KEGG   Rattus norvegicus (rat): 29554
Entry
29554             CDS       T01003                                 
Symbol
Pdha1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00010  Glycolysis / Gluconeogenesis
rno00020  Citrate cycle (TCA cycle)
rno00620  Pyruvate metabolism
rno00785  Lipoic acid metabolism
rno01100  Metabolic pathways
rno01200  Carbon metabolism
rno01210  2-Oxocarboxylic acid metabolism
rno04066  HIF-1 signaling pathway
rno04922  Glucagon signaling pathway
rno05230  Central carbon metabolism in cancer
rno05415  Diabetic cardiomyopathy
Module
rno_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    29554 (Pdha1)
   00020 Citrate cycle (TCA cycle)
    29554 (Pdha1)
   00620 Pyruvate metabolism
    29554 (Pdha1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    29554 (Pdha1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    29554 (Pdha1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    29554 (Pdha1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    29554 (Pdha1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    29554 (Pdha1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     29554 (Pdha1)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Other DBs
NCBI-GeneID: 29554
NCBI-ProteinID: NP_001004072
RGD: 3286
Ensembl: ENSRNOG00000025383
UniProt: Q4FZZ4
Position
X:38509158..38522986
AA seq 390 aa
MRKMLAAVSRVLAGAAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLPVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgaggaagatgcttgccgctgtgtcccgcgtgttggcaggcgctgcgcagaagccggca
agcagagtgctggtagcttcccgtaatttcgcaaatgatgctacatttgagattaagaaa
tgtgaccttcatcgtctagaagagggccctccagtcaccacagtgctcaccagagaggat
gggctcaagtactacaggatgatgcagaccgtgcgccggatggagctcaaggcggatcag
ctgtataagcagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcctgc
tgtgtgggcctggaggctggcataaaccccacggaccatctcatcactgcctatcgagcc
catggcttcaccttcactcggggcctgcctgtccgagcaattcttgcagaattaacagga
cgaagaggaggctgtgctaaggggaaaggcggatcaatgcacatgtacgccaagaacttc
tatggcggcaacggtatcgttggagctcaggtgcccctgggtgcaggaattgctctggcc
tgcaagtataatggcaaagatgaggtctgtttgacattatatggtgatggtgctgctaac
cagggtcagatatttgaagcttacaatatggcagcattgtggaaattaccttgtattttc
atctgtgagaataaccgctatggcatgggcacatctgttgagagagcagcagccagcacg
gattactacaaaagaggagatttcattcctggactgagggtagatggaatggatatcttg
tgtgtccgagaggcaacaaagtttgcagctgcctactgcaggtctggtaaggggcctatc
ctgatggagctacagacttaccgctaccatggacatagtatgagtgaccctggagtcagt
tatcgcactcgagaagaaatccaggaagtaagaagtaagagtgaccctattatgcttctc
aaggatagaatggtgaacagcaatcttgcaagtgttgaagaattaaaggagattgatgtg
gaagtgaggaaagaaatcgaggatgctgcccagtttgccacggctgatccggagccgcca
ttggaggagctaggctatcatatctacagcagtgacccacccttcgaagtgcgtggtgcc
aaccagtggatcaagtttaagtcagtcagttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (11)   
   KEGG MODULE (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
Protein domain (3)   
   Pfam (3)   
All databases (51)   

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