KEGG T01003: 360348

Rattus norvegicus (rat): 360348

Entry

360348            CDS       T01003

Symbol

Hsd3b1

Name

(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

K00070

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

Organism

rno Rattus norvegicus (rat)

Pathway

rno00140

Steroid hormone biosynthesis

rno01100

Metabolic pathways

rno04913

Ovarian steroidogenesis

rno04925

Aldosterone synthesis and secretion

rno04927

Cortisol synthesis and secretion

rno04934

Cushing syndrome

Module

rno_M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

rno_M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

rno_M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

rno_M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Brite

KEGG Orthology (KO) [BR:rno00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    360348 (Hsd3b1)
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    360348 (Hsd3b1)
   04925 Aldosterone synthesis and secretion
    360348 (Hsd3b1)
   04927 Cortisol synthesis and secretion
    360348 (Hsd3b1)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    360348 (Hsd3b1)
Enzymes [BR:rno01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     360348 (Hsd3b1)
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     360348 (Hsd3b1)

SSDB

Motif

Pfam:

3Beta_HSD Epimerase NAD_binding_4 Polysacc_synt_2 GDP_Man_Dehyd NAD_binding_10 RmlD_sub_bind NmrA KR Ldh_1_N Sacchrp_dh_NADP DapB_N Semialdhyde_dh

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

RGD:

Ensembl:

UniProt:

Position

2:complement(188858574..188864694)

AA seq 373 aa
MPGWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETKEEFSKLQTKAKVTMLE
GDILDAQYLRRACQGISVVIHTAAVIDVSHVLPRQTILDVNLKGTQNILEACVEASVPAF
IYCSTVDVAGPNSYKKIILNGHEEEHHESTWSDAYPYSKRMAEKAVLAANGSILKNGGTL
HTCALRPMYIYGERSPFLSVMILAALKNKGILNVTGKFSIANPVYVGNVAWAHILAARGL
RDPKKSQNVQGQFYYISDDTPHQSYDDLNCTLSKEWGLRLDSSWSLPLPLLYWLAFLLET
VSFLLRPFYNYRPPFNCHLVTLSNSKFTFSYKKAQRDLGYVPLVSWEEAKQKTSEWIGTL
VEQHRETLDTKSQ

NT seq 1122 nt +upstreamnt +downstreamnt
atgcctggatggagctgcctggtgacaggagcaggagggtttgtgggccagaggatcatc
cggatgttggtgcaggagaaagaactgcaggaggtcagggctctggacaaagtcttcaga
ccagaaaccaaggaggaattctctaagctgcagacaaaggccaaggtgacaatgttagaa
ggagatattctggatgcccagtacctgaggagagcgtgccagggcatctctgttgtcatc
cacaccgctgctgtcattgatgtctcacatgtcctacccaggcagaccatcctagatgtc
aatctgaaaggtacccagaacatattggaggcctgcgtcgaagccagtgtgccagccttc
atctactgcagcacagttgacgttgcagggcccaactcctacaagaagatcatcctgaat
ggccatgaggaagagcatcatgaaagcacatggtcagatgcatacccatacagcaaaagg
atggccgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggcacactg
catacttgtgccttaaggcccatgtacatttatggggagagaagtccattcctttctgtc
atgatacttgcggccctcaaaaataagggtattctgaatgttactggcaaattctccata
gccaatccagtgtatgtaggcaatgtggcctgggcacatattctggctgccaggggcctt
cgagaccccaagaagtcacaaaatgtccaaggacagttctactacatctcagatgacacc
cctcaccaaagctatgatgatttaaattgcaccctgagcaaggaatggggcctccgcctt
gattccagctggagccttcctctgcccctgctctactggcttgccttcctgctggaaact
gtgagcttcctgctgcgtccattttacaactataggccaccctttaactgccacttggtc
acactgtcaaatagcaagttcactttctcctacaagaaagctcagagagatctgggctat
gtgccacttgtcagctgggaggaagccaagcagaaaacctcggagtggatcgggacacta
gtggagcagcacagggagacactggacacaaagtctcagtga

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