KEGG   Rattus norvegicus (rat): 362831
Entry
362831            CDS       T01003                                 
Symbol
Dot1l
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific
  KO
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00310  Lysine degradation
rno01100  Metabolic pathways
rno05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    362831 (Dot1l)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    362831 (Dot1l)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:rno03036]
    362831 (Dot1l)
Enzymes [BR:rno01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     362831 (Dot1l)
Chromosome and associated proteins [BR:rno03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     362831 (Dot1l)
   HMT complexes
    Dot1-containing complex
     362831 (Dot1l)
SSDB
Motif
Pfam: DOT1
Other DBs
NCBI-GeneID: 362831
NCBI-ProteinID: NP_001102203
RGD: 1306644
Ensembl: ENSRNOG00000032546
UniProt: A6K8G9
Position
7:complement(9569439..9607095)
AA seq 1540 aa
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVP
ESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLNKKGRKMAGRKRGRPKKMSAAS
ADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPDPLLVAPTPP
ALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQKEE
IRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRA
RCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSC
VPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSMNGHAASYEL
CGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLR
RHLSQDHTGASKAATSEPHPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTS
ERGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPS
PVPQPRDSSSTLEKQIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLAS
GMESAVFEESSGPSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQG
SLPDTGKGELPADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSH
GQDSRKRSRRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLE
ITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSAR
IERKIATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDS
PLQASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFS
GGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGG
LKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGL
LGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLF
STVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN
NT seq 4623 nt   +upstreamnt  +downstreamnt
atgggcgagaagctggagctgaggctcaagtcgcctgtgggcgcggagcccgccgtctac
ccgtggccgctgccggtctacgacaagcaccatgatgctgctcatgagattatcgagact
atccgatgggtctgcgaggaaatcccagatctcaagctggccatggagaactatgtcctg
atcgactacgacaccaaaagttttgaaagcatgcagaggctgtgtgacaaatataaccgg
gccattgacagcatccaccagctgtggaagggcactacacagcccatgaagctcaatact
cggccgtccaatgggctcctgcggcacatcctgcagcaggtgtacaaccactctgtgacc
gacccagagaagctcaacaactacgagcccttctcccccgaggtgtacggggagacctcc
tttgacctggtggcccagatgatcgatgagatcaagatgaccgaggatgacctgtttgta
gacctgggcagtggtgtggggcaggttgtccttcaggttgcggcggccaccaactgcaaa
catcactacggagtggagaaagcggacatcccagccaagtacgcggagaccatggatcga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagcga
ggtgacttcctctcagaggagtggagggaacggatcgccaacacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggaacgattcgcaaacatg
aaggaaggcggcagaatcgtatcctcaaagccctttgcccctctgaacttcaggatcaac
agcaggaacttgagtgacattggcaccatcatgcgtgtggtggagctgtcgcccctgaag
ggctctgtgtcatggactggcaagcctgtctcctactacctgcacaccattgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggagcaggaggca
gctaggcgcaggcagcagcgagagaacaagagcaacgcgaccacacccaccaaagtccct
gagagcaaggcagctgccaccgaggcccctgcggattctggtgctgaggaagaaaaatca
ggtgtggccaccgtcaaaaagcaatctccctccaaagcccggaagaagaaactgaacaag
aaagggagaaaaatggctggccggaagcgtgggcgacccaagaaaatgagtgctgccagt
gccgatcgcaagtccaagaagagccaaagcacactggatctcctgcactctccgccccca
gccccaccctcagcctcaccccaggatgcatacagggccccccacagcccgttctaccag
ctacctccgagcacgccgctgcactcgcccgacccactgctagtggctcccaccccaccc
gcgctgcagaagctgttagagtccttcaagatccagtacctgcagttcctggcctacacg
aagaccccgcagtacaaggccaacctgcagcagcttctggaccaggagaaggagaagaac
acacaactgctgggtacagcccagcagctcttcagccattgccaggcacaaaaggaagag
atccgcaggctgttccagcagaagctggatgagttgggcgtgaaggcactgacctacaat
gacctgattcaggcccagaaggaaatctctgcccacaaccagcagctgcgggagcagtcg
gaacagctggagaaggacaacagcgagcttcggagccagagcctgcggctgctcagggcc
cggtgcgaagagctgaggcttgactggtccaccttgtccctggagaacctgcggaaagag
aagcaggccctgcggagccagatctcagagaagcagcggcactgcctagagctgcagatc
agcatcgtggagctggagaagacccagcgccagcaggagctcctgcagttgaagtcctgt
gtgccaccagatgacgctctgtccctgcacctgcgtggcaagggtgccctgggccgcgag
ctggagtctgacgctgggcgcttgcgccttgagctggactgtgccaagctctccctccca
cacctcagcagcatgagccctgagctgtccatgaatggccatgccgccagctatgagctc
tgcggtgcagctagtcggccctcgtccaagcagaacaccccccagtatctggcctccccc
ttggaccaggaggtcgtgccctgcacccctagccacagtggccggcctcggctggagaag
ctgtctggcctggctttgcctgactacacccggttgtcaccggccaagattgtgttgagg
cggcacctgagccaggaccacaccggggccagcaaagcagctactagtgagccacaccct
cggccagagcatgccaaggagaacagccttccctaccagagccctggcttgtcgaacagc
atgaagctcagcccccaggatccaccgctggcctccccggcaacctcacccctcacttcc
gagaggggtagtgagaagggtgtaaaggagcgtgcctacagcagccatggggagaccatc
accagcctgcctgtcagcattccactcagcacagtacagcccaacaagctgcctgtcagc
atcccgctagccagcgtggtgctgcccagccgtgccgagagggcgaggagcactcccagc
cctgtgccccagcctcgagactcctcatccacacttgagaagcagattggtgcttccacc
catggtgcagggggtgctgcggcaggaagcaggagcctcactgtggcgcccacaggtttc
tatgctggttcggtggccatcagtggggctctggccagcagcccagcacctctggcctct
ggaatggaatctgctgtttttgaggagtcctctggccccagcagcctctttggcaccatg
gggtctcgcagcacaccgccacaacatccacctctcctgccgcagtctcgcaactcgggc
cctgcctctcctgcccaccagctcgcagccagtccccgcctgagtgtgaccacccagggc
tcactgccagacaccggcaaaggggagctgcctgctgatcctgccttctcagacccagag
agtgaagctaagaggaggattgtgttcagcatttcagctggtgccagctccaggcagtcg
ccttccaccaggcacagccccttgacctctggcacccgtggggattgtgttcagagccat
gggcaggacagtcgtaagcgtagcagaaggaagcgtgcatcagctggaacgcctagcctc
accacgggtgtgtcccccaagcgccgagctctgccaaccgtcgctggcctctttacacag
tcttcggggtcgcctctcaatctcacctccatggtcagcaacatcaaccagcccctggag
atcacagccatctcatccccggagagctcactgaagagctcccccacaccctaccaggac
catgaccagcctccagtgctcaggaaggagcggcccctgggcccaactaatggggcccac
tactctccgctgacgtcagatgaggagccaggctcggaggacgagcccagcagtgcccga
attgagagaaaaattgcaacaatctctttagaaagcaaatctcccccgaagacactggaa
aatggtggtggcttagtgggaaggaagccggtcccctcaggcgagcctgtcaacagcagc
aaatggaagtccaccttctcacccatctccgacctcggcttggccaaggccatggacagt
ccgctacaggccagctctgcactgagccacagccccctcttctctttccggccgtccttg
gaggagcctgctgctgaggccaagccctccacccacccaaggaaaagttttgcgggctct
ctggctgcagctgaggggccaagccctggcaccaaccctcccaacagcctggccttcagt
gggggccttgctgcagacctcggtttacatagcttcaatgacggtgcttccctctcccac
aagggcccggaggtggcgggcctgagcgcctccctgagcttcccatcccagaggggcaag
gacagtaccacagaggccaaccccttcctcagcaggcggcagccggagggcctgggtggc
ctgaagggtgagggcaatgcaagcaaggagtcaggagagagcctgcccctgtgtgggccc
tcagacaaggtctcactgccacacggcagcagggccagcaaaggccgtgaccgcgagctg
gacttcaagggcggccacaacctcttcatctctgctgcagccgtgcctccaggtggcctc
cttggtggccctggtcttgtaactgtggcttcctctgcgggcagtgcgacaccctctgcc
caggctccccggcctttcctgagcacctttgcccctgggccccagtttactctgggcccc
atgtccctgcaggccaacctgggctctgtggccggctcctctgtgctgcagtccttgttc
agcactgtgccagctgctgcaggcctggtgcatgtgtcatccactgcgacccgactgacc
aactcacacaccatgggcagcttctcctctggggtggccggcggaaccgttggaggtaat
tag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (1)   
   Pfam (1)   
All databases (34)   

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