KEGG   Rattus norvegicus (rat): 29632
Entry
29632             CDS       T01003                                 
Symbol
Hsd3b2
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00140  Steroid hormone biosynthesis
rno01100  Metabolic pathways
rno04913  Ovarian steroidogenesis
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04934  Cushing syndrome
Module
rno_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
rno_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rno_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
rno_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    29632 (Hsd3b2)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    29632 (Hsd3b2)
   04925 Aldosterone synthesis and secretion
    29632 (Hsd3b2)
   04927 Cortisol synthesis and secretion
    29632 (Hsd3b2)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    29632 (Hsd3b2)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     29632 (Hsd3b2)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     29632 (Hsd3b2)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 Polysacc_synt_2 GDP_Man_Dehyd NAD_binding_10 RmlD_sub_bind NmrA Ufm1 KR Ldh_1_N Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 29632
NCBI-ProteinID: NP_058961
RGD: 67377
Ensembl: ENSRNOG00000019441
UniProt: Q62878 A6K3E0
Position
2:complement(188784614..188812535)
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIVQLLVQEKDLKEVRVLDKVFRPETREEFFNLGTSIKVTVLE
GDILDTQCLRRACQGISVVIHTAALIDVTGVNPRQTILDVNLKGTQNLLEACVQASVPAF
IYCSTVDVAGPNSYKKIILNGHEEEHHESTWSNPYPYSKKMAEKAVLAANGSILKNGGTL
HTCALRPMYIYGERSPFLSVMILAALKSKGILNVTGKFSIANPVYVGNVAWAHILAARGL
RDPKKSQNVQGQFYYISDDTPHQSYDDLNYTLSKEWGLHLDSSWSLPLPLLYWLAFLLEI
VSFFLHPVYNYRPSFNRHLVTLSNSKFTFSYKKAQRDLGYKPLVSWEEAKQKTSEWIGTL
VEQHRETLDTKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctgggtggagctgcctggtgactggagcaggagggtttttgggccagaggatcgtc
cagttgttggtgcaggagaaagatctgaaggaggtcagggtcctggacaaggtcttcaga
ccagaaaccagagaagaattcttcaacctagggacaagcatcaaggtgacagtgttggaa
ggagacattcttgacacccagtgcctgaggagagcgtgccagggcatctctgttgtcatc
cacactgccgccctcattgatgtcacaggtgtcaatcccaggcagaccatcctagatgtc
aatctgaaaggtacccagaatctgttggaggcctgtgtccaagctagtgtgccagccttc
atctactgcagcacagttgacgttgcagggcccaactcctacaagaagatcatcctgaat
ggccatgaggaagagcatcatgaaagcacatggtcaaatccatacccatacagcaaaaag
atggccgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggcacattg
catacttgtgccttaaggcccatgtacatttatggggagagaagtccattcctttctgtc
atgatacttgcggccctcaaaagtaagggtattctgaatgttactggcaaattctccata
gccaatccagtgtatgtaggcaatgtggcctgggcacatattctggctgccaggggcctt
cgagaccccaagaagtcacaaaatgtccaaggacagttctactacatctcagatgacacc
cctcaccaaagctatgatgatttaaattataccctgagcaaggaatggggcctccacctt
gattccagttggagccttcctctgcccctgctctactggcttgccttcctgctggaaatt
gtgagcttctttctgcatccagtgtacaactataggccatcctttaaccgccacttggtc
acactgtcaaatagcaagttcactttctcctacaagaaagctcagagagatctgggctat
aagccacttgtcagctgggaggaagccaagcagaaaacctcggagtggatcgggacacta
gtggagcagcacagggagacattggacacaaagtctcagtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (10)   
   KEGG ENZYME (2)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (12)   
   RefSeq(nuc) (8)   
   GenBank (2)   
   EMBL (2)   
Protein domain (12)   
   Pfam (12)   
All databases (83)   

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