KEGG   Rattus norvegicus (rat): 25638
Entry
25638             CDS       T01003                                 
Symbol
Pde4a
Name
(RefSeq) 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1
  KO
K13293  cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00230  Purine metabolism
rno01100  Metabolic pathways
rno04024  cAMP signaling pathway
rno04928  Parathyroid hormone synthesis, secretion and action
rno05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    25638 (Pde4a)
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    25638 (Pde4a)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    25638 (Pde4a)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    25638 (Pde4a)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.53  3',5'-cyclic-AMP phosphodiesterase
     25638 (Pde4a)
SSDB
Motif
Pfam: PDEase_I PDE4_UCR
Other DBs
NCBI-GeneID: 25638
NCBI-ProteinID: NP_037233
RGD: 3279
Ensembl: ENSRNOG00000020828
UniProt: P54748
Structure
Position
8:27966978..28029721
AA seq 844 aa
MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERSETERS
PHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDS
QASPGLVLHAGATTSQRRESFLYRSDSDYDMSPKAVSRSSSVASEAHAEDLIVTPFAQVL
ASLRSVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQL
ETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNEVEIPSPTP
RQRAFQQPPPSVLRQSQPMSQITGLKKLVHTGSLNTNVPRFGVKTDQEDLLAQELENLSK
WGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMMYMLTLEDHYHADVAYHN
SLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELAL
MYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLA
DLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFF
QQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLED
NRDWYHSAIRQSPSPPLEEEPGGLGHPSLPDKFQFELTLEEEEEEDSLEVPGLPTTEETF
LAAEDARAQAVDWSKVKGPSTTVVEVAERLKQETASAYGAPQESMEAVGCSFSPGTPILP
DVRTLSSSEEAPGLLGLPSTAAEVEAPRDHLAATRACSACSGTSGDNSAIISTPGRWGSG
GDPA
NT seq 2535 nt   +upstreamnt  +downstreamnt
atggagcctccggccgccccctcggaaaggagcctgtctctctctcttccggggccccgg
gagggccaggccaccctgaagccgcccccccagcacctgtggcggcagccgaggaccccg
atccgcatccagcaacgcggctactcggacagtgccgagcgctcagagacagagcgctca
ccgcaccggcccatagagcgcgccgacgccgtggacactggcgaccggccaggcctgcgg
actacccgcatgtcctggccctcgtccttccacggcaccggtaccggcggaggcagcagt
aggcgcttggaggcagaaaatgggccaacgccatcccctggccgcagccccctggactcg
caggcgagcccggggcttgtgctgcatgctggggccaccaccagccagcgccgcgagtcc
ttcctctaccgctcagacagcgactatgacatgtcaccgaaggctgtgtccaggagctcg
tctgtcgccagcgaagcgcacgctgaggacctcattgtgacaccatttgcccaggtgctg
gccagtctccgcagcgttcgaagcaacttctcactcttaaccaatgtgcccatccccagc
aacaagaggtctccactgggtggcccaccctctgtctgcaaggccacactgtcagaggag
acgtgccagcagctggcccgggagaccctggaagagctggattggtgcctggagcagctg
gagaccatgcagacctaccgctctgtcagcgagatggcctcacacaagttcaaaaggatg
ctgaaccgtgagctcacacacctgtcggaaatgagcaggtcaggaaaccaggtctcagag
tacatttccaacacattcctggacaagcagaatgaagtggagatcccctcacccacacct
cggcagagagccttccagcagcccccgccgtcagtgctgcgacagtcccagcccatgtct
cagatcacagggctgaaaaagctggtacacactggaagcttgaacaccaacgtcccacgg
tttggagtcaagacagatcaagaggacctcttagcacaagaactggagaacttgagcaaa
tggggcctgaacatcttttgtgtgtcggagtacgctggaggccgctcactcagctgtatc
atgtatacgatattccaggagcgggacctactgaagaaattccacatccctgtggacacc
atgatgatgtacatgctgaccctggaggaccactaccatgccgacgtggcctaccacaac
agcctgcacgcagcggatgtgctgcagtccacacacgtgctgctggccacgcccgcactg
gacgctgtgttcacagacctggagattcttgctgccctcttcgctgctgccatccacgat
gtggaccaccctggcgtctccaaccagttcctaatcaacaccaattcggagctggcgttg
atgtacaacgatgagtctgtgcttgagaaccaccacctggctgtgggattcaagctgctg
caagaagagaactgcgacatcttccagaacctcagcaagcgccagcggcagagcctgcgc
aagatggtcatcgacatggtgctggccacagacatgtccaaacacatgaccctcctggct
gacctgaagactatggtggagacgaagaaagtgaccagctccggagttctcttgctggac
aactactctgaccgtatccaggtcctcaggaacatggtgcactgtgcagacctcagcaat
cccaccaagcccctggagctgtaccgacagtggaccgaccgcatcatggctgagttcttc
cagcagggcgaccgagaacgggagcgtggaatggagatcagccccatgtgcgacaagcac
acagcctctgtggagaagtctcaggtgggcttcatcgactacattgttcatccattgtgg
gagacatgggcagatctcgtccacccggatgcccaagacatcctggacacgctggaagac
aaccgggactggtaccacagtgccattcggcagagtccttccccacccctggaagaggag
ccaggggggcttggccatccgtccctgcctgacaagttccaatttgagctcaccttggag
gaagaggaggaagaggattccttggaggttccaggattgcctaccactgaggaaaccttc
ctggctgcagaggatgccagagctcaagctgtggactggtcaaaggtcaaaggcccgagc
actacagtggtggaagtggcagagcgcttgaagcaggagaccgcctcagcatatggtgct
cctcaggagtccatggaggctgtaggctgttccttcagccctgggacccctattctgcct
gacgtgaggaccctatcctcctcagaggaggccccaggcctcctgggcctcccctccacg
gcggcagaggtggaggccccaagagaccatctggctgccacgagggcttgttctgcctgc
tctgggacctcaggagacaattctgccatcatctctactccaggcaggtgggggtcaggc
ggagaccctgcctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (33)   
   RefSeq(nuc) (15)   
   GenBank (9)   
   EMBL (9)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (72)   

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