KEGG   Rattus norvegicus (rat): 288227
Entry
288227            CDS       T01003                                 
Symbol
Bace2
Name
(RefSeq) beta-secretase 2 precursor
  KO
K07747  beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:rno00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    288227 (Bace2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:rno01002]
    288227 (Bace2)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.45  memapsin 1
     288227 (Bace2)
Peptidases and inhibitors [BR:rno01002]
 Aspartic peptidases
  Family A1: pepsin family
   288227 (Bace2)
SSDB
Motif
Pfam: Asp TAXi_C TAXi_N
Other DBs
NCBI-GeneID: 288227
NCBI-ProteinID: NP_001002802
RGD: 1303241
Ensembl: ENSRNOG00000001953
UniProt: Q6IE75 A6IQF8
Position
11:50176852..50258948
AA seq 514 aa
MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGL
ALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
NT seq 1545 nt   +upstreamnt  +downstreamnt
atgggcgcgctgcttcgagcactcttgctcccactgctggcgcagtggctcttgcgcgcg
gtccccgtgctggccccggcgcccttcacgcttcccctccaagtggccggggccgcgaac
cacagagcctcaactgttcccgggctcgggacccccgagttgccccgggctgatggcctg
gccctcgcactggagcctgccagggctaccgccaacttcttggctatggtggacaatctt
cagggggactctggccgcggctactacctggagatgctgattgggacccctccgcagaag
gtacggattcttgtggacaccggaagcagtaacttcgcagtggcaggtgccccacactcc
tacatagacacctactttgactcagagagctccagcacataccactccaagggctttgag
gtcacggtgaagtacacacagggaagctggactggatttgttggtgaggaccttgtcacc
atcccaaaaggcttcaacagctctttcttggtcaatattgccactattttcgagtctgag
aatttctttttgcctgggattaagtggaatggaatccttggactcgcttatgctgccttg
gccaagccatcaagctctctggagactttttttgattccctggtggcccaagcaaaaatt
ccggacattttctccatgcagatgtgcggggctggattgccagtagctggatctggtacc
aacggaggtagtcttgtcctgggtgggattgaaccaagtttgtataaaggagatatatgg
tataccccaattaaagaggaatggtactatcaaatagagatcttgaaattggaaattgga
ggccagagcctcaacctggactgcagagagtataacgcagacaaggccattgtggacagc
ggcaccacactcctgcgcctgccccagaaggtgtttgatgcagtggtggaagccgtggca
cgcacatctctgattccagagttttctgatggcttctggacgggggcccagctggcatgc
tggacaaattctgaaactccatgggcgtatttccctaagatttctatctacctgagagat
gagaacgccagtcgctccttccgaatcaccattctgccgcagctctacattcagcccatg
atgggagctggtttcaattatgagtgctaccgttttggtatctcctcttccacaaatgcg
ctggtgattggtgccaccgtgatggagggattctacgtggtctttgacagagctcagagg
agggtgggctttgcagtgagtccctgtgcagagattgcaggtaccacagtgtctgaaatt
tctgggcccttttccacggaagacatagccagcaactgtgttccagcacaggctctgaat
gagcccatcttgtggattgtgtcctatgccctgatgagtgtgtgtggagccattctcctg
gttctgatcctcctgctgctgttcccgctgcactgccgacacgccccccgagaccctgag
gtggttaacgatgaatcctcactagtcagacatcgctggaaatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
Protein domain (3)   
   Pfam (3)   
All databases (28)   

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