KEGG T01003: 29680

Rattus norvegicus (rat): 29680

Entry

29680             CDS       T01003

Symbol

Cyp11a1

Name

(RefSeq) cholesterol side-chain cleavage enzyme, mitochondrial precursor

K00498

cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

Organism

rno Rattus norvegicus (rat)

Pathway

rno00140

Steroid hormone biosynthesis

rno01100

Metabolic pathways

rno04913

Ovarian steroidogenesis

rno04925

Aldosterone synthesis and secretion

rno04927

Cortisol synthesis and secretion

rno04934

Cushing syndrome

Module

rno_M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

Brite

KEGG Orthology (KO) [BR:rno00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    29680 (Cyp11a1)
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    29680 (Cyp11a1)
   04925 Aldosterone synthesis and secretion
    29680 (Cyp11a1)
   04927 Cortisol synthesis and secretion
    29680 (Cyp11a1)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    29680 (Cyp11a1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:rno00199]
    29680 (Cyp11a1)
Enzymes [BR:rno01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6  cholesterol monooxygenase (side-chain-cleaving)
     29680 (Cyp11a1)
Cytochrome P450 [BR:rno00199]
Cytochrome P450, animal type
  CYP11 family
   29680 (Cyp11a1)

SSDB

Motif

Pfam:

p450 Cytomega_US3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

RGD:

Ensembl:

UniProt:

Position

8:67318665..67330196

AA seq 526 aa
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINL
YHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYL
VPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVL
HRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFH
TSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLY
SLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQA
QGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMG
RESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENF
RIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV

NT seq 1581 nt +upstreamnt +downstreamnt
atgctggcaaaaggtctttgcctgcgctcagtgctggtcaaaagctgccaacctttcctg
agccctgtgtggcagggtccagggctggccactggaaatggagctggtatctcctctacc
aacagtcctcgatccttcaatgagatcccttcccctggtgacaatggttggataaacctg
taccacttcctgagggagaacggcacacacagaatccattatcatcacatgcagaatttc
cagaagtatggccccatttacagggagaagctgggcaacatggagtcagtttacatcctg
gaccctaaggacgcagcgacactcttctcctgcgagggtcctaacccggagcgctacctt
gtgcccccctgggtggcctatcaccagtattaccagaggcccattggggtactgtttaag
agttcagatgcctggaggaaagacagaattgtcctaaaccaagaggtgatggcccctgac
tccatcaagaacttcgtgcccctgctggaaggtgtagctcaggacttcatcaaagtctta
cacagacgcatcaagcagcaaaactctggaaagttctcaggggacatcagcgatgaccta
ttccgctttgcctttgagtccatcaccagtgttgtatttggggagcgcctggggatgttg
gaggagatcgtggaccctgagtcccagcggttcatcgacgccgtctaccagatgttccac
accagtgttcccatgctcaacatgcctccagacttatttcgactctttagaactaagacc
tggaaggaccatgcagctgcctgggatgtgattttcagtaaagctgatgaatacacccag
aacttctactgggacttaaggcagaagcgagacttcagcaagtaccctggtgtcctttat
agcctcctgggaggcaacaagctgcccttcaagaacatccaggccaacatcacagagatg
ctggcaggaggggtggacacgacctccatgactctgcaatggaacctttatgaaatggca
cacaacttgaaggtacaggagatgctgcgggctgaagttctagctgcccggcgccaggcc
cagggagacatggccaagatggtccagttggtcccactcctcaaagccagcatcaaggag
acactgagactccaccccatctctgtgaccttgcagaggtatattgtgaatgacctggtg
cttcgtaattacaagattccagccaagactttggtgcaggtggctagctatgccatgggt
cgagaatccagcttctttcccaatccaaacaagtttgacccaactcgttggttggaaaaa
agccaaaacaccacgcacttccggtacttgggctttggctggggtgttcggcagtgtctg
ggccggcggattgcagaactggaaatgaccatcttcctcatcaacgtgctggaaaacttc
agaattgaagttcaaagtatccgtgatgtggggaccaagttcaacctcatcctgatgcct
gagaagcctatcttcttcaacttccagcctctcaagcaggacctgggctcaactatgccc
agaaaaggcgacactgtatga

DBGET integrated database retrieval system