KEGG   Rattus norvegicus (rat): 360827
Entry
360827            CDS       T01003                                 
Symbol
Ulk1
Name
(RefSeq) serine/threonine-protein kinase ULK1
  KO
K21357  serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04137  Mitophagy - animal
rno04140  Autophagy - animal
rno04150  mTOR signaling pathway
rno04152  AMPK signaling pathway
rno04211  Longevity regulating pathway
rno05010  Alzheimer disease
rno05014  Amyotrophic lateral sclerosis
rno05016  Huntington disease
rno05017  Spinocerebellar ataxia
rno05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    360827 (Ulk1)
   04150 mTOR signaling pathway
    360827 (Ulk1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    360827 (Ulk1)
   04137 Mitophagy - animal
    360827 (Ulk1)
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    360827 (Ulk1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    360827 (Ulk1)
   05014 Amyotrophic lateral sclerosis
    360827 (Ulk1)
   05016 Huntington disease
    360827 (Ulk1)
   05017 Spinocerebellar ataxia
    360827 (Ulk1)
   05022 Pathways of neurodegeneration - multiple diseases
    360827 (Ulk1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    360827 (Ulk1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    360827 (Ulk1)
   03029 Mitochondrial biogenesis [BR:rno03029]
    360827 (Ulk1)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     360827 (Ulk1)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: Other
  ULK family [OT]
   360827 (Ulk1)
Membrane trafficking [BR:rno04131]
 Autophagy
  Autophagosome formation proteins
   ULK complex
    360827 (Ulk1)
Mitochondrial biogenesis [BR:rno03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    360827 (Ulk1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ATG1-like_MIT2 ATG1-like_MIT1 Kdo ABC1 RIO1 Pkinase_fungal Kinase-like
Other DBs
NCBI-GeneID: 360827
NCBI-ProteinID: NP_001101811
RGD: 1589743
Ensembl: ENSRNOG00000037505
UniProt: A6J290
Position
12:51511492..51537746
AA seq 1051 aa
MEPGRGGVETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQ
QIAGAMQLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
PAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSPPVPVPSYPSSGS
GSSSSSSSASHLASPPSLGEMPQLQKTLTSPADAAGFLQGSRDSGGSSKDSCDTDDFVMV
PAQFPGDLVPEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRPGP
FSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASPSP
PSHTDGAMLARKLSLGGGRPYTPSPQVGTIPERPSWSRVPSPQGADVRAGRSPRPGSSVP
EHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQSCRP
LRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKAPSSQSLLTLLARQGVVMTPPRNRTL
PDLSEAGPFQGQQLGSGLRPAEDTRGPFGRSFSTSRLTDLLLKAAFGTQASDSGSTDSLQ
EKPMEIAPSAGFGGTLHPGARAGGASSPAPVVFTVGSPPSGTTPPQSTRTRMFSVGSSSS
LGSTGSSSARHLVPGACAEAPELSAPGYCCSLADPLAANLEGAVTFEAPDLPEETLMEQE
HTETLHSLRFTLAFAQQVLEIAALKGSASEAAGGPEYQLQESVVADQISQLSREWGFAEQ
LVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQR
FFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHRESCVPRYHKALLLLEGLQH
TLTDQADIENIAKCKLCIERRLSALLSGVYA
NT seq 3156 nt   +upstreamnt  +downstreamnt
atggagccgggccgcggcggcgtcgagaccgtgggcaagttcgagttctctcgcaaagac
ctgattggacacggcgccttcgcggtggtcttcaagggtcgacaccgcgagaagcacgac
ctggaggtggccgtcaaatgcattaacaagaagaaccttgccaagtcccagacactgcta
ggaaaggaaatcaaaatcctgaaggaactaaagcacgaaaacattgtggcgttgtatgac
ttccaggagatggccaattctgtctacctggtcatggagtattgtaatggtggagacctg
gctgactacctgcacactatgcgcacactgagtgaagacactgtcaggctgttcctacaa
cagattgcaggtgccatgcagctgctacacagcaagggcatcattcaccgtgatttgaag
ccccagaacatcctgctgtccaatcccgggggtcgacgtgccaaccccagcaacatccga
gtcaagattgctgactttggatttgcccggtacctccagagcaacatgatggcggccacg
ctctgtggctctcctatgtacatggcccctgaggttatcatgtcccagcactacgatggg
aaggctgacctgtggagcattggcaccattgtctaccagtgtctgacagggaaggcccct
tttcaggccagcagccctcaggatttgcgcctgttttatgagaagaacaagacactagtt
cctgccatcccacgggagacatcagctcccctgcggcagttgcttctggctctattgcag
cgtaaccacaaggaccgcatggactttgatgaatttttccaccaccctttcttagatgcc
agcacccccatcaagaaatccccacctgtgcctgtgccctcatatccaagctcagggtcc
ggcagcagctccagcagcagctctgcctcccacctggcatctcccccgtccctgggggag
atgccgcaactgcagaagacccttacctccccagctgatgctgctggctttctgcagggg
tcccgggactctggtggcagtagcaaagactcctgtgacacagatgactttgtcatggtc
ccagcccagtttccaggtgatctagtccctgaggcagccagtgccaagcccccacctgac
agtctgctgtgtagtgggagctcactggtggcctctgctggcctagagagccatggccgt
accccatctccctctccgacctgcagcagctctcccagcccctctggccggcctggcccc
ttctccagcaacaggtacggtgcctcggtccccattcctgtccccactcaggtgcacaac
taccagcgcatcgagcagaacctgcagtcacctactcaacagcagacagcccggtcttct
gccatccgaaggtcaggtagcaccagccccctgggctttggtcgggccagcccatcacct
ccctcgcacactgatggagccatgctggccaggaagctgtcactaggaggtggccgtccc
tacacaccctctccccaagtgggaaccatcccagagcggcccagctggagcagagtaccc
tccccacaaggagctgatgtgcgggctggcaggtcaccacgaccaggctcctctgtgcct
gagcactctccacgaaccaccgggctgggctgccgcctgcacagtgcccccaacctttcg
gacttccatgtcgttcgtcccaagctgcctaagcctccaacagacccactgggagctacc
ttcagcccaccccagaccagcgcaccccagccatgcccagggctacagtcttgccggcca
ctgcgtggctcacctaagctgcctgacttcctacagcggagtcccctaccccccatccta
ggctctcctactaaggctggaccctcgtttgacttccccaaagcccccagctctcagagt
ttgctgaccctgttggctaggcagggtgtagtaatgacaccacctcggaaccgtacactg
cctgacctctcagaggcgggtcctttccagggccagcagctgggctctggcctacggccc
gccgaagacacaaggggcccctttggccggtccttcagcaccagccgccttacggacctg
ctgcttaaggctgcatttgggacacaggcctctgactcaggcagcactgacagcctacag
gagaaacctatggagattgctccctctgctggttttggagggactctgcatccaggagct
cgtgctggaggggcaagcagcccagcacctgtggtatttactgtgggctccccacccagt
ggtaccaccccaccccagagtacccgcaccagaatgttctcagtgggctcttccagctcc
ctgggctcgactggctcctcctctgcccgccacttagtgcctggggcttgtgcagaggcc
ccggagctttctgccccaggctactgctgtagccttgctgacccccttgctgccaacttg
gagggggctgtgaccttcgaggctcctgacctcccagaggagaccctcatggagcaagag
cacacggaaaccctacacagcctgcgcttcacactagcgtttgcacagcaagttctggag
attgcagccctgaagggcagtgccagtgaggcagccgggggccctgagtaccagcttcag
gaaagtgtggtggctgaccagatcagtcagttgagccgagagtggggctttgcagagcaa
ctggttctgtacttgaaggtggctgagctgctctcttcaggcttacagactgccattgac
cagattcgagctggcaagctctgcctttcgtctactgtgaagcaggtggtacgcagacta
aatgagctgtataaggccagcgtggtatcctgccagggcctcagtctgcggcttcagcgc
ttctttctggacaagcaacggctgctggatgggatccatggtgtcactgcagagcggctt
atcctcagccatgctgtgcagatggtacaatcagctgcactcgatgagatgttccagcac
cgagagagctgtgtacctcgatatcacaaagccctgctgttgttggaggggctgcagcac
actctcacggaccaggcagacattgagaacattgccaaatgcaagctgtgcattgagagg
agactctcggccctgctgagtggcgtctatgcctga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (9)   
   Pfam (9)   
All databases (39)   

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