KEGG   Rattus norvegicus (rat): 50678
Entry
50678             CDS       T01003                                 
Symbol
Pde3a
Name
(RefSeq) cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
  KO
K19021  cGMP-inhibited 3',5'-cyclic phosphodiesterase A [EC:3.1.4.17]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00230  Purine metabolism
rno01100  Metabolic pathways
rno04022  cGMP-PKG signaling pathway
rno04024  cAMP signaling pathway
rno04924  Renin secretion
rno05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    50678 (Pde3a)
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    50678 (Pde3a)
   04022 cGMP-PKG signaling pathway
    50678 (Pde3a)
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    50678 (Pde3a)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    50678 (Pde3a)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.17  3',5'-cyclic-nucleotide phosphodiesterase
     50678 (Pde3a)
SSDB
Motif
Pfam: PDEase_I TgpA_N
Other DBs
NCBI-GeneID: 50678
NCBI-ProteinID: NP_059033
RGD: 61942
Ensembl: ENSRNOG00000025042
UniProt: Q62865
Position
4:175904276..176170531
AA seq 1141 aa
MAVRGEAAQDWAKPGLRGPSPAPVARGDHRCRGGSPSSPRGSGCCWRALALQPLRRSPQL
SSALCAGSLSVLLALLVRLVGGEVGGELESSQEAAAEEEEEEGARGGVFPGPRGGAPGGG
AQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDG
RLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVALTSALRTVALVSLERFKVAWRPYLAYL
AAVLGLLLARYAEQLLPQCSGPAPPRERFGSQSSARTKEEIPGWKRRRRSSSVVAGEMSG
CGGKSHRRTSLPCIPREQLMGHSEWDHKRGSRGSQSGTSVTVDIAVMGEAHGLITDLLAD
PSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKLAIPK
RLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWN
APVLMTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLDKISPVPSPSSSPPQGSPTSSPVS
GIASVQFPESPEVTTKRGPGSHRALTYTQSAPDLSPQIPPSPVICSSCGRPYSQGNPADG
PSERSGPAMQKPNRTDDTSQVTSDYETNNNSDSSDILQNDEEAECQREPLRKASACGTYT
PQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFE
DMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIG
DHGSASDSDSDSGFTHGHMGYVFSKAYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDH
PGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFL
VIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKDL
HLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAG
LMPGKWVDDSDDSGDTDDPEEEEEEAETPHEEETCENSEAPRKKSFKRRRIYCQITQHLL
QNHMMWKKVIEEEQCLSGTENQAPDQAPLQHSSEQIQAIKEEEEEKGKPRAEETLAPQPD
L
NT seq 3426 nt   +upstreamnt  +downstreamnt
atggcagtgcggggcgaggccgcccaagactgggccaagcccggtctccgagggccgagt
cctgccccggtggccagaggggaccaccgctgtcgtggcgggtccccttcatcccctcgg
ggctcgggctgttgttggcgagccctggcgttgcagcctctccggcgctcgccgcaactc
tcctccgcgttgtgcgcgggctccctgtccgtgctgctggcgctgctggtgaggctggtc
ggcggggaggtcggaggcgagctggagtcgagtcaggaggcggcggccgaggaggaggag
gaggaaggagcccgagggggcgtcttcccgggccctcggggaggtgctcccgggggcggc
gcgcagctcagcccttggctgcagccggccgcgctgctcttcagtctcctgtgcgccttc
ttctggatgggcttgtgcctgctgcgcgccggggtgcgcctgcctctggccgtcgcgctg
ttggccgcctgctgcgccggggaagcgctggtgcagctctccttgggcgtgggggacggt
cgcctgctgtcgctacccgccgcgggggtcctgctcagctgcctaggtggcgcgacatgg
ctggtgctgaggctgaggctgggcgtcctcatggtcgctttgactagcgccctcaggacg
gtggccctggtttctctggagaggttcaaggtcgcctggagaccttacctggcatacttg
gcggccgtgcttgggctgctgctggccaggtacgccgagcagctcctgccgcagtgctcc
gggccggctccgcccagggagcggtttgggtcccagtcgagcgcgaggaccaaggaagag
attccggggtggaagaggaggaggcggtccagctcggtggtggccggcgagatgtccggc
tgcggtggcaagtctcaccggaggacctccctgccctgcatacccagggagcagctcatg
ggccattcagaatgggaccacaagagagggtcacgaggatcccagtcaggaaccagcgtc
accgtggatattgccgtgatgggcgaggcgcatggcctcattaccgacctcctggccgac
ccttctttgcctccgaatgtgtgcacgtccttgagggccgtgagcaacctgctcagtacc
cagctcaccttccaggcaatccacaagcccagagtgaaccccactgtgaccttcagtgag
aactatacctgctccgactctgaggaaggcttggagaaagacaagctggccattcccaag
cgcctgagaagaagtttgcctccaggcttgctgaggagagtttcatcaacttggacaact
accacctctgccacaggactgcctaccttggagcctgcgccagtgcggagggaccgcagc
gccagcataaagccacatgaagccccttcacccagtgctgtcaaccctgactcttggaat
gccccagtgttgatgactctaaccaaaagcaggtccttcacttcgtcctatgctgtctct
gcagctaaccacgtcaaagctaaaaagcaaaacaggccaggtggccttgataagatttcg
cccgttccctcgccctcctcctcacctcctcaaggatcacccaccagcagtcctgtcagt
ggcattgcttccgtacagttcccggaatcccctgaagtcaccaccaaacgaggccctgga
tctcacagggccttaacttacacccagagtgcccctgacctgtccccccagatcccgccc
tcacctgtcatatgtagcagctgtggcagaccttactcacaagggaatcctgctgatgga
ccttcagagagaagtggcccagccatgcagaaaccaaacagaacagatgatacttctcaa
gttacctctgattatgagaccaacaacaacagtgacagcagcgacatcctgcagaatgat
gaggaagccgagtgccagagagagccactgaggaaagcatcggcttgtggcacctatact
ccccagaccatgatcttcctggacaaaccaattcttgctccagaacccctggtcatggat
aacctggattcaattatggatcagttgaacacctggaattttccaatttttgatttagtg
gaaaacataggaagaaaatgtggccgtattctgagccaggtgtcatacagactctttgaa
gacatggggctctttgaagcctttaaaatcccggttagggagtttatgaattactttcat
gctttggagatcggctacagggacattccttatcataacagaatccacgccactgatgtt
ttgcacgccgtgtggtatctcacaacacagccgattcctggcctcccgagtgtgattggt
gatcacggctcggcaagtgactctgattctgacagtgggtttacacacggacacatggga
tatgtgttttccaaagcgtatcatgtgccagatgacaaatatggatgcctgtctggaaat
attccagccctggagttgatggccctgtatgttgctgcagccatgcatgactacgatcac
ccaggaaggacaaatgctttcctggttgccactagcgcccctcaggccgtgctgtacaat
gaccgttccgttctggagaaccatcacgcagctgcagcctggaatctcttcatgtcccgg
ccggagtataacttcttagttaacctggaccatgtggaatttaagcacttccgattccta
gtcattgaagcaattctggctactgacctgaagaaacactttgactttgtagccaagttt
aatgccaaggtgaatgatgatgttgggatagattggaccaatgaaaacgaccgtctcctg
gtgtgtcagatgtgtataaagttggctgacatcaacgggcctgctaaatgtaaggacctc
cacctgcggtggacggagggcatcgccagcgagttttatgagcagggcgatgaagaagcc
agccttggtttgcccataagcccatttatggaccgctctgccccgcagctggccaatctt
caggagtcctttatctcacacatcgtgggtcctctttgccactcctacgactctgcgggt
ctcatgccgggaaaatgggtagatgacagtgatgattcaggagacactgatgacccggaa
gaagaggaggaagaggctgaaacaccacacgaggaagaaacctgtgaaaacagtgaagct
cccagaaagaaaagtttcaaaagaaggagaatctactgtcaaataactcagcaccttctg
cagaaccacatgatgtggaagaaagtgattgaagaggagcagtgtttatcaggcacagag
aaccaggccccagaccaggcaccgctgcagcattcctcagaacaaatccaggctatcaag
gaggaggaggaagagaaggggaagccaagagcagaggaaaccctcgctccacaaccagac
ctgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (2)   
   Pfam (2)   
All databases (33)   

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