KEGG   Rattus norvegicus (rat): 290805
Entry
290805            CDS       T01003                                 
Symbol
Wrn
Name
(RefSeq) bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
  KO
K10900  werner syndrome ATP-dependent helicase [EC:5.6.2.4]
Organism
rno  Rattus norvegicus (rat)
Brite
KEGG Orthology (KO) [BR:rno00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:rno03032]
    290805 (Wrn)
   03400 DNA repair and recombination proteins [BR:rno03400]
    290805 (Wrn)
Enzymes [BR:rno01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.4  DNA 3'-5' helicase
     290805 (Wrn)
DNA replication proteins [BR:rno03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    290805 (Wrn)
DNA repair and recombination proteins [BR:rno03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    RecQ family DNA helicases
     290805 (Wrn)
SSDB
Motif
Pfam: DNA_pol_A_exo1 DEAD Helicase_C HTH_40 RQC HRDC RecQ_Zn_bind ResIII
Other DBs
NCBI-GeneID: 290805
NCBI-ProteinID: NP_001414000
RGD: 1564788
Ensembl: ENSRNOG00000015440
Position
16:65466552..65602951
AA seq 1400 aa
METTSLRRKFPEWMSTQNKSCATQEKASIQKSVLEDDLPFLEFTGSVVYSYEASDCSFLS
EDISMHLSDGDVVGFDMEWPPIYKQGKRSRVAVIQLCVSESKCYLFHISSMSVFPQGLKM
LLENKSIRKAGVGIEGDQWKLLRDFDVKLESFVELTDVANRKLKCAETWSLNGLVKHVLG
KQLLKDKSIRCSNWSDFPLSEDQKLYAATDAYAGLIIYQKLENLGDAVQVFALNKAEESL
PMEMKKQLNSISEEMRDLANHFPVTCRNLETLQRVPMILENISENLCSLRKVICASTDTG
TKLEPGGGSHLLSSEGSAAVGEKEKQMGEHRTFPKIKEEAWDPELDSLVKHEAVDVFRKQ
VKQEKGGFEDEMEDSLLREVMERTCLMPSISEYDLQDLEQQAKEEKHNAISHQFSEHLSP
DDDEKDSSYIIESDEDLEMEMLKSLENLNSDVGEPTHSKWLETGGSVNLPPEEEDGDGKE
AFEEEQEEEDHLLPEPNAKQINCLKTYFGHCSFKPVQWKVIHSVLEERRDNVVVMATGYG
KSLCFQYPPVYTGKIGIVISPLISLMEDQVLQLEMSNIPACLLGSAQPKNILGDIKLGRY
RIIYITPEFCSGNLDLLQQLDSNIGITLIAVDEAHCISEWGHDFRSSFRTLGSLKTALPL
VPVIALSATASSSIREDIIRCLNLKDPHITCTGFDRPNLYLEVERKTGNILQDLKPFLVR
KTSSAWEFEGPTIIYCPSRKVTEQVTVELGKLNVACQAYHAGMKISERKDIHHRFLRDEI
QCVVATIAFGMGINKADIRKVIHYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNT
TRNRLIEIHNEKFRLHKLKMMVKMEKYLHSSRCRRQIILSHFEDKRLQKASLAVMGTEKC
CDNCRPRLNHCSSANNSEDTAQDFGPQAFQLLSAVDILQEKFGIKIPILFLRGSNSQRLP
EKYHNHRLFGAGKEQAESWWKALSHHLIAEGFLVEVPKQNKFIKTCSLTKKGRKWLGEAI
LQSPPSLVLQADEEAFSRKALLSSSNPVSSETKPHSSNQKPTGSSTQQSNLEGAYSDKVP
EKFSSGSNIPKKSVVMQSPGTSYSSWEPVISAQEVDTRTVLYARLVEARQKHANEVDVPP
AVLATNKVLLDMAKMRPTTVENVKQIDGVSEGKAALLAPLTEVIKHFCQVNSVQTDLFAS
TKPQEDEEKSQEMENKACSLPQSAAVTYALFQEKKMSLHSIAENRLLPLTAVGMHLAQAV
KAGHPLDMERAGLTPETRKIIMDVIRNPPINSDMYKVKLIRMLVPENIDTYLIHMMIEIL
ESGSHGRTQPSCDSNRKRCLPSPAESCGSFKKSKEMVTETKAPSEMSQRKLPEWFVKGNV
PLAATGSSSMAKTKKKGLFS
NT seq 4203 nt   +upstreamnt  +downstreamnt
atggaaaccacttccctgcggcggaaatttccagaatggatgtcaacgcagaataaaagc
tgtgccacacaagaaaaggcaagcattcagaagagtgttcttgaagatgacctcccattc
ttagaatttactggatctgttgtttacagttatgaggccagcgattgctctttcctgtct
gaagacattagcatgcatctgtctgacggagatgtggtaggatttgacatggaatggcca
cccatatacaagcaagggaaacgaagcagagttgcagtgatccagctgtgcgtgtctgag
agcaagtgttacttgtttcacatttcttctatgtcagttttcccccaggggttaaaaatg
ttactagaaaacaaatcgattaggaaggcaggcgtgggcattgaaggggaccagtggaaa
cttctgcgtgactttgatgtcaagttggagagttttgtggagttgacagacgtcgccaac
agaaagctcaagtgcgcggagacctggagcctcaatggtctggttaaacacgtcttagga
aaacagcttttgaaagacaagtccatccgctgtagcaattggagtgatttccccctctct
gaggaccagaaactgtatgcagccactgatgcttacgctggtctcatcatctatcaaaaa
ttagaaaatttgggtgatgccgtgcaagtgtttgctctaaataaagcagaggaaagccta
cctatggagatgaagaaacagttgaattcaatctctgaagaaatgagggaccttgccaat
cattttcctgtcacttgcagaaatttggaaactctacagagggttcctatgatattggag
aacatttcagaaaatctgtgttcattgagaaaggtgatctgtgcttctacagacactggg
actaaactggagccaggcggtggttcgcatttactgtcatccgagggttcagctgctgtc
ggagagaaagagaaacaaatgggagaacacaggacttttcctaaaattaaagaagaagca
tgggacccagaacttgacagtttagtgaagcatgaggcggtcgatgttttcagaaagcaa
gtgaagcaagaaaaaggtggatttgaggatgaaatggaagacagtctgttgagagaagtt
atggaaagaacttgtttgatgccaagtatttcagaatatgacctccaagatttggaacag
caagccaaagaagaaaaacataatgctatttctcaccagttttctgagcacttatctccc
gatgatgatgagaaagactcctcttacatcattgaaagtgatgaagacttagaaatggag
atgctgaagtctttagaaaatctaaacagcgatgtgggggagcccactcattccaaatgg
ctggaaacgggaggcagtgtgaaccttcctcccgaggaggaagatggagacggaaaggaa
gccttcgaagaggagcaggaagaagaggaccatttattgccagaacccaatgcaaagcaa
attaattgcctcaagacttatttcggccactgcagttttaaaccggtccagtggaaagtc
atccattcagtattagaagaaagaagagataatgttgtcgtcatggcaactggatacgga
aagagtctgtgcttccagtatccgcccgtttatacaggcaagatcggcattgtcatttcg
ccccttatctccttaatggaagaccaggtcctccagcttgaaatgtccaacattccagcc
tgtttacttggatcagcacaaccaaaaaatattctaggagatattaaattaggcagatat
aggatcatctacataactccagagttctgttctggtaacttggacctactccagcaactt
gactctaatattggtatcacactcattgctgtggatgaggctcactgcatttctgagtgg
ggtcacgactttagaagttcattcaggactctgggctctctgaagacagcactcccactg
gttccagtcattgccctctctgctaccgcgagctcttccatccgggaagacattatacgg
tgcttaaacttgaaagaccctcacatcacctgcactgggtttgaccgacccaatctctac
ttagaagttgaacggaaaacagggaatatacttcaggatctaaagccatttctcgtccga
aagacaagttctgcctgggaattcgaaggtccaaccatcatctattgtccttcgagaaaa
gtgacagaacaagttactgttgaacttgggaaactgaatgtagcctgccaggcataccac
gccggcatgaaaattagcgaaaggaaggacattcatcataggttcctgagagatgaaatc
cagtgtgttgtagctactatagcctttggaatgggcattaataaagccgacattcgcaaa
gttattcactacggcgctcccaaggaaatggagtcctattaccaggaaatcggaagagct
ggccgtgatggacttcagagttcctgtcacttgctctgggctccagcagactttaacaca
actaggaatcgccttattgagattcacaatgaaaagttccggttacataaattaaagatg
atggtaaagatggagaaataccttcattccagtcgatgtaggcgacaaatcatcttgtcc
cattttgaggacaaacgactacagaaggcctccttggccgttatgggaactgaaaaatgc
tgtgataattgcaggcccagactgaatcattgctcttctgctaacaactcagaggataca
gcccaagactttgggccacaagcattccagctactatctgccgtggacatcctgcaggag
aaatttggaattaagatcccgattttatttctccgaggatccaattctcagcgtcttcct
gagaaatatcacaatcacaggctttttggtgctggcaaggagcaagcagagagttggtgg
aaggccctttctcaccatctcatagctgaaggattcttggtagaggttcccaagcaaaac
aaatttataaagacttgttccctcacaaaaaagggtaggaagtggcttggtgaagccatt
ttgcagtctcctcccagccttgtccttcaagctgacgaagaggcgttttcaaggaaggct
ttgctatccagttctaatcccgtatcttcagaaacgaagccacactcctctaatcaaaag
ccaactgggtcaagtacacagcagtctaatttggagggagcgtattctgacaaagtgcct
gagaaattttcttctgggagtaacattcctaaaaaaagcgtcgtgatgcagtcaccggga
acatcgtacagctcctgggaacctgtcatttcggcccaagaggtcgacacccggactgtg
ctgtatgccaggttggtggaggcacggcagaagcacgctaatgaggtggatgtacctcca
gctgtgctagcaaccaacaaggttctgctggacatggccaagatgagaccgactactgtt
gaaaacgtgaaacagattgacggtgtctccgaaggcaaagctgctctgttggcccctctg
acggaagtcatcaaacatttctgtcaagtaaatagtgttcagacagacctcttcgccagt
accaaacctcaggaggacgaggagaaaagtcaggagatggagaacaaagcctgctcactc
ccccagtctgcggccgtcacatatgctctattccaggaaaagaaaatgtccttacacagc
atagctgagaatagacttctgcctctcacagcggtcggcatgcacttagcccaggcggtg
aaagccggccaccccctggatatggagcgagctggcctgaccccagagactcggaagatt
attatggatgttatccgaaaccctcccatcaactcagatatgtataaagttaaactcatc
agaatgttggttcctgaaaacattgacacgtacctcatccacatgatgattgagatccta
gagagcgggtcccacggcaggacccagccttcctgtgattccaacaggaagaggtgtctc
cccagccccgcagagagttgcggcagctttaagaagagcaaggagatggtcactgagacc
aaggcaccatctgagatgtcccagagaaaattacctgaatggtttgtcaaaggaaatgtg
cccttggctgctactggcagctcatcaatggccaagacaaaaaagaaaggtctttttagt
taa

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Ontology (4)   
   KEGG BRITE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (1)   
   RefSeq(pep) (5)   
DNA sequence (9)   
   RefSeq(nuc) (7)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   Pfam (8)   
All databases (35)   

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