno04973  Carbohydrate digestion and absorption
rno05017  Spinocerebellar ataxia
rno05022  Pathways of neurodegeneration - multiple diseases
rno05031  Amphetamine addiction
rno05032  Morphine addiction
rno05140  Leishmaniasis
rno05143  African trypanosomiasis
rno05146  Amoebiasis
rno05161  Hepatitis B
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05207  Chemical carcinogenesis - receptor activation
rno05214  Glioma
rno05223  Non-small cell lung cancer
rno05225  Hepatocellular carcinoma
rno05231  Choline metabolism in cancer
rno05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    25023 (Prkcb)
   04012 ErbB signaling pathway
    25023 (Prkcb)
   04014 Ras signaling pathway
    25023 (Prkcb)
   04015 Rap1 signaling pathway
    25023 (Prkcb)
   04310 Wnt signaling pathway
    25023 (Prkcb)
   04370 VEGF signaling pathway
    25023 (Prkcb)
   04064 NF-kappa B signaling pathway
    25023 (Prkcb)
   04066 HIF-1 signaling pathway
    25023 (Prkcb)
   04020 Calcium signaling pathway
    25023 (Prkcb)
   04070 Phosphatidylinositol signaling system
    25023 (Prkcb)
   04071 Sphingolipid signaling pathway
    25023 (Prkcb)
   04150 mTOR signaling pathway
    25023 (Prkcb)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    25023 (Prkcb)
   04540 Gap junction
    25023 (Prkcb)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    25023 (Prkcb)
   04650 Natural killer cell mediated cytotoxicity
    25023 (Prkcb)
   04662 B cell receptor signaling pathway
    25023 (Prkcb)
   04666 Fc gamma R-mediated phagocytosis
    25023 (Prkcb)
   04670 Leukocyte transendothelial migration
    25023 (Prkcb)
   04062 Chemokine signaling pathway
    25023 (Prkcb)
  09152 Endocrine system
   04911 Insulin secretion
    25023 (Prkcb)
   04929 GnRH secretion
    25023 (Prkcb)
   04912 GnRH signaling pathway
    25023 (Prkcb)
   04921 Oxytocin signaling pathway
    25023 (Prkcb)
   04935 Growth hormone synthesis, secretion and action
    25023 (Prkcb)
   04918 Thyroid hormone synthesis
    25023 (Prkcb)
   04919 Thyroid hormone signaling pathway
    25023 (Prkcb)
   04928 Parathyroid hormone synthesis, secretion and action
    25023 (Prkcb)
   04916 Melanogenesis
    25023 (Prkcb)
   04925 Aldosterone synthesis and secretion
    25023 (Prkcb)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    25023 (Prkcb)
  09154 Digestive system
   04970 Salivary secretion
    25023 (Prkcb)
   04971 Gastric acid secretion
    25023 (Prkcb)
   04972 Pancreatic secretion
    25023 (Prkcb)
   04973 Carbohydrate digestion and absorption
    25023 (Prkcb)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    25023 (Prkcb)
   04961 Endocrine and other factor-regulated calcium reabsorption
    25023 (Prkcb)
  09156 Nervous system
   04724 Glutamatergic synapse
    25023 (Prkcb)
   04727 GABAergic synapse
    25023 (Prkcb)
   04725 Cholinergic synapse
    25023 (Prkcb)
   04728 Dopaminergic synapse
    25023 (Prkcb)
   04726 Serotonergic synapse
    25023 (Prkcb)
   04720 Long-term potentiation
    25023 (Prkcb)
   04730 Long-term depression
    25023 (Prkcb)
   04723 Retrograde endocannabinoid signaling
    25023 (Prkcb)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    25023 (Prkcb)
  09159 Environmental adaptation
   04713 Circadian entrainment
    25023 (Prkcb)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    25023 (Prkcb)
   05206 MicroRNAs in cancer
    25023 (Prkcb)
   05205 Proteoglycans in cancer
    25023 (Prkcb)
   05207 Chemical carcinogenesis - receptor activation
    25023 (Prkcb)
   05231 Choline metabolism in cancer
    25023 (Prkcb)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    25023 (Prkcb)
   05214 Glioma
    25023 (Prkcb)
   05223 Non-small cell lung cancer
    25023 (Prkcb)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    25023 (Prkcb)
   05161 Hepatitis B
    25023 (Prkcb)
   05171 Coronavirus disease - COVID-19
    25023 (Prkcb)
   05164 Influenza A
    25023 (Prkcb)
   05163 Human cytomegalovirus infection
    25023 (Prkcb)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    25023 (Prkcb)
   05140 Leishmaniasis
    25023 (Prkcb)
   05143 African trypanosomiasis
    25023 (Prkcb)
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    25023 (Prkcb)
   05022 Pathways of neurodegeneration - multiple diseases
    25023 (Prkcb)
  09165 Substance dependence
   05031 Amphetamine addiction
    25023 (Prkcb)
   05032 Morphine addiction
    25023 (Prkcb)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    25023 (Prkcb)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    25023 (Prkcb)
   04933 AGE-RAGE signaling pathway in diabetic complications
    25023 (Prkcb)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    25023 (Prkcb)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    25023 (Prkcb)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     25023 (Prkcb)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   25023 (Prkcb)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C Kinase-like ABC1 CEP76-C2
Other DBs
NCBI-GeneID: 25023
NCBI-ProteinID: NP_001165776
RGD: 3396
Ensembl: ENSRNOG00000012061
UniProt: P68403
Structure
Position
1:186263397..186594743
AA seq 671 aa
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGL
GLQGFQSQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE
LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
NT seq 2016 nt   +upstreamnt  +downstreamnt
atggctgacccggctgcggggccgccgccgagcgagggcgaggagagcacggtgcgcttc
gcccgcaaaggcgccctccggcagaagaacgtgcacgaggtgaagaaccacaaattcacc
gcccgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatttggggctta
ggtttgcagggattccagagtcaggtctgctgctttgttgtacacaagcgctgccatgaa
ttcgtcacgttctcctgccctggtgcagacaagggcccggcctctgatgacccacggagc
aaacacaagtttaagatccacacctactccagccctaccttctgtgaccactgtggatca
ctgctgtatgggctcatccaccaggggatgaaatgcgacacctgtatgatgaatgtccac
aagcgctgcgtgatgaacgtccccagcctctgtggcaccgaccacacagaacgccgtggc
cgcatctacatccaggcccacatcgacagggaggtcctcatcgttgttgtaagagatgct
aaaaatctggtacctatggaccccaacggcttgtcagatccctacgtaaaactgaaactg
atccctgatcccaaaagtgagagcaagcagaagaccaagactatcaaatgctccctcaac
ccggagtggaacgaaaccttcagatttcagctgaaggaatcagacaaagacagaagactg
tccgtagagatctgggattgggacctgaccagcaggaatgacttcatgggatctctgtcg
tttgggatttcagaactacagaaagccggagtggatggctggttcaagttactaagccag
gaagaaggcgagtactttaatgtgccggtgccgccggaaggaagcgagggcaatgaagag
ctgcggcagaagtttgagagagccaagattggccaaggtaccaaggctccagaagaaaag
acagcgaacactatatccaaatttgacaacaatggcaacagggaccggatgaaactgacc
gattttaacttcctgatggtgctggggaaaggcagctttggcaaggtcatgctctcagag
cggaagggtacagatgaactctatgccgtgaagatcctgaagaaagatgtggtgatccaa
gatgacgatgtggagtgcacaatggtggagaagagggtgctggccctgcctgggaagccc
ccattcctgactcagctccattcctgcttccagaccatggaccgcctctactttgtgatg
gagtatgtgaacgggggcgacctcatgtaccacatccaacaagttggccgtttcaaggag
ccccatgctgtattttacgctgcagagattgccatcggtcttttcttcttgcagagcaag
ggcatcatttaccgtgacctgaaacttgacaacgtgatgctggattccgaggggcacatc
aaaatcgctgactttggcatgtgtaaagagaatatctgggatggggtgacaaccaagaca
ttctgtggcactccagactacattgccccagagatcattgcttatcagccctacgggaag
tctgtggactggtgggcgtttggagtcctgctgtatgaaatgttggctggccaggcacct
tttgaaggggaggatgaggatgaactcttccagtcaatcatggagcacaacgtggcgtat
cccaagtccatgtctaaggaagctgtggcaatctgcaaagggctaatgaccaaacaccca
ggcaagcgcctgggttgtgggcctgaaggggaacgagacattaaggagcatgcatttttc
cggtatatcgactgggagaaactcgaacgcaaggagattcagccaccttataaaccaaaa
gctagagacaagcgagacacctccaacttcgacaaagagttcaccaggcagcctgtggaa
ctgactcccactgacaaactcttcatcatgaacttggaccaaaatgaatttgctggcttc
tcgtatactaacccagagtttgtcattaatgtgtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (71)   
   KEGG PATHWAY (71)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (33)   
   RefSeq(nuc) (5)   
   GenBank (14)   
   EMBL (14)   
3D Structure (2)   
   PDB (2)   
Protein domain (8)   
   Pfam (8)   
All databases (132)   

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