KEGG   Rattus norvegicus (rat): 305248
Entry
305248            CDS       T01003                                 
Symbol
Mthfd2l
Name
(RefSeq) bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
  KO
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00670  One carbon pool by folate
rno01100  Metabolic pathways
rno01240  Biosynthesis of cofactors
Module
rno_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    305248 (Mthfd2l)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     305248 (Mthfd2l)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     305248 (Mthfd2l)
SSDB
Motif
Pfam: THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 305248
NCBI-ProteinID: NP_001100681
RGD: 1310879
Ensembl: ENSRNOG00000021347
UniProt: D3ZUA0
Position
14:complement(17374139..17455508)
AA seq 338 aa
MATRARGLSLLRGRLGRGPARAPGVAERAWRGFGSSSRRHEAVIISGTEMAKQIRRELQQ
GVESWLALGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELIVKPKNVSQEELLD
ITDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPA
TASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRHT
PREQLKAHTQLAEIIIVAAGIPGLITADMVREGATVIDVGINYVQDPVTGKTKLVGDVDF
EAVKKKASFITPVPGGVGPMTVAMLLKNTLLAAKNITY
NT seq 1017 nt   +upstreamnt  +downstreamnt
atggcgacgcgggcccgtggcttgtcgctgctccggggccgcctgggccgagggcctgcg
cgagccccgggcgtagcggagcgcgcgtggcggggcttcgggagcagcagccgaagacac
gaagccgttatcatctcaggaactgaaatggccaaacagatccggagagaactacagcaa
ggtgtggaatcgtggcttgctcttgggaacaggaggcctcacctcagtatcattttagtg
ggagataacccagcaagccacacctacgtcaggaataagatcagagccgcttctgctgta
ggcatctgcagtgagctcatcgtgaagcccaagaatgtttctcaggaggaacttttggat
atcactgatcaactgaacatggacccaagagtcagtgggatattagttcaactacccctt
ccagaccacgtggatgagagaacaatatgcaatgggatcgctcccgaaaaagacgtagat
gggtttcacattatcaatatcggaagactgtgccttgaccagcattcgctgatccccgcc
acggccagcgccgtttgggaaatcatcaaaagagcaggcattgaaacatttgggaaaaac
gtggttgtggcaggacgatccaagaacgtgggcatgccgatcgccatgttgctgcacacg
gacggagagcacgagcgccccggaggcgatgcgacggtgaccatagctcacagacacacc
cccagagagcaactgaaggcccatactcagctggcagagattatcatagtggctgcaggt
attcctgggctgattactgctgacatggtcagagaaggcgcaacagtgattgacgtgggc
atcaactacgtacaagatcctgtgacaggaaagaccaagttagttggagatgtggacttt
gaagctgttaagaagaaggccagctttatcactccagtcccaggaggtgtgggacccatg
actgtggccatgcttctgaagaacacacttctggctgccaagaatatcacctactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (2)   
   Pfam (2)   
All databases (34)   

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