KEGG   Rattus norvegicus (rat): 315330
Entry
315330            CDS       T01003                                 
Symbol
Espl1
Name
(RefSeq) separin
  KO
K02365  separase [EC:3.4.22.49]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04110  Cell cycle
rno04114  Oocyte meiosis
rno05166  Human T-cell leukemia virus 1 infection
Brite
KEGG Orthology (KO) [BR:rno00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    315330 (Espl1)
   04114 Oocyte meiosis
    315330 (Espl1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    315330 (Espl1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:rno01002]
    315330 (Espl1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:rno03036]
    315330 (Espl1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.49  separase
     315330 (Espl1)
Peptidases and inhibitors [BR:rno01002]
 Cysteine peptidases
  Family C50: separase family
   315330 (Espl1)
Chromosome and associated proteins [BR:rno03036]
 Eukaryotic type
  Sister chromatid separation proteins
   Separase
    315330 (Espl1)
SSDB
Motif
Pfam: Peptidase_C50 CHAT
Other DBs
NCBI-GeneID: 315330
NCBI-ProteinID: NP_001164073
RGD: 1306266
Ensembl: ENSRNOG00000012835
UniProt: D3ZDT7
Position
7:135302460..135329570
AA seq 2109 aa
MRNFKGVKFATLLCCKRETQELLPDLKEFLSRSRTDSVSSRTDAERRQVCDTILRACTQQ
LTAKLDGPGHLRSILDLAELACDGYLLSTPQRPPLYLERILFILLRNGLTQGNPDAVLRL
AQPLHACLVQNSREAAPQDYEAVTRGTFSLLWKGAEALSERRAAFSARLKALSFLVLLED
GSLPCEVPHFASPTACRVVAAYQLFDATGQGLDAADADFVYDLLSRHVIRVLVGEGGRAS
GPLSPQRALCLLELTLEHCRRLCWNQHHHKATIAVEKTRDHLGNSNVAPSLQLCQMGVEL
LEAVEERPGAVAQLLMKAAAILNSSMDGPSPPLRALYDSCQFFLSGLERTIKRHYGVDAI
LNLFAFLGGYHSLVRHLREASEASSKQQQSLLQMHFHTLHLFTGIVYDFAQGCQVAELAQ
LVDSCRSAVVWMLEALEGLSGGELADYLGVTASYTSNLAYSFFSQKLYEEACAISEPVCQ
HLGLAKSGACPEVPPEKLHRCFRLHVESLKKWGKQAQGCKMVTLWLAALKPYGLQHMVEP
VTFWVRVKMDAAKAGDKELQLQTLRDSLSCWDPEMQSLLLREELQAYKAVRADTGQERFN
VICDLLELSPEDTAAGAWARATHLVELAQVLCYHSFAQQTNCSALDAIQEALQLLESVSP
EAQEQDRLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPSNLEEFEVNDLNYEDKLQE
DRFLYSNIAFNLAADAAQSRCLDQALTLWKEVLTKEPAPAVRCLQQTAASLQILVAIYQL
VAKPLQALETLLLLQIVSKRLQDHAKAVSSSCQLTQLLLNLGCPSYAQLYLEEAESSLKN
LDQATDTCQLLSLTCALLRSQLCWACQKVTEGVSLLLSVLRDPALQKSSKAWYLLRVQAL
QILAFYLSLSSNLLSSALREELWDQGWQTPETALIDAHKLLRSIIILLMGGDVLSVQKAA
VESPFLDYGENLVQKWQVLTEVLTCSERLVSRLGRLGNVSEAKAFCLEALKLTTKLQIPR
QCALFLVLKGELELARGDTDLCQSDLQQVLFLLESSTEFGVVTQHPDSVKRVHTQKGTHK
AQVPCSPPLPEEEPFLRGPALELVATVLKEPGPIQPSGNSSPVLKTKASPKPGFLSHLPS
CDCLLCASPALSTVCLRWVLVTAGVRLTTGHKAQGLDLLQAVLKGCPAATKRFTQNLQTS
LNHKAPPSCVPSLFDEIMAQVYTHLALECLNQTSEKSLGKVLASGLKFVATRIQYLEFWQ
ASLLLVQALAKLARFSCCTSELFASAWGWQPPLVKIPPVLEPSKIRRQKCSGQGRQRVAS
APSPLHSSSQEGLEEGPPCTPKPPGRARQAGPRVPFTIFEDIHPTKSKLKVPLAPRVHRR
AQTRLKVNFSDDSDLEDLVSAETQLVEEPKRRGTASRTRGQSRKGPSLKTDAAVAVGSTP
GHPSLSGRTRRARKVASRHCEGVGASLGPEIMRSIPEEELMDSQLEKSFEILRASDGEDS
ASGEKAAAAEPGLPIGEREVLRRDSSKAERPVLYPDTEADSDLSPWLPPFSIPAPIDLST
LDSIADSLSIAFRGISHCPPSGLYAHLCRFLALCLGHRDPYATAFLVAESVSITCRHQLL
THLHRQLSKAQKQQGSPELAEHLQRLDLKERPGGVPLARVQHLFSFRALGSGCFPQAEKD
SFQKRLALIPSGVTVCVLALATLQPGTLSNTLLLTRLEKDNPPITVKIPTAQSKFPLSAV
LKEFDAIQKDQKENSGCTEKRAWWTGRLALDQRMEELITSLEEHVLGCWRGLLLPCSTDP
GLSQEASQLQELLHECGWEYPDYTLLKVILSGARILSSQDVQALACGLCPAQPERAQVLL
SEAVGRVQSQAAPPSQHLVLVLDKDLQKLPWESMPCLRALPVTRLPSLRFLLSYSIAKEA
GASSVLSQGVDPRNTFYVLNPHSNLSSTEERFRASFSSEAGWKGVIGEVPSLEQVQAALT
EHDLYIYAGHGAGARFLDGQAVLRLNCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAG
CPLFLGNLWDVTDRDIDRYTEALLQGWLGAGPGAPLLHYVSQARQAPRLKYLIGAAPVAY
GLPVSLQTS
NT seq 6330 nt   +upstreamnt  +downstreamnt
atgaggaacttcaaaggagtcaagttcgccactctactttgctgcaagagagagacccag
gagttgctgcctgacttgaaggagttcctgtctagatctcgaactgattcagtcagcagc
agaaccgatgctgagagaagacaggtctgtgacaccatcctgagggcttgcacccagcag
ctgactgccaagcttgacggccctggtcacctgagaagtatcctggacctggcagagctg
gcctgtgacggctacttgttgtctaccccacagcgccctcccctctatctggaacgcatt
ctttttatcttacttcggaatggtttgactcagggaaacccagacgctgtgctccgcctt
gcccagcctctccatgcctgcttggtacagaactctcgagaggctgcccctcaggactat
gaggctgtgacccggggtactttttctctgctttggaagggagcagaagccctgtcagag
cggcgagctgcattctcagctaggctgaaggccttgagtttcttagtgcttttggaggat
ggcagcctcccttgtgaggtccctcactttgcttctccaacagcctgtcgggtagttgcc
gcctatcagctgtttgatgctactggacaaggtctagatgcagctgacgctgacttcgtc
tatgacttgctttctaggcatgtgatcagagtcttagtaggcgagggtggtagggcttct
ggtccgctctctcctcagagggccctctgcctcttggaactcaccttggaacattgtcgt
cgactctgctggaaccagcaccaccacaaggctaccatagcagtggagaagactcgagat
cacctaggaaatagcaatgtagctcccagcctccaactgtgccagatgggggttgagctg
ctggaagctgtggaagaaagaccaggggcagtggcccagctcctgatgaaggcagctgct
attctgaacagcagtatggatgggccatcacccccgctccgggcattgtatgacagctgc
cagttcttcctttcaggcctggagagaaccatcaagaggcactatggagttgatgccata
ttgaatctctttgcttttcttgggggataccactcccttgtccggcacctgcgagaagcc
tccgaagcgtcctctaagcagcagcagagcctgctccagatgcacttccataccctccac
ctcttcactgggattgtgtatgactttgcccaaggctgtcaggtagctgagcttgctcag
ctagtggacagttgcagatctgctgttgtctggatgttggaggccttagagggcctgtct
ggtggagagctggctgactacctgggcgtgactgcctcttacaccagcaacttggcctac
agcttctttagtcagaagctctatgaggaggcttgtgccatctcagagccagtctgtcag
cacttgggcttggctaagtcaggcgcttgtcccgaagtgcctcctgagaagctacatagg
tgcttccggctgcatgtggagagtttgaagaaatggggtaaacaggcccagggctgcaag
atggtgaccttatggctggcagctctgaaaccctacggtctccaacacatggttgagcca
gtcactttctgggttcgggtcaaaatggatgcagccaaggcaggagacaaggagctacaa
ctgcagactttgcgagacagcctaagttgctgggacccagagatgcagtctctgctactg
agggaggagctgcaggcctataaggcagtacgggctgacactgggcaggaacgcttcaac
gtcatctgcgatctgcttgagctcagccctgaggacacagcagctggagcctgggcacga
gctacccacctggtggaattggcccaagtgctgtgctaccatagctttgcccagcagaca
aactgctctgccttggatgctatccaggaggccctgcagcttctggagtccgtgagtccc
gaggcacaggagcaggaccgccttctagatgacaaagcacaggccctgctatggctctac
atctgcaccttggaggccaaaatgcaggaaggtatcgagcgggatcggagggcccaggcc
cctagtaacttggaggaatttgaagtcaatgacctgaactatgaagataaactgcaggaa
gatcgctttctatacagtaacattgccttcaatctggctgctgatgcagcgcagtccaga
tgcctggaccaggccctgactctgtggaaggaagtgctcaccaaggagccagccccagct
gtgcggtgtctccagcagacggcagcctccctgcaaatcctggtggccatctatcagttg
gtggcaaagcccttgcaggctctggagaccctcctgctccttcagattgtatctaagaga
ctacaggatcatgcaaaggcagtcagctcttcctgccagcttacccagctactcttgaac
cttggctgtcccagctatgcccagttgtatctggaagaggcagagtcaagcctgaagaat
ctggaccaagcgactgacacgtgccagctgctttccctgacctgtgctctgcttcgaagc
cagctctgctgggcttgccagaaggtgactgagggcgtttctctgttgctttctgtcctt
cgagatcctgccctccagaagtcatccaaggcttggtacttgctacgtgtccaggccctg
caaattctggctttctacctcagcctctcgtccaacctcctctcaagtgccctacgagag
gagctctgggatcaaggctggcagaccccagagacagcactgatagatgcccacaagctt
ctgagaagcatcatcatcttgctgatgggtggcgatgtgctctccgttcagaaagcagct
gtggagtcgccctttctggattacggtgagaatctggtgcagaaatggcaagttctcaca
gaggtgctgacctgctcggagaggctggtcagccgcctgggccgcctggggaacgtgagt
gaagccaaggccttttgcttggaggccctaaaacttaccaccaagctgcagatacctcgc
cagtgtgccctgttccttgtactgaagggtgagctggagctggcccggggagacactgac
ctctgtcagtcagacttgcagcaggttctgttcttgctcgagtcttccacagagtttggt
gtggtgacacagcacccagactcagtgaagagggtgcacacgcagaaagggacgcataag
gctcaagtcccctgttccccacctctaccagaagaggaacccttcctgagaggccctgcc
cttgagctggtggccactgtgctcaaggagcccggtcccatccaaccctctggaaactcc
tccccggtcctcaagaccaaggcatcacccaagcctggcttcctgtctcacttgcccagc
tgtgattgcttactgtgtgccagtcctgccctctccaccgtctgtctgcgctgggtgttg
gtcactgcaggagtgaggctcaccacaggtcataaagctcagggtctggatctgctgcaa
gctgtgctgaagggttgccctgcagccaccaagcgcttcacacagaatcttcaaacttct
ctgaatcacaaagcacccccctcttgtgttccaagcctctttgatgagatcatggctcaa
gtgtacacacacttggcattagagtgcctgaatcagacatctgaaaagagcctgggaaag
gtcctggcgtcaggactgaagtttgtggcaacacggatacaatacttagagttctggcaa
gccagcctgctcttggttcaggcccttgcaaagctggcccgcttcagctgctgtactagc
gaactctttgcaagcgcctggggctggcagccaccattagtaaaaatcccgccagtcctt
gagccttctaagattcggagacaaaaatgctctggacaggggcgccagcgggtagcctct
gccccctcacccctccatagcagctctcaggaaggtctggaagaagggccaccttgtaca
cctaagcccccaggccgtgctaggcaagccggccctcgtgtccctttcaccatatttgaa
gacatccaccccacaaagagcaagcttaaggttcccttggctcccagggtccacaggcgg
gcccagactcgactcaaggtgaacttcagcgatgacagcgacctggaagaccttgtctca
gctgaaacacaacttgtggaggaacctaagaggcgagggactgcttcccgcacccggggt
cagagtaggaagggccctagcttaaagacagatgcagcggttgccgtaggtagtacccct
ggacatcccagtctcagtgggaggactcggagggccaggaaggtggcttcaagacattgt
gaaggtgtcggggccagcctgggacccgaaatcatgagaagcatccctgaagaggagctg
atggacagccagctagaaaagagctttgagattctcagggcttctgatggggaagactca
gcctcaggcgagaaggcagcagctgcagagcctggtctacccataggagagcgtgaggtg
ttgagacgggactccagcaaggcagagcgacctgtcttgtaccctgatacagaggccgat
agtgaccttagtccttggctcccacccttctcaattcctgcacccattgatctttctacc
ctggattccatcgctgactcattgagcattgcttttcgtggtattagtcactgccctcca
agtgggctctacgctcacctctgccgctttttggccttgtgtctgggccaccgggatccc
tatgccactgcgttccttgtagcagagtctgtctccatcacctgccgtcaccagctactc
acccatttgcaccgacagctcagcaaggcccagaagcagcaaggctcacctgaactagca
gagcatctacagaggctggacttgaaggagaggcccggaggtgtcccactggcccgcgtg
cagcacctcttttccttcagggctttgggatctggctgcttcccccaggcagagaaggac
agtttccagaagcgcctggctctcatccccagtggggtgactgtctgcgtgttggccctg
gccaccctccagcctggaaccttgagcaacactctcttactgacccgcctggaaaaggac
aaccccccaattactgtgaagatccccactgcccaaagtaagttcccactaagtgcggtg
ctgaaagagttcgatgccatccagaaggaccagaaagagaacagcggctgtactgagaaa
cgagcgtggtggacgggccggctagcactagaccaaaggatggaggaactcattacctcc
ctagaggagcatgtgctgggctgctggagggggctgctgctgccgtgtagcaccgaccct
ggcctttcccaggaggcctcccaactacaagagttgctgcacgaatgtggctgggaatat
cctgattacactctcctaaaagtcattcttagtggggccagaatcctctccagccaggat
gttcaggccttggcatgtgggctgtgcccagcccaacctgagcgagcccaagtgctcctg
agcgaggcagtaggacgggtacagagccaggcagcccctccgagtcaacatcttgtactg
gtgttagacaaggacctgcagaagctgccgtgggaaagcatgccatgcctccgagcactg
ccggtcacccggctgccctccctccgcttcctgctcagctactcaatcgctaaggaggct
ggggcctcatcagtgctgagccaaggtgttgatccacgcaataccttctatgtgctaaac
cctcacagtaacctgtcgagcacggaggagagatttcgagccagttttagcagtgaagcc
ggatggaaaggcgtgattggggaagtgcccagccttgagcaggtgcaggctgccctgaca
gagcatgatttatatatctatgcaggacatggagctggtgcccgcttccttgatgggcag
gctgtcctgcggctgaactgccgggcagtggccctactgttcggctgcagcagtgcagcc
ctcgcagtgcatggaaacctggagggagctggtattgtgctcaagtacatcatggctggc
tgccccttgttcctaggtaatctctgggatgtgactgaccgtgatattgaccgttacaca
gaggctttgctgcagggctggctgggagcaggcccaggggctccccttctccactatgtc
agccaagcccgccaggccccacgactcaagtatcttattggtgctgcacctgtagcctac
ggcctacctgtctctctacaaacatcctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (2)   
   Pfam (2)   
All databases (24)   

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