KEGG   Rattus norvegicus (rat): 29261
Entry
29261             CDS       T01003                                 
Symbol
Tyms
Name
(RefSeq) thymidylate synthase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00240  Pyrimidine metabolism
rno00670  One carbon pool by folate
rno01100  Metabolic pathways
rno01232  Nucleotide metabolism
rno01523  Antifolate resistance
Module
rno_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    29261 (Tyms)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    29261 (Tyms)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    29261 (Tyms)
Enzymes [BR:rno01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     29261 (Tyms)
SSDB
Motif
Pfam: Thymidylat_synt
Other DBs
NCBI-GeneID: 29261
NCBI-ProteinID: NP_062052
RGD: 3921
Ensembl: ENSRNOG00000037225
UniProt: P45352 A6KFB7
Structure
Position
9:complement(120760057..120776149)
AA seq 307 aa
MLVEGSELQSGAQQPRTEAPQHGELQYLRQVEHIMRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
NT seq 924 nt   +upstreamnt  +downstreamnt
atgctggttgaaggctctgagctgcagtccggtgctcaacagccacgcacggaagccccg
cagcatggagaactccagtacctgaggcaggtggagcacattatgcgctgcggcttcaag
aaggaggaccgcacgggcactggcaccctgtcggtgttcggcatgcaggcacggtacagc
ctgagagatgaatttcctctgctcacaaccaaacgagtattctggaagggtgttttggag
gagttgttgtggtttattaagggctccacaaatgctaaagaactgtcctccaagggagtg
agaatttgggatgccaatgggtcccgagactttttggacagcttgggattctctgcccga
caggaaggagacctgggcccagtttatggattccagtggagacattttggagcagactac
aaagatatggattcagattactcgggtcaaggagtagaccagctgcaaaaagtgattgac
accatcaaaaccaaccccgatgacagaagaatcatcatgtgtgcctggaacccaaaagat
cttcccctgatggcactgcctccttgccatgccctctgtcaattttatgtggtgaatggg
gagctgtcttgccagctttaccagcggtcaggagatatgggtctgggtgtgcccttcaac
attgccagctatgctctgctgacctacatgattgcacatatcacgggcctgcagccgggt
gattttgtccatactttgggagatgcacacatttatctgaatcatattgagccactgaaa
attcagctacagcgagaaccaagacctttcccaaagctcagaatcctccgaaaagttgag
acaatcgatgatttcaaagttgaagactttcagattgaagggtataatccacatccaacg
attaaaatggaaatggctgtttag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (12)   
   RefSeq(nuc) (4)   
   GenBank (4)   
   EMBL (4)   
3D Structure (2)   
   PDB (2)   
Protein domain (1)   
   Pfam (1)   
All databases (42)   

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