KEGG   Rattus norvegicus (rat): 25400
Entry
25400             CDS       T01003                                 
Symbol
Camk2a
Name
(RefSeq) calcium/calmodulin-dependent protein kinase type II subunit alpha
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04012  ErbB signaling pathway
rno04020  Calcium signaling pathway
rno04024  cAMP signaling pathway
rno04066  HIF-1 signaling pathway
rno04114  Oocyte meiosis
rno04148  Efferocytosis
rno04217  Necroptosis
rno04261  Adrenergic signaling in cardiomyocytes
rno04310  Wnt signaling pathway
rno04360  Axon guidance
rno04713  Circadian entrainment
rno04720  Long-term potentiation
rno04722  Neurotrophin signaling pathway
rno04725  Cholinergic synapse
rno04728  Dopaminergic synapse
rno04740  Olfactory transduction
rno04750  Inflammatory mediator regulation of TRP channels
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04916  Melanogenesis
rno04921  Oxytocin signaling pathway
rno04922  Glucagon signaling pathway
rno04925  Aldosterone synthesis and secretion
rno04934  Cushing syndrome
rno04971  Gastric acid secretion
rno05012  Parkinson disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05031  Amphetamine addiction
rno05152  Tuberculosis
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05214  Glioma
rno05415  Diabetic cardiomyopathy
rno05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    25400 (Camk2a)
   04310 Wnt signaling pathway
    25400 (Camk2a)
   04066 HIF-1 signaling pathway
    25400 (Camk2a)
   04020 Calcium signaling pathway
    25400 (Camk2a)
   04024 cAMP signaling pathway
    25400 (Camk2a)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    25400 (Camk2a)
  09143 Cell growth and death
   04114 Oocyte meiosis
    25400 (Camk2a)
   04217 Necroptosis
    25400 (Camk2a)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    25400 (Camk2a)
   04922 Glucagon signaling pathway
    25400 (Camk2a)
   04912 GnRH signaling pathway
    25400 (Camk2a)
   04921 Oxytocin signaling pathway
    25400 (Camk2a)
   04916 Melanogenesis
    25400 (Camk2a)
   04925 Aldosterone synthesis and secretion
    25400 (Camk2a)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    25400 (Camk2a)
  09154 Digestive system
   04971 Gastric acid secretion
    25400 (Camk2a)
  09156 Nervous system
   04725 Cholinergic synapse
    25400 (Camk2a)
   04728 Dopaminergic synapse
    25400 (Camk2a)
   04720 Long-term potentiation
    25400 (Camk2a)
   04722 Neurotrophin signaling pathway
    25400 (Camk2a)
  09157 Sensory system
   04740 Olfactory transduction
    25400 (Camk2a)
   04750 Inflammatory mediator regulation of TRP channels
    25400 (Camk2a)
  09158 Development and regeneration
   04360 Axon guidance
    25400 (Camk2a)
  09159 Environmental adaptation
   04713 Circadian entrainment
    25400 (Camk2a)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    25400 (Camk2a)
   05205 Proteoglycans in cancer
    25400 (Camk2a)
  09162 Cancer: specific types
   05214 Glioma
    25400 (Camk2a)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    25400 (Camk2a)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    25400 (Camk2a)
   05022 Pathways of neurodegeneration - multiple diseases
    25400 (Camk2a)
  09165 Substance dependence
   05031 Amphetamine addiction
    25400 (Camk2a)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    25400 (Camk2a)
   05415 Diabetic cardiomyopathy
    25400 (Camk2a)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    25400 (Camk2a)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    25400 (Camk2a)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     25400 (Camk2a)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   25400 (Camk2a)
SSDB
Motif
Pfam: Pkinase CaMKII_AD PK_Tyr_Ser-Thr DUF4440 SnoaL_3 SnoaL_2 APH Kdo SnoaL_4
Other DBs
NCBI-GeneID: 25400
NCBI-ProteinID: NP_037052
RGD: 2261
Ensembl: ENSRNOG00000018712
UniProt: P11275 A6IXE8
Structure
Position
18:56648779..56711505
AA seq 478 aa
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
NT seq 1437 nt   +upstreamnt  +downstreamnt
atggctaccatcacctgcacccgattcacggaagagtaccagctcttcgaggaactggga
aagggagccttctccgtggtgcgcaggtgtgtgaaggtgctggctggccaggagtatgct
gccaagattatcaacaccaagaagctctcagccagagatcaccagaagttggaacgcgag
gcccgcatctgccgcttgttgaagcaccccaatatcgtccgactccatgacagcatctcc
gaggaggggcaccactaccttatcttcgatctggtcactggtggggagctgttcgaagac
attgtggcccgggagtattacagtgaggctgatgccagccactgtatccagcagatcctg
gaggctgtgctacactgtcaccagatgggggtggtgcatcgcgacctgaagcctgagaat
ctgttgctggcttcgaagctcaagggtgctgcggtgaagctggcagactttggcctggcc
atagaggttgagggagagcagcaggcatggtttgggttcgcagggacacctggatacctc
tccccagaagtgctgcggaaggacccatacgggaagcctgtggacctgtgggcctgtggc
gtcatcctgtatatcttgctggttgggtatcccccattctgggatgaggaccagcaccgc
ctgtaccagcagatcaaagctggtgcctacgatttcccatcaccagaatgggacaccgtc
accccggaagccaaggatctgatcaataagatgctgaccatcaacccgtccaaacgcatc
acggccgctgaggctctcaagcacccctggatctcgcaccgctccactgtggcctcctgc
atgcacagacaggagaccgtggactgcctgaagaagttcaatgccaggaggaaactgaag
ggagccatcctcaccactatgctggccaccaggaacttctccggagggaagagtggagga
aacaagaagaatgatggcgtgaaggaatcctctgagagcaccaacaccaccatcgaggat
gaagacaccaaagtgcgcaaacaggaaattatcaaagtgacagagcagctgatcgaagcc
ataagcaatggagactttgaatcctacacgaagatgtgcgaccctggaatgacagccttt
gaaccggaggccctggggaacctggtcgagggcctggactttcatcgattctattttgaa
aacctgtggtcccggaacagcaagcccgtgcacaccaccatcctgaaccctcacatccac
ctgatgggtgacgagtcagcctgcatcgcctacatccgcatcactcagtacctggatgcg
ggtggcatcccccgcacggcccagtcagaggagacccgtgtctggcaccgcagggatgga
aaatggcagatcgtccacttccacagatctggggcgccctccgtcctgccccattga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (34)   
   KEGG PATHWAY (34)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (11)   
   RefSeq(nuc) (3)   
   GenBank (4)   
   EMBL (4)   
3D Structure (4)   
   PDB (4)   
Protein domain (9)   
   Pfam (9)   
All databases (75)   

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