KEGG   Rattus norvegicus (rat): 303252
Entry
303252            CDS       T01003                                 
Symbol
Alox12e
Name
(RefSeq) polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type
  KO
K00458  arachidonate 12-lipoxygenase [EC:1.13.11.31]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00590  Arachidonic acid metabolism
rno01100  Metabolic pathways
rno01523  Antifolate resistance
rno04726  Serotonergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    303252 (Alox12e)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    303252 (Alox12e)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    303252 (Alox12e)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    303252 (Alox12e)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.31  arachidonate 12-lipoxygenase
     303252 (Alox12e)
SSDB
Motif
Pfam: Lipoxygenase PLAT
Other DBs
NCBI-GeneID: 303252
NCBI-ProteinID: NP_001100484
RGD: 1307642
Ensembl: ENSRNOG00000019074
UniProt: D3ZQF9
Position
10:complement(55533044..55540509)
AA seq 662 aa
MGKYKILVVTGDSLLAGSTNLVQLWLVGEHAEADLGKQLRPLRGRKTELEIDVPLHLGRL
LVVKLRKHKGLLDSDWFCKWITVQGPGIQGEAFFPCYSWVQGKETIYLPEGTALKVNDDT
KNLFRKYREQELEDRRNVYRWGSWKEGLILPIAGSTERDLPRNQRFMEDKDLDFSLSLAK
VLKDFAIKGTLDFVSRVQHLEDYQKVFPHSKTALAGRVRDSWKEDALFGYQFLNGANPML
LRRSKRLPARLVLPPGMEDLQTQLEKELKAGSLFEADFSLLDGVKPNVIIFKQQHVAAPL
VMLKLQSDGRLLPMVIQLQPPRHGCPPPLLFLPSDPPMAWLLAKIWVRSSDFQVHQLQSH
LLRGHLMAEVISVATMRSLPSLHPIYKLLAPHFRYTMEINTLARNNLVSEWGIFDLVVST
GSGGHVDILQRATACLTYRSFCPPDDLADRGLLDVKSSLYARDALRLWEIISRYVGRMVE
LFYKNDREVKEDPELQVWCREVTEIGLLGAQDRGFPLSLESRAQLCRFVTMCIFTCTGQH
ASTHLGQLDWYSWIPNGPCTMRKPPPTSKNVTEGDILDALPCLQQARMQITFTKFLGRHQ
PVMVALGQHKEEYFSDPGARAVLKQFQEELAVMDKEIEVRNASLDLPYEYLRPSMVENSV
TI
NT seq 1989 nt   +upstreamnt  +downstreamnt
atgggcaagtacaagatccttgtggtcactggagattcgcttttggcgggctccaccaac
ctggtgcagctgtggctggtgggcgagcatgcggaggcagaccttgggaagcagctgcgg
ccactgcggggaaggaagacagagctggagatcgacgtccccttgcatctagggcgcctc
ctggtggtaaagcttcgcaaacacaaaggcctattggattctgactggttctgcaagtgg
atcactgtgcagggccctgggatccaaggagaagcctttttcccctgctacagttgggtg
cagggcaaggagactatctacctacccgagggcactgccctgaaggtaaacgacgacact
aagaacctgtttaggaagtatcgagagcaggagctggaggacagaaggaatgtgtatcgg
tggggctcctggaaggagggattaatcctgcctatagcaggaagtacagagcgggacctc
cccaggaaccagagattcatggaggataaggatttagatttttccctctctctggccaaa
gtgttgaaggactttgctattaaggggactctagacttcgtaagtcgtgtacaacatctg
gaagattaccagaaagtatttccacatagcaagactgctctggccggacgggtccgtgac
tcctggaaggaagatgccctctttgggtaccagttcctcaacggtgcaaaccccatgctc
ctgaggcggtctaagcgccttccagcccggctggtcctgcctccagggatggaagattta
caaacccagctggagaaggagctcaaggctggatctctgtttgaagccgatttctccctg
ctggatggggtgaagcctaatgtcataatttttaagcagcaacacgtggcagcccctttg
gtcatgctgaagctacagtctgatgggagactcttacccatggtcattcagctccagcca
cctcgacatgggtgtcccccacccctgctcttcctgccctcggaccctcccatggcctgg
cttctggccaagatctgggtccgaagctctgatttccaagtgcaccagttacagtcacat
ctgctaaggggacatctaatggccgaggttatctctgtggccacaatgaggagcttaccc
agcctgcatcccatatacaagctccttgccccccactttcgctacaccatggagatcaac
accctggcacggaataatcttgtctcggaatggggaatttttgatctggtggtgagcaca
gggagtggaggccacgtggacattctccagagagccacagcgtgtttgacctaccgctcc
ttttgccctccggatgacttggctgaccgtgggctcttggacgtgaaatcttctctttat
gcccgggatgccctcagattatgggagatcatcagtcggtatgtgggaaggatggttgag
cttttctacaagaatgacagagaggtgaaggaagatccggagctgcaggtctggtgccga
gaggtcactgagatcggactgcttggggcccaggaccgagggttccccctgtccttagag
tcccgggctcagctgtgtcgtttcgtcaccatgtgcatcttcacgtgcactggtcagcat
gcatctacacatctgggtcagctggactggtattcctggatcccaaatggcccatgcacc
atgcggaagcccccacccacctccaagaatgtgacagagggggacattttggacgcattg
ccttgtctccagcaggcacggatgcagattacattcaccaagttcctcggcagacaccag
cctgtcatggtggccctggggcagcataaagaggaatatttctcagaccccggggcccgg
gctgtgctgaagcagttccaggaggagctggctgtcatggacaaggagattgaggtccgg
aatgcaagcctggacctgccctatgagtacctccgacccagcatggtggagaacagtgtg
accatctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (25)   

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