KEGG   Rattus norvegicus (rat): 361100
Entry
361100            CDS       T01003                                 
Symbol
Top2b
Name
(RefSeq) DNA topoisomerase 2-beta
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:rno00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    361100 (Top2b)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:rno03032]
    361100 (Top2b)
   03036 Chromosome and associated proteins [BR:rno03036]
    361100 (Top2b)
Enzymes [BR:rno01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     361100 (Top2b)
DNA replication proteins [BR:rno03032]
 Eukaryotic type
  DNA Topoisomerases
   361100 (Top2b)
Chromosome and associated proteins [BR:rno03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    361100 (Top2b)
  Centrosome formation proteins
   Centriole proteins
    361100 (Top2b)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT Toprim HATPase_c
Other DBs
NCBI-GeneID: 361100
NCBI-ProteinID: NP_001094328
RGD: 1586156
Ensembl: ENSRNOG00000048795
UniProt: Q14TE9
Position
15:complement(11482089..11542464)
AA seq 1614 aa
MAKSSLAGVDGALTWVNNAAKKEELETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYI
GSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDP
ESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCN
IFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLAKFKMEKL
DKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHE
LANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSV
KPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESI
LNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVS
GLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTL
RYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYS
IPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITL
AFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDN
ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNL
AQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYD
DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPN
YKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTP
ALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKK
YETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKK
DLIQMLVQRGYESDPVKAWKEAQEKAAEEEDAQNPHDDSSSDSGTPSGPDFNYILNMSLW
SLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMS
GKAVKGKVGKAKVKKLQLEETMPSPYGRRIVPEITAMKADASRKLLKKKKGDPDTTVVKV
EFDEEFSGTPAEGTGEETLTPSAPVNKGPKPKREKKEPGTRVRKTPASTGKPNTKKVKKR
NPWSDDESKSESDLEEAEPVVIPRDSLLRRAAAERPKYTFDFSEEEEDDADDDDDNNDLE
ELKVKASPITNDGEDEFVPSDGIDKDEYAFSPGKSKATPEKSSHDKKSQDFGNLFSFPSY
SQKSEDDSAKFDSNEEDTTSVFAPSFGLKQTDKVPSQTVAAKKGKAPSDAAAPKAKRAPR
QRKVVEPANSDSDSELGNIPKKTAAPKGKGRGAKKRKASGSENEGDYNPGRKPSKTASKK
PKKTSFDQDSDVDIFPSDFTSEPPALPRTGRARKEVKYFAESDEEEDVDFAMFN
NT seq 4845 nt   +upstreamnt  +downstreamnt
atggccaagtccagcctcgcgggcgttgacggggcgctgacctgggtgaacaatgctgca
aaaaaggaagagttggagacagcgaacaaaaatgattcttccaagaagttgtctgttgag
agagtgtaccagaagaagacccaactggagcatattctccttcgtcctgatacatacatt
ggatcagtggaaccactgacacagttaatgtgggtgtatgacgaagatgtaggcatgaac
tgcagagaggttacctttgttccgggcttatacaagatctttgatgaaattttggtcaat
gctgctgacaacaagcagagggataagaacatgacctgtattaaggtttctattgatcct
gaatctaatattataagcatttggaataatggaaaaggcattccagtagtagaacacaaa
gtagagaaagtttatgttcctgctttaatttttggacagcttttaacatcgagtaattat
gatgatgatgagaaaaaagttacaggaggccgtaatggttatggtgcaaaactttgtaat
atttttagtacaaagtttacagtagaaacggcttgcaaagaatacaaacatagttttaag
cagacatggatgaataatatgatgaagacttctgaagccaaaatcaaacattttgatggg
gaagattatacatgcataacattccagccagatctagccaagtttaagatggaaaaactt
gacaaggacattgtggccctcatgaccagaagggcatacgatttagctggttcctgcaaa
ggcgtcaaggtcatgttcaatggcaagaagttgcctgtaaatggatttcgcagctatgta
gacctttatgtgaaagacaaattggatgaaactggggtcgctctcaaagttattcatgaa
cttgcaaatgaaagatgggatgtttgtctaaccttgagtgaaaaaggtttccagcagatc
agctttgtgaatagtattgcaactacaaaaggtggacggcacgtggattacgtagtagat
caagttgttggtaaactgattgaagtagttaagaaaaagaacaaagctggtgtatcagtg
aagccatttcaagttaaaaaccacatatgggtttttattaattgtcttattgaaaatcca
acctttgattctcaaactaaggaaaacatgactctgcagcccaagagctttgggtctaaa
tgccagctgtcagaaaagttctttaaagcggcctctaattgtggcattgtagaaagcata
ttgaactgggtgaaatttaaggctcagactcagctgaataagaagtgctcctcagtaaag
tacagcaaaatcaaaggcattcccaaactggatgatgccaatgatgctggtggcaaacat
tccctggagtgtacattaatattaacagagggggactctgccaaatctctagctgtctct
ggattaggtgtgattgggagagacagatatggagtcttccctctcaggggtaaaattctc
aatgtacgagaagcgtctcataaacagattatggaaaatgcagaaataaacaatattatt
aaaatagttggtttgcaatacaagaaaagttatgatgatgcagaatctctgaaaacttta
cgttatgggaagattatgattatgactgatcaggatcaagatggttctcacattaaaggc
ctgctaatcaattttattcatcacaattggccatcacttttgaagcatggctttcttgaa
gaattcattactcccattgtaaaggcgagcaaaaataagcaggaactttccttttatagt
attcctgaatttgatgagtggaaaaaacatatagaaaaccagaaagcctggaaaataaag
tactacaaaggattgggtaccagtacagctaaggaagccaaggaatattttgctgatatg
gaaaggcatcgcattttgtttagatatgctggccctgaggatgatgctgccattaccttg
gcatttagtaagaagaagattgatgacagaaaagaatggttaaccaactttatggaggat
cggagacagcggaggttacatggcctaccagagcaatttttatatggtacagcaactaag
catttgacatacaatgatttcatcaacaaggaattgattctcttctcaaactcggacaat
gagagatctataccctctcttgtggatggcttcaagccaggtcaacgaaaagttttgttt
acctgtttcaagaggaatgataaacgtgaagttaaagtcgcacagctggctggatctgtt
gctgaaatgtctgcttatcatcatggagaacaagcgttgatgatgactattgtgaatttg
gctcagaattttgtgggcagcaacaacattaacttgcttcagcccattggtcagtttgga
actcggcttcacggtggcaaagatgctgcaagcccccgttatatcttcacaatgttaagc
tctctggcaagactactttttccagctgtggatgataacttgcttaagttcctttatgat
gataatcagcgtgtagagccggagtggtatatccccataatccccatggttttgattaat
ggtgctgagggtattgggactggatgggcttgtaaattgcccaactatgatgccagagaa
attgtgaacaatgtcaggcggatgctagaaggtttggatcctcaccccatgcttccaaac
tataagaacttcaaaggcaccatccaggagcttggtcagaaccagtatgctgttagtggt
gagatatttgtggtggacagaaacacagtagagattacagaacttccagttagaacctgg
acacaggtatacaaggagcaggtcctagaacctatgcttaatggaacagataaaacacca
gcactgatttctgattacaaagaatatcacactgatacaactgtgaaatttgtggtgaag
atgacagaagagaagctcgcccaagcggaagctgccggcctgcataaagtttttaaactc
caaaccactcttacttgcaattccatggtactctttgatcatatgggatgtctgaagaag
tatgaaactgtgcaagacattttgaaagaattctttgatttacggttaagttattatggt
ttacggaaggagtggcttgtaggaatgttgggagcagaatccacaaagcttaacaatcaa
gcccgtttcattttagagaagatacaagggaaaatcacgatagagaataggtcaaagaaa
gatttgattcaaatgttagtccagagaggttatgaatctgacccagtgaaagcctggaaa
gaagcacaagaaaaggctgcggaagaggaagatgcacaaaacccacatgatgacagttcc
tctgactcaggaactccttcaggccctgattttaattatattttaaatatgtctctatgg
tctcttactaaagaaaaagttgaagaactcattaaacagagagatacaaaaggacgagag
gttaatgatctcaaaaggaaatctccctcagatctttggaaagaagatttagcagcattt
gttgaagaattggataaagtggaagcacaagaacgagaagacattctggcagggatgtct
gggaaagcagtgaaaggcaaagtcggcaaagctaaagtaaagaagctccagctggaggag
acgatgccctcgccttacgggagaagaatcgttcctgagattactgccatgaaggcagac
gccagcagaaaactgctgaagaagaagaagggtgatcctgatactacagttgtgaaagta
gaatttgatgaagaatttagtggaacaccagcagaaggtacaggagaagagacattgaca
ccatctgctcctgtaaataaaggccccaaacccaaaagggagaaaaaggagcctggtacc
agggttagaaaaacacctgcatcaactggcaaacctaatacaaagaaagtgaagaagcgg
aatccttggtcagatgatgagtccaaatcagagagtgacttggaagaagcagagcctgtg
gttatcccaagagattctttgcttaggagagcagctgctgaaagacctaagtacactttt
gatttctcagaagaggaggaggatgatgctgatgatgatgacgacaataatgatttagaa
gaattgaaagttaaagcatctcccataacaaatgatggggaggatgaatttgttccttca
gatggcatagataaagatgagtatgccttttctccaggcaaatccaaagctacaccagaa
aaatcttcacatgacaaaaaaagtcaggattttggaaatcttttttcatttccttcatat
tctcagaagtcagaagatgattcagctaaatttgacagtaatgaagaagacaccacatct
gtttttgcaccatcatttggtctgaagcaaacagataaagttccaagtcaaacagtcgct
gctaaaaagggtaaagcaccttcagatgcagcagcccctaaggccaagagagcccctaga
cagaggaaggtagtagagcctgcaaactccgactcggattctgaactcggcaacattcca
aagaagacggccgcaccgaaaggtaaaggccgaggggcaaagaaaaggaaagcatcaggc
tcagaaaatgaaggtgattataaccctggcaggaaaccatctaaaacagccagcaagaaa
ccgaagaaaacgtcttttgatcaggattcagatgtagacatcttcccttcagacttcact
tctgaaccacctgctctcccacggactggtcgggctaggaaagaagtaaaatattttgca
gagtctgatgaagaagaagacgttgattttgcaatgtttaattaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (6)   
   Pfam (6)   
All databases (26)   

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