KEGG   Rattus norvegicus (rat): 311567
Entry
311567            CDS       T01003                                 
Symbol
Itch
Name
(RefSeq) E3 ubiquitin-protein ligase Itchy homolog
  KO
K05632  E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04120  Ubiquitin mediated proteolysis
rno04144  Endocytosis
rno04330  Notch signaling pathway
rno04668  TNF signaling pathway
rno04932  Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:rno00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    311567 (Itch)
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    311567 (Itch)
   04668 TNF signaling pathway
    311567 (Itch)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    311567 (Itch)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    311567 (Itch)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    311567 (Itch)
   04121 Ubiquitin system [BR:rno04121]
    311567 (Itch)
Enzymes [BR:rno01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     311567 (Itch)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    311567 (Itch)
Ubiquitin system [BR:rno04121]
 Ubiquitin ligases (E3)
  HECT type E3
   311567 (Itch)
SSDB
Motif
Pfam: HECT WW C2
Other DBs
NCBI-GeneID: 311567
NCBI-ProteinID: NP_001005887
RGD: 1359556
Ensembl: ENSRNOG00000059043
UniProt: Q5YB86
Position
3:164102490..164193932
AA seq 864 aa
MSDSAPQLDSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPMSKLCFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTL
QLVGDKEPTETMGDLSVCLDGLQVEAEVVTNGETSCSEGATQNDAGCRPKDETRVSTNGS
EDPEVAASGENKRANGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTNSDSD
GSSTGSLPPTNTNVNSSASEGAASGLIIPLTISGGSGPRPLNTVSQAPLPPGWEQRVDQH
GRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQ
WQLQRSQLQGAMQQFNQRFIFGNQDLFATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNH
NTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRATTYIDPRTGKSALDNG
PQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWV
IFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFR
FIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEEC
GLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFE
GFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIVWFWQFVKEI
DNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPP
YKSYEQLKEKLLFAIEETEGFGQE
NT seq 2595 nt   +upstreamnt  +downstreamnt
atgtctgacagtgcaccacagctcgattcaatgggtagcctgaccatgaaatctcaactt
cagattactgtcatctcagccaaacttaaagaaaataaaaagaattggtttggaccaagt
ccttatgtagaagtcacagtagatgggcagtcaaagaagacagaaaaatgcaacaataca
aacagccccaagtggaagcagcccctcacagttatcgttacccctatgagtaaattatgt
tttcgtgtgtggagtcaccagaccctgaaatctgatgttttattgggaactgctggatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaggaagtagttatgactttg
cagcttgtaggtgacaaagagccaacagagacaatgggagatttgtcagtttgtcttgat
gggctgcaagtagaagctgaagttgttactaatggtgaaacttcatgctcagagggtgct
acacagaatgacgctggctgcagacccaaagatgaaacaagagtgagcacaaatggatca
gaggaccctgaggttgcagcctcgggggaaaacaagagggccaatgggaacaattctcca
tccctttcaaatggtggttttaagccttctagacctcctagaccttcaagaccacctcca
cccaccccacgaagaccagcttctgtcaatggctcaccatccacgaactctgacagcgat
ggatctagcacaggctctttgccacccacaaatacaaatgtaaattcaagtgcatcggaa
ggagcagcatctgggttaataattcctctgaccatctctgggggctcaggccctaggccg
ctgaatactgtcagtcaagctcccctcccacctgggtgggagcagagagtagatcagcat
gggcgtgtttactatgtagaccatgttgaaaagcgaacaacatgggatagaccggaacct
ctacctcctggctgggaacggcgtgtggacaatatgggacgtatttattatgttgaccat
ttcacgagaaccacaacatggcagaggccgaccttggaatctgtccggaactatgagcag
tggcagctccagcgtagtcaacttcagggagcaatgcagcagtttaaccagagattcatc
tttgggaatcaagatttgtttgctacatcacaaaacaaagagtttgatccccttggtcct
ttgccccctggatgggagaagagaactgatagcaacggcagagtgtattttgtcaaccac
aacactcggattacacagtgggaagaccccagaagccaaggtcagttaaatgaaaagccc
ttaccagaaggctgggaaatgcgattcacagtggatggaattccatattttgtggaccac
aatagaagagcaactacctacatagatccacgcacaggaaagtcagccttagacaacgga
ccccagatagcctatgttcgggacttcaaggcaaaagttcagtatttccggttctggtgt
cagcaactggccatgccacagcatataaagatcacagtgacaagaaaaacattgtttgag
gattcctttcaacagatcatgagcttcagtccgcaagatctgagaagacgtttgtgggtg
attttcccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttctt
ttgtcacatgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataac
tactgcctgcagataaaccccgcttcttatatcaacccagaccacctgaaatacttccgt
tttattggcagatttattgccatggctctattccatgggaaattcatagataccggattt
tctttaccattctataaacgtatcttgaataaaccagtgggacttaaggatttagaatct
atcgatccagaattttacaattctctcatctgggttaaagaaaacaatatcgaggaatgt
ggtttggaaatgtacttctcagttgataaagaaattctgggtgaaattaagagtcatgat
ttgaaacccaatggtggcaatattctggtgacagaagaaaataaggaagagtacatcagg
atggtcgctgagtggaggttgtctcggggagttgaagagcagacacaagctttctttgag
ggctttaatgaaattcttcctcagcaatatttgcaatattttgatgcgaaggaattagag
gtccttttgtgtgggatgcaggagatcgatttgaatgactggcagagacacgccatctac
cgtcactataccaggacgagcaagcagatcgtgtggttttggcagtttgttaaagaaatt
gataacgagaagaggatgcgacttctgcagtttgttaccggaacctgccgattgccagtg
ggaggatttgctgacctcatggggagtaatggaccacagaagttctgcatcgaaaaagtt
ggcaaagaaaattggttacccagaagccatacttgttttaaccgcctggacctcccaccc
tacaagagctatgagcaactgaaggaaaagctgttatttgccattgaagaaacagaagga
tttggacaagagtaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (3)   
   Pfam (3)   
All databases (27)   

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