KEGG   Rattus norvegicus (rat): 288259
Entry
288259            CDS       T01003                                 
Symbol
Gart
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
  KO
K11787  phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00230  Purine metabolism
rno00670  One carbon pool by folate
rno01100  Metabolic pathways
rno01523  Antifolate resistance
Module
rno_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    288259 (Gart)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    288259 (Gart)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    288259 (Gart)
Enzymes [BR:rno01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.2  phosphoribosylglycinamide formyltransferase 1
     288259 (Gart)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.1  phosphoribosylformylglycinamidine cyclo-ligase
     288259 (Gart)
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.13  phosphoribosylamine---glycine ligase
     288259 (Gart)
SSDB
Motif
Pfam: GARS_A Formyl_trans_N AIRS_C GARS_N GARS_C AIRS ATP-grasp CPSase_L_D2 ATP-grasp_3 ATP-grasp_2 ATP-grasp_4 Dala_Dala_lig_C LUD_dom
Other DBs
NCBI-GeneID: 288259
NCBI-ProteinID: NP_001011899
RGD: 1308717
Ensembl: ENSRNOG00000028292
UniProt: A6JLG8 G3V918
Position
11:complement(44351841..44377086)
AA seq 1010 aa
MAARVLVIGSGGREHTLAWKLAQSPHVKQVLVAPGNAGTASAGKISNAAVSINDHTALAR
FCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAALLESSKKFAKEFMDRHGVP
TAQWRAFTSPEDACSFIMSADFPALVVKASGLAAGKGVIVAKSKAEACEAVQEIMQEKSF
GAAGETVVVEELLEGEEVSCLCFTDGKTVAPMPPAQDHKRLLDGDRGPNTGGMGAYCPAP
QVPKDLLVKIKNTILQRTVDGMQQEGVPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTFDGLLSESPPVWLENHSAVTVVMASGGYPGAYTKGVEITGFPEA
QALGLQVFHAGTALKDAKVVTSGGRVLTVTAVRENLMSALDEARKGLAALKFEGAVYRKD
IGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTTEAVVAGIAAACRQAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERHQKLP
QLERIAEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTR
IYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPRKLGVDLDAYTWRVPKVFSWLQQEG
QLSEEEMARTFNCGVGAALVVSKDQTEQILHDIRQHQEDAWVIGSVVECPEDSPRVRVKN
LIETMQTKGSVVTNGFLRSNFPSQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLV
ISNKAAVAGLDRAERAGIPTRVINHKLYKSRVEFDNAVDHVLEEFSVDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA
VPVQRDDTVATLSERVKAAEHKIFPAALQLVASGAVQLGEDGKIHWAREQ
NT seq 3033 nt   +upstreamnt  +downstreamnt
atggcagcccgagttcttgtaatcggtagtggaggaagggaacacaccctggcctggaaa
ctcgcacaatcccctcatgtcaaacaagtgctggttgccccaggaaatgcaggcacagct
tctgctgggaagatctccaatgctgctgtctccatcaatgatcacactgctctcgctcgg
ttctgcaaagatgaaaagattgaactcgtagttgttggaccagaggcccctctggctgca
gggattgttggggacctgacttctgcaggagtgcgatgctttggccccacggcacaagca
gctctactggagtccagtaaaaagtttgccaaagagtttatggaccgacatggcgtccca
actgcacagtggcgggcattcaccagccctgaagacgcctgcagctttattatgagcgcg
gactttcctgctttggttgtgaaggccagtggccttgcagcagggaagggggtgattgtg
gcgaagagcaaagctgaagcctgcgaagctgttcaggagatcatgcaagaaaagtcattt
ggagcagccggtgaaactgttgtcgtggaggagcttctggaaggggaagaagtgtcttgc
ctgtgcttcactgatgggaagacagtggccccaatgcccccagcacaagaccataagcga
ttgctggatggagatcggggacccaacactggaggaatgggagcctactgccctgcacct
caggttcctaaggatttgttagtaaaaattaaaaacacaattcttcagagaacagtagat
ggcatgcagcaggagggggtgccgtacacaggaattctttatgctggtataatgctgacc
aaagatggcccaaaagttttggagtttaattgccgttttggtgatccagaatgccaggtc
atcctcccacttcttaaaagtgacctttatgaagtgattcagtccacctttgatggcctg
ctgagcgagtctccgcctgtttggctagaaaaccacagtgccgtaactgttgtcatggcg
agtggagggtatcctggagcctacaccaagggtgtggagattacagggtttcctgaggcc
caagctttaggactgcaggtctttcatgcaggcactgctcttaaagatgccaaagtggtg
accagcgggggcagagtcctcacagtgacagctgtccgggaaaatctcatgtcagccctt
gatgaggccaggaagggactcgctgctctaaagtttgagggagcagtttaccgaaaggac
attggcttccgtgctgtggccttcctccagcggcccaggggcctgacctacaaggactct
ggagtagacattgcagctggaaatatgctggttaagaaaattcagcctttagccaaagct
acctccagaccaggctgcagtgttgaccttgggggctttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctctggaacagacggtgttggaactaaacta
aagattgcccagctgtgcaataagcatgactccatcggtcaggatctggttgcgatgtgc
gtgaacgacatcctcgcacaaggagcagagcccctcttcttccttgactacttttcctgt
ggaaaacttgaccttagtacaactgaggctgtggttgctggaattgctgcagcttgccga
caggctgggtgtgctctcctaggtggggagacagcagagatgcccgacatgtacccccct
ggagagtatgatcttgccggatttgctgttggtgctatggagagacaccagaagctccct
cagctagaaaggatcgccgaaggagatgccgttattggagtggcttcatctggtcttcac
agcaatggctttagccttgtgaggaaaattgtggagaggtcttcactccagtactcctct
ccagcaccgggtggttgtggagatcagactttaggggacttacttctaactccaaccagg
atctacagccattcactgctgcctatcatacgttcaggacgtgtcaaagcttttgctcat
attactggaggtggattgctggaaaacatccccagagtcctccctcggaagcttggagta
gatttagatgcctatacctggagggtccccaaggtcttctcatggctacagcaagaagga
cagctctctgaagaagaaatggccaggacattcaactgtggggttggagctgccctggtg
gtatcaaaggaccaaacagagcagattctccatgacattcggcagcaccaggaagacgcc
tgggtgataggcagtgtcgttgagtgtcccgaagattcccctcgtgtcagagttaagaat
ctgattgaaaccatgcaaacaaaggggtcagtggtgacaaacggcttcctgagaagtaat
ttccctagccagcaaaagaaagcaagagtggctgtcctaatatctggaacagggtcgaac
ctccaggcactcatagacagcactcgggatccaaaaagctcctcacacatcgttcttgtc
atctccaacaaagctgcagttgctggcttagaccgagcagagcgagctggcattcccacc
agggtgattaatcataagttatataaaagtcgtgtcgagtttgacaacgcagttgaccat
gtcctggaagagttctcagtagacatagtctgtctcgcaggattcatgaggatcctctct
ggcccgtttgtcagaaaatgggatgggaaaatgctcaacatccacccgtccttgctccct
tcttttaagggttcaaatgctcacgagcaggttctggaggctggagtcaccattactggg
tgcaccgtacactttgtagctgaagacgtagatgccgggcaaatcatcctacaggaagct
gtccctgtgcagagggacgacactgttgcaacactgtctgaacgcgtcaaggcagcagaa
cataagatatttcctgcagccctccaactagtggccagtggggctgtgcagctgggagaa
gacggcaagatccactgggccagagagcagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (7)   
   KEGG ENZYME (3)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (2)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (13)   
   Pfam (13)   
All databases (57)   

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