KEGG   Rattus norvegicus (rat): 296121
Entry
296121            CDS       T01003                                 
Symbol
Usp8
Name
(RefSeq) ubiquitin carboxyl-terminal hydrolase 8
  KO
K11839  ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04137  Mitophagy - animal
rno04144  Endocytosis
rno04934  Cushing syndrome
Brite
KEGG Orthology (KO) [BR:rno00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    296121 (Usp8)
   04137 Mitophagy - animal
    296121 (Usp8)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    296121 (Usp8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:rno01002]
    296121 (Usp8)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    296121 (Usp8)
   04121 Ubiquitin system [BR:rno04121]
    296121 (Usp8)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     296121 (Usp8)
Peptidases and inhibitors [BR:rno01002]
 Cysteine peptidases
  Family C19: ubiquitin-specific protease family
   296121 (Usp8)
Membrane trafficking [BR:rno04131]
 Endosome - Lysosome transport
  Others
   Others
    296121 (Usp8)
Ubiquitin system [BR:rno04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    296121 (Usp8)
SSDB
Motif
Pfam: UCH USP8_dimer WW_USP8 UCH_1 Rhodanese TFIIE-A_C Metallothio_Pro HscB_4_cys
Other DBs
NCBI-GeneID: 296121
NCBI-ProteinID: NP_001099972
RGD: 1304979
Ensembl: ENSRNOG00000010729
UniProt: D3ZN39 A6HPZ0
Position
3:134413832..134463040
AA seq 1081 aa
MPAVASVPKELYLSSSLKDLNKKTEVKPEKTSTKNYIHSAQKIFKAAEECRLDRDEERAY
VLYMKYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAIEEAERLSESLKLRYEEAEVRK
QLEEKDRREEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKIQRVNGEKSEGGAAAER
GAVTAKELYTMMMDKNTSLIIMDARKIQDYQHSCILGSLSVPEEAISPGVTANWIEAKLS
DDSKDTWKKRGSVDYVVLLDWFSSAKDLLLGTTLRSLKDALFKWESKAVLHHEPLVLEGG
YENWLLCYPQFTTNAKVTPPPRSRPEEVSVSLDFTYPSLEEPVPSKLPAQMPPPPLEANE
KAQLVTDQDGKPRPLVQSALAGPSVAPKAEASPIIQPVPATKNVPQVDRTKKPAVKLPED
HRMKSESTDQSGRVLSDRSTKPVFTSPATMLTDEEKARIHEETALLMEKNRQEKELWERQ
QKEQKEKLRREEQERKAGKTQDAEERDFTENQHKAKDGQEKRDSKQTKAEDREPPADGAQ
DATGTQRQSKSEHDASDAKVSVEGKRCPMSEVQKRPADVSSASSMSGELSAGKAQREPLT
RARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSVPPSTPPTHK
VKPQIPAERDREPSKLKRSYSSPDITQALQEEEKRRPAVTPTVNRENKPPCYPKAEISRL
SASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRS
NLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDSQELLLFLM
DGLHEDLNKADNRKRHKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCL
TCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKK
IEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKSSLKKYNLFSVS
NHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVRSSAAYILFYTSLGPRVTEAA
T
NT seq 3246 nt   +upstreamnt  +downstreamnt
atgcctgctgtagcttcagttcctaaagaactctacctcagttcttcactcaaagacctc
aataagaagacagaagttaaacctgagaaaaccagcaccaagaattatatacacagcgct
cagaagattttcaaggcagcagaagaatgcagactagatcgtgatgaggaaagggcctat
gtgctttatatgaaatatgtggcggtttataatcttatcaaaaagagacctgatttcaag
caacagcaggactattacctttcaatacttggacctgcaaacatcaaaaaggctattgaa
gaagctgaaagactctctgagagcctcaaactgagatacgaagaggctgaagttcggaaa
cagcttgaagaaaaggacagacgggaggaagaacagctgcagcaacagaaaaggcaggag
atgggaagagaggatagtggtgcggcggccaaacgctccgtggaaaatttactggattcc
aaaaccaaaatccaaagggtcaatggagagaagagcgaaggaggtgcagcagcagagaga
ggagcagtcacagcaaaggagctatatacaatgatgatggataaaaacacaagcctgatt
ataatggatgctcggaaaatacaggattatcagcattcctgtatcttgggctctctcagt
gttcctgaagaagctatcagtccaggagtcactgccaattggattgaagcaaagctttca
gatgattctaaagacacgtggaaaaaaagggggagtgtggactatgtggtcctgctggac
tggtttagttcagcgaaagatttgctgctcgggaccacgctacggagtctgaaagatgct
cttttcaagtgggaaagtaaagctgtcctgcaccatgagcccttggtgctggagggcggc
tatgagaactggctcctgtgctatccacagttcacaacaaatgctaaggttactccaccc
cctcggagcaggcctgaagaggtgtctgtctcattggattttacttatccctcactggaa
gaaccagttccttccaaacttcctgcccagatgccacctcctcctttagaagcaaatgag
aaggcacagttggtaactgatcaagatggtaaaccgagaccgttagtccagtcggctcta
gccggacccagtgtggctcccaaagctgaagcttcacccataattcagccagtgcctgct
acaaagaatgttccacaggttgatcgtacaaaaaaaccagcagttaagttgcctgaagat
catagaatgaaatctgaaagtacagatcagagtggaagagttctttctgaccgatccacc
aagccagtatttacctctccagccaccatgctaacagatgaagaaaaggctcgcattcat
gaagaaacagcccttcttatggaaaagaatagacaggagaaggaactgtgggaaaggcag
cagaaggaacagaaagagaagctgagaagggaggaacaagagcgcaaagctggaaagacc
caggatgcagaagaacgggacttcactgagaatcagcacaaagcaaaggatggacaagag
aagagagacagcaaacagaccaaggcagaagacagagagcccccagcagatggggcccag
gacgccacaggaacgcaaagacaaagtaagagtgaacacgatgcttccgatgctaaggta
tctgtggaaggtaaaaggtgtcccatgtcagaagtgcagaagaggccagcagatgtgtcg
tctgcatcctccatgtcgggagagctgagtgcaggcaaggctcagcgagaacctttgaca
agagcaagaagtgaagaaatggggagaattgtgccaggactgcctttaggctgggccaag
tttcttgatccaatcactgggacttttcgttactaccattcacccacaaacacggttcac
atgtatccgcctgagatggctccttcgtctgtgcctccttccacccctcccactcacaaa
gtcaagccccagatccctgctgagcgggacagggagccatccaaactgaagcgctcctac
tcctcaccagacatcactcaggccctgcaggaggaggagaagaggaggccagcagtgacc
ccgacagtcaaccgggagaacaagccgccgtgttaccctaaagctgagatctcgaggctt
tctgcttctcagattcggaacctcaatcccgtttttggaggatctggaccagctcttact
ggacttcgtaatttgggaaatacttgttacatgaactcaatattacagtgcctgtgcaat
gctccacatttggctgattatttcaaccgaaactgctaccaggacgatatcaacaggtca
aatttgttggggcataaaggtgaagtggcagaagaatttggtataatcatgaaggcactg
tggacaggacagtatagatacatcagtccaaaagactttaaagtcaccattggtaagatt
aatgaccagtttgcaggatccagccagcaagattcacaagagctgctgcttttcctcatg
gatggcctccacgaggatctaaataaggctgacaatcggaagaggcataaggaagagaac
aatgaccacctcgatgactttaaagcggcagaacatgcctggcagaagcacaagcagctc
aatgagtccattattgtcgcactctttcagggtcagttcaaatccacagtgcagtgcctc
acctgtcacaagaagtctcggacattcgaggctttcatgtatttgtctttgccactagca
tccacaagtaaatgtactttacaggactgccttagattattttccaaagaagaaaagctt
acagataacaacagattttactgcagccattgccgagctcggcgggattctctaaagaaa
atagaaatctggaaattgcctcctgtgctgttagtacacctgaaacgattctcctatgac
ggcaggtggaagcagaaactgcaaacgtccgtggatttcccattagaaaatcttgacctg
tcacagtatgttattggcccaaaaagcagtttgaagaaatataacttgttttctgtttca
aaccactacggcgggctcgatggaggccactacacggcctattgtaaaaacgcggcgagg
cagcgctggtttaagtttgatgaccacgaggtttcggacatctccgtgtcttctgtgagg
tcgtcagcagcttatatcctgttttacacctccctggggccacgcgtgactgaggcagcc
acataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (2)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (8)   
   Pfam (8)   
All databases (36)   

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