KEGG   Rattus norvegicus (rat): 54244
Entry
54244             CDS       T01003                                 
Symbol
Crebbp
Name
(RefSeq) histone lysine acetyltransferase CREBBP
  KO
K04498  E1A/CREB-binding protein [EC:2.3.1.48]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno03083  Polycomb repressive complex
rno03250  Viral life cycle - HIV-1
rno04024  cAMP signaling pathway
rno04066  HIF-1 signaling pathway
rno04068  FoxO signaling pathway
rno04110  Cell cycle
rno04310  Wnt signaling pathway
rno04330  Notch signaling pathway
rno04350  TGF-beta signaling pathway
rno04520  Adherens junction
rno04630  JAK-STAT signaling pathway
rno04720  Long-term potentiation
rno04916  Melanogenesis
rno04919  Thyroid hormone signaling pathway
rno04922  Glucagon signaling pathway
rno04935  Growth hormone synthesis, secretion and action
rno05016  Huntington disease
rno05152  Tuberculosis
rno05161  Hepatitis B
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05206  MicroRNAs in cancer
rno05211  Renal cell carcinoma
rno05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    54244 (Crebbp)
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    54244 (Crebbp)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    54244 (Crebbp)
   04330 Notch signaling pathway
    54244 (Crebbp)
   04350 TGF-beta signaling pathway
    54244 (Crebbp)
   04630 JAK-STAT signaling pathway
    54244 (Crebbp)
   04066 HIF-1 signaling pathway
    54244 (Crebbp)
   04068 FoxO signaling pathway
    54244 (Crebbp)
   04024 cAMP signaling pathway
    54244 (Crebbp)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    54244 (Crebbp)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    54244 (Crebbp)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    54244 (Crebbp)
   04935 Growth hormone synthesis, secretion and action
    54244 (Crebbp)
   04919 Thyroid hormone signaling pathway
    54244 (Crebbp)
   04916 Melanogenesis
    54244 (Crebbp)
  09156 Nervous system
   04720 Long-term potentiation
    54244 (Crebbp)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    54244 (Crebbp)
   05206 MicroRNAs in cancer
    54244 (Crebbp)
   05203 Viral carcinogenesis
    54244 (Crebbp)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    54244 (Crebbp)
   05215 Prostate cancer
    54244 (Crebbp)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    54244 (Crebbp)
   05161 Hepatitis B
    54244 (Crebbp)
   05164 Influenza A
    54244 (Crebbp)
   05167 Kaposi sarcoma-associated herpesvirus infection
    54244 (Crebbp)
   05165 Human papillomavirus infection
    54244 (Crebbp)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    54244 (Crebbp)
  09164 Neurodegenerative disease
   05016 Huntington disease
    54244 (Crebbp)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:rno03000]
    54244 (Crebbp)
   03036 Chromosome and associated proteins [BR:rno03036]
    54244 (Crebbp)
   03029 Mitochondrial biogenesis [BR:rno03029]
    54244 (Crebbp)
Enzymes [BR:rno01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.48  histone acetyltransferase
     54244 (Crebbp)
Transcription factors [BR:rno03000]
 Eukaryotic type
  Other transcription factors
   Pocket domain CBP
    54244 (Crebbp)
Chromosome and associated proteins [BR:rno03036]
 Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    54244 (Crebbp)
Mitochondrial biogenesis [BR:rno03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Coactivators
    54244 (Crebbp)
SSDB
Motif
Pfam: HAT_KAT11 KIX Creb_binding zf-TAZ RING_CBP-p300 Bromodomain ZZ KIX_2 Npa1
Other DBs
NCBI-GeneID: 54244
NCBI-ProteinID: NP_596872
RGD: 2401
Ensembl: ENSRNOG00000005330
UniProt: F1M9G7
Position
10:11842307..11968266
AA seq 2444 aa
MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGELSLLNSGNLVP
DAASKHKQLSELLRGGSGSSITPGIGNVSASSPVQQGLGGQAQGQPNSTSMASLGAMGKS
PLNPGDSSTPSLPKQAASTSGPTPPASQALNPQAQKQVGLVTSSPATSQTGPGICMNANF
NQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSSVLAE
TLTQVSPQMAGHAGLNTAQAGGMTKMGMTGNTSPFGQPFSQTGGQPMGATGVNPQLASKQ
SMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIVPAQGIATGPTADPEKRKLIQQQLVLL
LHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKN
CTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGAGQQNATSLSNPNPIDPSSM
QRAYAALGLPYMNQPQTQLQPQVPGQQPAQPPAHQQMRTLNALGNNPMSIPAGGITTDQQ
PPNLISESALPTSLGATNPLMNDGSNSGSIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLR
SHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKI
QKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPPTQSVRPPNGPLSLPVNRVQVSQGM
NSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHAN
NIMAQAPTQNQFLPQNQFPSSSGAMSVNSVGMGQPATQAGVSQGQVPGGTLPNPLNMLAP
QTSQLPCPPVTQSPLHPTPPPASTAAGMPSLQHPTPPGMTPPQPAAPTQPSTPVSSGQTP
TPTPGSVPSAAQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGT
PLSQAAASIDNRVPTPSSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPDPAESKGEPRS
EMMEEDLQGSSQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSANGTASQSTSPSQ
PRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIK
RKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYC
CGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQ
TTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPR
KENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRF
VDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHF
FRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRL
QEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEESIKELEQE
EEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQ
KLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFS
SLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHT
HKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMK
RVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRL
QQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVNMSPA
GFPSVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINN
GMPPGRAGMGTPGSQMAPVGLNVPRPNQVSGPVMSSMPPGQWQQAPIPQQQPMPGMPRPV
MSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA
FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPPQQ
AMGGLNPQGQALNIMNPGHNPNMANMNPQYREMVRRQLLQHQQQQQQQQQQQQQQQQQQS
SASLAGGMAGHSQFQQPQGPGGYAPAMQQQRMQQHLPIQGSSMGQMAAPMGQLGQMGQPG
LGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATS
LSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSMDQG
HLGNPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKFVEGL
NT seq 7335 nt   +upstreamnt  +downstreamnt
atggccgagaacttgctggacggaccgcccaaccccaaacgagccaaactcagctcgccc
ggcttctccgcgaatgacagcacagattttggatcattgtttgacttggaaaatgatctt
cctgatgagctgatccccaatggagaattaagccttttaaacagtgggaaccttgttcca
gatgctgcgtccaaacataaacaactgtcagagcttcttagaggaggcagcggctctagc
atcacccccgggataggcaatgtgagtgccagcagccctgtgcagcagggccttggtggc
caggctcaggggcagccgaacagtacaagcatggccagtttaggtgccatgggcaagagc
cctctgaacccaggagactcatcaacacccagcctgcccaaacaggcagccagcacctct
gggcccactccccctgcctcccaagcactgaatccgcaagcacaaaagcaagtggggctg
gtgaccagtagtcctgccacatcacagactggacctgggatctgcatgaatgctaacttc
aaccagacccacccaggccttctcaatagtaactctggccatagcttaatgaatcaggct
caacaagggcaagctcaagtcatgaatggatctcttggggctgctggaagaggaagggga
gctggaatgccctaccctgctccagccatgcagggggccacaagcagtgtgctggctgag
actttgacacaggtttctccacaaatggctggccatgctggactgaatacggcacaggca
ggaggcatgaccaagatggggatgactggtaacacaagtccgtttggacaaccctttagt
caaactggagggcagccgatgggagccactggagtgaaccctcagttagccagcaaacag
agcatggtcaatagtttgcctgcttttcctacagatatcaagaatacttcagtcaccact
gtgccaaatatgtcccagttgcaaacatcagtgggaattgtacccgcacaaggaattgca
accggccccacagcagaccctgagaagcgcaaactgatacagcagcagctggttctactg
cttcatgcccacaaatgtcagcgacgagagcaagcgaatggagaggttcgggcctgttct
ctcccacactgtcgaaccatgaaaaatgttttgaatcacatgacacattgtcaggctggg
aaagcctgccaagttgcccattgtgcatcttcacgacaaatcatctctcattggaagaac
tgcacacgacatgactgtcctgtttgcctccctttgaaaaatgccagtgacaagcgaaac
caacaaaccatcctgggatctccagctagtggaattcaaaacacaattggttctgttggt
gcagggcaacagaatgccacttctttaagtaacccaaatcccatagaccccagttccatg
cagcgggcctatgctgctctaggactcccctacatgaaccagcctcagacgcagctgcag
cctcaggttcctggccagcaaccagcacaacctccagcccaccagcagatgaggactctg
aatgctctaggaaacaacccaatgagtattccagcaggaggaataacaacagatcagcag
ccgccaaacttgatttcagaatcagctcttccaacttctttgggggctaccaatccgctg
atgaatgatggctccaactctggtagcattggaagcctcagcacgatacccacagcagca
cctccttccagcactggtgttcgaaaaggctggcatgaacatgtgactcaggacctgcgg
agccatctagtgcataaactcgttcaagccatcttcccgactcctgacccggcagctctg
aaggatcgccgcatggagaacctggttgcctatgctaagaaagtggagggagacatgtat
gagtctgctaatagcagggatgaatactatcatttattagcagagaaaatctataaaata
caaaaagaactagaagaaaaacgaaggtcacgtttacataagcaaggcatcctgggtaac
cagccagcattaccagctcctggggctcagccccctgtgatcccaccaacccagtctgtg
agacctccaaatgggcccctgtctttgccagtgaatcgtgtgcaggtttctcaaggaatg
aattcatttaacccaatgtccctggggaacgtccagttgccacaggcacccatgggacct
cgcgcagcctcccccatgaaccactctgtccagatgaacagcatggcctcagttccgggt
atggccatttctccttcccggatgcctcagcctcccaatatgatgggcacccatgccaac
aacattatggcccaggcacctactcagaaccagtttctgccacagaaccagtttccatca
tccagtggggcaatgagtgtgaacagtgtaggcatggggcagcccgcaacccaggcaggt
gtttcacagggccaggtgcctggaggtacacttcctaaccctctgaacatgctggcgccc
cagaccagccagcttccttgcccaccagtgacacagtcacctttgcacccgactccacct
cctgcttccacagctgctggcatgccctctctccagcatccgacaccaccagggatgacc
cctccccagccagcagctcccactcagccatccactcctgtgtcatctgggcagactcct
accccaactcctggctcagtgcccagtgctgcccaaacacagagcaccccaacagtgcag
gcagcagcacaggctcaggtgaccccacagcctcagactccagtgcagccaccatctgtg
gccactcctcagtcatcacagcagcaaccaacgcctgtgcatactcagcctcctggcaca
ccgctttctcaggcagcagccagcattgataatagagtccctactccctcctctgtgacc
agtgctgaaaccagttcccagcagccaggacctgatgtgcccatgctggaaatgaagaca
gaggtgcagacagatgatgctgaacctgatcctgctgaatccaagggggaaccccgctct
gagatgatggaagaggatttacaaggttcttcccaagtaaaagaagaaacagatacaaca
gagcagaagtcagaaccaatggaagtagaagaaaagaaacccgaagtaaaagtggaagct
aaagaggaagaagagaacagtgctaacggcacagcctcacagtcaacatccccttcccag
ccacgcaaaaaaatctttaaacctgaggagctacgccaggcactcatgccaactctagaa
gcactctatcgacaggacccagagtctctgccttttcggcagcctgtagatcctcagctc
ctaggaatcccagattattttgatattgtgaagaatcctatggacctttctaccatcaag
cgaaagctggacacagggcaatatcaagaaccctggcagtatgtggacgatgtctggctt
atgttcaacaatgcgtggctgtataatcgtaagacgtcccgggtatataaattttgcagt
aaacttgcagaggtctttgaacaagaaattgaccctgtcatgcagtctcttggatattgc
tgtggccgaaagtatgagttctccccacagactttgtgctgctatggaaagcagctgtgt
acaattcctcgtgatgcagcctactacagctatcagaataggtatcatttctgtgagaag
tgtttcacagagatccagggcgagaatgtgaccctgggtgacgacccttcccaacctcag
acgacaatttccaaggatcaatttgaaaagaagaaaaatgacaccttagatcctgaaccc
tttgttgactgcaaagagtgtggccggaagatgcatcagatttgcgttctacactatgac
atcatttggccttcaggttttgtgtgtgacaactgcttgaagaaaactggcagacctcgg
aaagaaaacaaattcagtgctaagaggctgcagaccacacggttgggaaaccatttggaa
gaccgagtgaacaagtttttgcggcgccagaatcaccctgaagctggggaggtttttgtc
agagtggtggccagctcagacaagactgtggaggtcaagccaggaatgaagtcaaggttt
gtggattctggagaaatgtctgaatctttcccatatcgtaccaaagcactcttcgctttt
gaggagattgatggagtcgatgtgtgcttttttgggatgcatgtacaagaatatggctcc
gattgccccccacctaatacaaggcgcgtctatatatcttatctggacagtattcatttc
ttccggccccgctgtctccgcaccgctgtttaccatgagatcctcattggatatctagag
tatgtgaagaaattggggtatgtgacaggacacatttgggcctgtcccccaagtgaagga
gatgactacatctttcattgccacccccctgaccagaaaatccccaaaccaaaacgacta
caggagtggtacaagaagatgctggacaaggcattcgcagagaggatcattaacgactat
aaggacatcttcaaacaagcgaacgaagacaggctcacgagtgccaaggagttgccctat
ttcgaaggagatttctggcctaatgtgttggaagaaagcattaaggagctagaacaagaa
gaagaagaaaggaagaaagaagagagtactgcagcgagtgagactcctgagggcagtcag
ggtgacagcaagaatgccaagaaaaagaacaacaagaagaccaacaaaaacaaaagcagc
attagccgcgccaacaagaagaagcccagcatgcccaatgtttccaacgacctgtcgcag
aagctgtatgctaccatggagaagcacaaggaggtcttctttgtgatccacctgcatgct
gggcctgtcatcagcactcagccccccatcgtggaccctgatcccctgcttagctgtgac
ctcatggacgggcgggatgccttcctcaccctggccagagacaagcactgggagttctct
tccttacgccgctccaaatggtccactctgtgcatgctggtggagctgcacacacagggc
caggaccgctttgtctatacctgcaacgagtgcaaacaccatgtagaaacacgctggcac
tgcactgtgtgtgaggactatgacctttgtatcaattgctacaacacaaagagccacacc
cataagatggtgaagtgggggctaggcctagatgatgagggcagcagtcagggtgagcca
cagtccaagagcccccaggaatcccggcgtctcagcatccaacgctgcatccagtccctg
gtgcatgcctgccagtgtcgcaatgccaactgctcgctgccatcttgccagaagatgaag
cgagtcgtgcagcacaccaagggctgcaagcgcaagactaatggaggctgcccagtgtgt
aagcagctcattgctctttgctgctaccacgccaaacactgccaagaaaataaatgccct
gtgcccttctgcctcaacatcaaacacaagctccgccagcagcagatccagcatcgcctg
cagcaggctcagctcatgcgccggcgaatggcaaccatgaacacccgcaatgtgcctcag
cagagtttgccttctcctacctcagcaccacccgggactcctacacagcagcccagcaca
ccccaaacaccacagcccccagcccagcctcagccttcacctgtaaacatgtcaccagct
ggcttccccagtgtagcccggactcagccccccacaatagtgtctgctgggaagcctacc
aaccaggtgccagctcccccaccccctgcccagcccccacctgcagcagtggaagcagcc
aggcaaattgaacgtgaggcccagcagcagcagcacctgtaccgagcaaacatcaacaat
ggcatgcccccagggcgtgcaggtatggggaccccaggaagccagatggctcctgtgggc
ctgaatgtgccccgtcccaaccaagtcagtgggcctgtcatgtctagcatgccacctggg
cagtggcagcaggcacccatccctcagcagcagccgatgccaggcatgcccaggcctgta
atgtccatgcaggcccaggcagcggtggctgggccacggatgcccaatgtacagccacca
aggagcatctcgccaagtgccctgcaagacctgcttcggaccctaaagtcacccagctct
cctcagcagcagcagcaggtgctgaacatcctcaaatcaaacccacagctaatggcagct
ttcatcaaacagcgcacagccaagtatgtggccaatcagcctggcatgcagccccagccc
ggacttcaatcccagcctggtatgcagccccagcctggcatgcaccagcagcccagcctg
caaaacctgaacgcaatgcaagctggtgtgccacggcctggtgtgcctccaccacagcag
gcaatgggaggcctgaacccccagggtcaggctctgaatatcatgaacccgggacacaac
cccaacatggcgaacatgaatccgcagtaccgagaaatggtgagaagacagctgctacag
caccaacagcagcagcagcagcagcagcagcagcagcagcaacagcaacagcaacaaagc
agtgccagcttggccgggggcatggcaggacacagccagttccagcagccacaaggacct
ggaggctacgccccagccatgcagcagcaacgcatgcaacagcacctccccatccagggc
agctccatgggccagatggctgctccaatgggacaacttggccagatggggcagcctggg
ctaggggcagacagcacccctaatatccagcaggccctgcagcagcggattctgcagcag
cagcagatgaagcaacaaattgggtcaccaggccagccgaaccccatgagcccccagcag
cacatgctctcaggacagccacaggcttcacatctccctggccagcagatcgccacatcc
cttagtaaccaggtgcggtctccagcccctgtgcagtctccacggccccaatcccaacct
ccacattccagcccgtcaccacggatacagccccagccttcaccacaccatgtttcaccc
cagactggttcccctcaccctggacttgcagtcaccatggccagctccatggatcaggga
cacctggggaaccctgaacagagtgcaatgctcccccagctgaatacccccaacaggagc
gcgctgtccagtgaactgtccctggttggtgataccacgggagacacgctagaaaagttt
gtggagggcttgtag

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (1)   
   RefSeq(pep) (5)   
DNA sequence (11)   
   RefSeq(nuc) (5)   
   GenBank (3)   
   EMBL (3)   
Protein domain (9)   
   Pfam (9)   
All databases (67)   

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