KEGG   Rattus norvegicus (rat): 312781
Entry
312781            CDS       T01003                                 
Symbol
Lrp6
Name
(RefSeq) low-density lipoprotein receptor-related protein 6 isoform 2 precursor
  KO
K03068  low density lipoprotein receptor-related protein 5/6
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04150  mTOR signaling pathway
rno04310  Wnt signaling pathway
rno04928  Parathyroid hormone synthesis, secretion and action
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05200  Pathways in cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    312781 (Lrp6)
   04150 mTOR signaling pathway
    312781 (Lrp6)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    312781 (Lrp6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    312781 (Lrp6)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    312781 (Lrp6)
   05226 Gastric cancer
    312781 (Lrp6)
   05224 Breast cancer
    312781 (Lrp6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    312781 (Lrp6)
   05022 Pathways of neurodegeneration - multiple diseases
    312781 (Lrp6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    312781 (Lrp6)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    312781 (Lrp6)
SSDB
Motif
Pfam: Ldl_recept_b FXa_inhibition Ldl_recept_a DUF5050 SGL cEGF EGF
Other DBs
NCBI-GeneID: 312781
NCBI-ProteinID: NP_001388749
RGD: 1304749
Ensembl: ENSRNOG00000006338
Position
4:complement(168997937..169131716)
AA seq 1613 aa
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF
GHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTE
IYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWT
DWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMS
PVKPFYQCACPTGVKLLESGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWGEIPKIERAALDGSD
RVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL
LGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCS
HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG
VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLY
WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG
SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQ
YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHC
SHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILP
IHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLS
IDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERS
PKIERAALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLE
DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ
EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGD
IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
NCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYPTEEPAPQATNTVGSVIGV
IVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMS
RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTM
EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDL
NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
NT seq 4842 nt   +upstreamnt  +downstreamnt
atgggggccgtgctgaggagcctcctggcctgcagcttctgcgtgctgctgagagcggcc
cctttgttgctttatgcaaacagacgggacttgagattggttgatgctacaaatggcaaa
gagaatgcgacgattgtagttggaggcttggaggatgcagctgcggtggactttgtgttt
ggtcatggcttgatatactggagtgacgtcagcgaagaagccattaaacgaacagaattt
aacaaaactgagagtgtacagaatgtcgttgtttctggattattgtccccggatgggctg
gcatgtgattggcttggagaaaaattgtactggacagattctgaaactaatcgtattgaa
gtttctaatttagatggatctttacgaaaagttttattttggcaagagttggatcaaccc
agagctattgccttagatccatcaagtgggttcatgtactggacagactggggagaagtg
ccaaagatagaacgtgctggaatggatggttcaagtcgctttgttataataaacactgag
atttactggccaaatggactgactctggattatgaggagcggaagctttattgggcagat
gcaaaacttaatttcatccataaatcaaacctggacggaacaaatcgacaggcagtggtt
aaaggttcccttccacatccttttgccttgacgttatttgaggacacattgtactggact
gactggaatacacactctattttggcttgcaacaagtatactggcgagggtctgcgtgaa
attcattctaacatcttctctcccatggatatacatgctttcagccaacagaggcagcca
aatgctacaaatccatgtggaattgataatggtggttgttcccatttgtgtttgatgtct
ccagtcaagcctttttatcagtgtgcttgtccaactggggtcaagcttctggagagtgga
aaaacctgcaaagatggtgccactgaactattgctgttagcccgacggacagacttgagg
cgcatctctttggatacaccagatttcaccgacattgtcctacagttagaagacatccga
catgccattgccatagactacgaccccgtggaaggctacgtctactggacggacgatgaa
gtacgggccatccgtcgctccttcattgatggatctggcagtcagtttgtggtcacggcc
cagattgcccatcctgatggtattgctgttgactgggtggcaagaaacctgtactggaca
gacactggcactgatcggatagaagtgacaaggctcaatgggaccatgaggaagatcctg
atttcagaggacttagaggagccccgggctattgtgttagatcccatggctgggtacatg
tactggacggactggggagaaatcccaaaaatcgagcgagctgctctggacggatctgac
cgagtagttcttgttaacacttcccttggttggccaaatggcttagccctggattatgat
gaaggcacaatatactggggagatgccaaaacagacaaaattgaggttatgaatactgat
ggcactgggaggcgagtgctggtggaagacaagatccctcacatatttgggtttaccttg
ctgggcgactatgtttactggactgactggcagaggcggagcatcgagagagtgcacaag
cggagtgcagagagggaggtcataatagaccagctgccagacctcatgggactgaaggcc
acaagcgttcacagagtcattggttctaacccctgtgctgaggagaatggaggatgtagc
catctttgcctctacaggcctcagggacttcgatgtgcctgtcccattggctttgagctc
attagtgacatgaagacatgcattgttcctgaggctttccttctgttctcacggagagca
gatataagacgcatctctttggaaacaaacaacaacaatgtggccattcctctcacgggt
gtcaaagaagcttctgctttggattttgatgtcacagacaacagaatttactggaccgat
atatccctgaagactattagcagagcttttatgaatggcagtgcactggaacatgtggta
gagttcggcttagattacccagaaggcatggcagtggactggcttgggaagaacttatac
tgggcagacacaggaacaaatcgcattgaggtgtcaaagttggatggacagcaccgacag
gttttggtatggaaagaccttgacagtccccgagctctggcattggatcctgctgaagga
tttatgtattggactgagtggggagggaagcctaagattgacagagcggctatggatgga
agtgaacgcactacattagttccaaatgtgggtcgagcaaatggccttaccatcgactat
gctaagaggcggctttactggacagacctggacactaacttaatagaatcttcaaatatg
ctcggactcaaccgtgaagttatagcagatgacttgcctcatccttttggcttaactcag
taccaagattacatctactggacagactggagccgacgcagcattgaacgtgccaacaaa
accagtggccaaaaccgcaccatcatccagggccatttggattatgtgatggacatccta
gtctttcactcttcccggcaggcagggtggaatgaatgtgcctccagcaacgggcactgc
tcccacctttgcttggctgtgcctgttggaggttttgtgtgtggatgccctgcccactac
tccctgaatgctgacaacaggacctgtagtgctcctaccaccttcctgctcttcagtcag
aagagcgccatcaaccgcatggtgattgatgaacaacagagtcctgacatcatccttcct
atccacagccttcggaacgtccgggccattgattatgaccctttggacaagcagctctac
tggattgactctcgacaaaacatgatacgaaaggcacaagaagatggtggccagggtttt
actgtagttgtaagctcggttccaaatcagaaccttgaaatacagccctatgatctcagc
attgatatttatagccgttacatctattggacctgtgaagctaccaatgtcattgatgtg
acgagattagatggtcgatcagttggagtggtcctaaaaggcgagcaagacagacctcga
gccattgtggtaaaccctgagaaagggtatatgtattttaccaatcttcaggaaagatct
cccaaaattgaacgggctgccttggatggaacagaacgggaggttctctttttcagtggc
ctgagtaagcccgtcgctttggctctcgacagcaagctgagcaggctcttctgggctgac
tccgacctccggcgaattgagagcagcgacctctcaggtgccaacaggatcgtgctagag
gactctaatatattgcagcctgtgggtctgaccgtgtttgagaactggctctactggatt
gataagcagcaacagatgattgaaaaaattgacatgactggtcgcgaaggcagaaccaag
gtccaggctcggattgctcagctcagtgacatccatgcagtgaaggagctgaaccttcag
gaatacagacagcacccgtgtgcccaggataatggtggctgttcacatatttgccttgta
aaaggagatggtaccacaagatgctcctgtcccatgcatttagttctgcttcaggatgag
ctgtcctgtggagagcctccaacatgttctcctcagcagtttacgtgtttcactggggac
attgactgcatccctgtggcctggcggtgtgatgggtttactgaatgtgaagaccacagt
gatgagctcaactgtcctgtgtgctcggagtctcagttccagtgtgccagcgggcagtgc
attgacggcgcccttcgatgcaatggtgacgcgaactgccaggataaatcggatgagaag
aactgtgaagtgctttgtctaattgatcagttccgctgtgccaatggtcagtgcgttgga
aaacacaagaaatgcgaccacaatgtggactgcagtgacagatctgatgaactggactgc
tatccaactgaggagccagcaccacaggccaccaacacagttggttccgttatcggagta
attgtcaccatttttgtgtctggaaccatatactttatctgccaaaggatgctgtgtcct
cgtatgaagggggatggggaaaccatgactaatgactacgtggttcacggcccagcttct
gtgccccttggttatgttcctcacccaagctctctgtctggatctcttccagggatgtct
cgaggcaaatcaatgatcagttctctcagtatcatgggggggagcagtgggcccccctac
gatcgagcacacgtcacgggagcgtcctcaagcagctcttccagtaccaaaggcacttac
ttccctgcaattttgaacccaccaccatcgcctgccacagagcgatcccattataccatg
gagtttggctattcttccaacagtccttccacacataggtcctacagctacaggccgtac
agctaccggcactttgcaccgcccactacaccctgcagcactgatgtctgtgacagtgac
tatgctcctagccggagaatgacctcagtggcaacagccaagggctacaccagtgacttg
aactatgactcagaacctgtgcccccaccacccacaccccgaagccagtacttgtcggca
gaggagaactatgaaagctgccccccttctccatacactgagaggagttactcccatcac
ctctacccaccaccaccttccccctgcacggactcctcctga

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (7)   
   Pfam (7)   
All databases (20)   

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