KEGG   Rattus norvegicus (rat): 286964
Entry
286964            CDS       T01003                                 
Symbol
Hsd17b6
Name
(RefSeq) 17-beta-hydroxysteroid dehydrogenase type 6
  KO
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00140  Steroid hormone biosynthesis
rno00830  Retinol metabolism
rno01100  Metabolic pathways
rno01240  Biosynthesis of cofactors
Module
rno_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
rno_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    286964 (Hsd17b6)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    286964 (Hsd17b6)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     286964 (Hsd17b6)
    1.1.1.105  all-trans-retinol dehydrogenase (NAD+)
     286964 (Hsd17b6)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     286964 (Hsd17b6)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR DUF1776 Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 286964
NCBI-ProteinID: NP_775427
RGD: 708343
Ensembl: ENSRNOG00000002597
UniProt: O54753
Position
7:complement(831407..850950)
AA seq 327 aa
MITAPGHSLIMWFYLVTLVGLYYLLRWYRERQVVSHLHDKYVFITGCDSGFGNLLARQLD
RRGMRVLAACLTEKGAEELKSKTSDRLETVILDVTNTDSISAATQWVKEHVGDKGLWGLV
NNAGVFQAFAYIEWCRPEDCMSIFQVNLIGLAQVTLSMLFLVKKARGRIVNVSSVLGRVA
LFGGFYSCSKYGVEAFSDVLRREIRDFGVKVSIIEPGSFKTRMTDAELIIEKTKKTWEAT
PEHIRESYGQQFFDDFCNTTRRELKKCSTNLSLVTDCMEHALTSKYPRTRYSAGWDARLF
FIPLSYLPTSLVDCLLAISRRKPAQAV
NT seq 984 nt   +upstreamnt  +downstreamnt
atgattactgctcctggacattccctcataatgtggttttacctggtgactcttgtgggc
ctttactaccttctgcgttggtatcgtgaaaggcaggtggtgagccatctacatgacaag
tatgtcttcatcacgggttgtgactctggctttgggaacctgctggccagacagctggac
aggagaggcatgagggtgctggctgcatgtctgactgagaagggagcagaggagctgaag
agcaagacatctgacaggctggagacagtgatccttgacgttaccaacacagacagtatt
tcagcagccactcagtgggtgaaggagcatgttggagacaaaggactctggggtttggtt
aataatgcaggtgtgtttcaagcatttgcctacattgagtggtgccgaccggaggactgc
atgtctatctttcaagtgaacctcattggtttggcacaggtgactctgagcatgcttttc
ctggtaaagaaggctcggggcaggatcgtcaacgtctccagtgttttgggaagagttgca
ttgtttggaggattctacagttgctccaagtatggagtcgaggcattttcggacgtgcta
agacgtgagattcgagatttcggggtgaaagtcagcataattgaacctggaagcttcaaa
acgagaatgactgacgcagagctaatcattgagaaaaccaagaaaacctgggaggcaacc
cctgagcacatcagggagtcctacggacagcagttttttgatgacttttgcaacaccacc
agacgagaactgaagaagtgcagcacgaacctgagcctggtcacagactgcatggagcac
gctctgacctctaagtatcctcgcacccgatactcagctggctgggatgccagacttttc
ttcatccctctgtcttatttgcctacatcactggtagactgcctactggccatatctagg
cgcaagccagctcaggcagtctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (21)   
   KEGG COMPOUND (21)   
Chemical reaction (14)   
   KEGG ENZYME (3)   
   KEGG REACTION (11)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (5)   
   Pfam (5)   
All databases (67)   

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