KEGG   Rattus norvegicus (rat): 57027
Entry
57027             CDS       T01003                                 
Symbol
Adam17
Name
(RefSeq) disintegrin and metalloproteinase domain-containing protein 17 precursor
  KO
K06059  disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04148  Efferocytosis
rno04330  Notch signaling pathway
rno05010  Alzheimer disease
rno05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    57027 (Adam17)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    57027 (Adam17)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    57027 (Adam17)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    57027 (Adam17)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:rno01002]
    57027 (Adam17)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:rno04090]
    57027 (Adam17)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     57027 (Adam17)
Peptidases and inhibitors [BR:rno01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   57027 (Adam17)
CD molecules [BR:rno04090]
 Proteins
  57027 (Adam17)
SSDB
Motif
Pfam: Reprolysin_2 Reprolysin_5 ADAM17_MPD Disintegrin Reprolysin_3 Reprolysin Reprolysin_4 Pep_M12B_propep
Other DBs
NCBI-GeneID: 57027
NCBI-ProteinID: NP_064702
RGD: 620404
Ensembl: ENSRNOG00000060694
UniProt: Q9Z1K9
Position
6:complement(46601583..46663690)
AA seq 827 aa
MRQRLLFLTTLVPFVLAPRPPEEPGSGSHPRLEKLDSLLSDYDILSLSNIQQHSIRKRDL
QSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQDFFSGHVV
GEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQS
PKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNM
AKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACADTDNSC
KVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMD
SASVRIIKPFPAPQTPGRLQALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGF
EKDPFPNSSAAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC
NT seq 2484 nt   +upstreamnt  +downstreamnt
atgaggcagcgtctcctcttcctgaccactttggtgcctttcgtcctggcaccccgacct
ccggaggaaccaggctctggctcccacccgcgacttgagaagcttgattctttgctctca
gactacgatatcctctctttatctaatatccagcagcactccataaggaaaagggatcta
cagtctgcgacacacttagaaacactactaactttttcagctttgaaaaggcattttaaa
ttatacttgacatcaagtacagaacgcttttcacagaacttgcgagtcgtggtggtggat
gggaaagaggaaagcgagtacagtgtgaagtggcaggacttcttcagcggacatgtggtt
ggtgagcctgactctagggttctagcgcacataggagatgatgatgtcacagtaagaatc
aacacagatggggcagaatataacatagagccactttggaggtttgttaatgatactaaa
gataaaaggatgctggtgtataagtctgaagatatcaaggatttttcacgtttgcagtct
ccaaaagtatgtggttatttaaatgcagatagtgaagagttgcttccaaaagggctcata
gacagagagccatctgaagagtttgtccgtcgagtgaagaggcgagctgaacctaaccca
ttgaagaatacttgtaaattactggtggtggcagatcatcgattttataagtacatgggc
cgaggagaagagagcactactacaaattacttaatagagttaattgaccgagttgatgac
atataccggaacacctcgtgggacaatgcaggatttaaaggttatggagtacagatagaa
cagattcgaattctcaagtctccacaagaggtaaaacctggtgaaagacacttcaatatg
gcaaaaagttttccaaatgaagaaaaggatgcttgggatgtgaagatgctgctggagcaa
tttagccttgatatagctgaagaggcctctaaagtctgcctggctcatcttttcacctac
caagattttgatatgggaactcttggattagcttacgttggttctcccagagcaaacagt
catggaggggtttgtccaaaagcttattacaacccaggtgtgaagaagaacatctatttg
aatagtggtctgacaagtacaaaaaattatggtaaaaccatccttacaaaggaggctgac
ctggttacaactcatgaattgggacacaattttggagcagaacatgatcctgatgggctg
gcagagtgtgccccaaatgaggaccaaggaggaaagtatgttatgtaccccatagctgtg
agtggtgaccatgagaataataagatgttttcaaactgcagtaaacagtccatctacaag
accatagaaagcaaggctcaagagtgcttccaggagcgcagcaacaaggtgtgcggcaac
tccagggtggacgaaggagaagagtgtgacccgggcatcatgtacctgaacaacgacacc
tgctgcaatagtgactgcacactgaagccaggtgtgcagtgcagtgataggaatagtcct
tgctgtaaaaattgtcagtttgagacggcccagaagaagtgccaggaggctatcaatgct
acttgcaaaggagtgtcttactgcacagggaatagcagtgagtgccccccaccaggagat
gctgaagatgacactgtgtgcttggacctgggcaagtgcaaggctgggaaatgcatccct
ttctgcaagagggagcaggagctggagtcctgcgcatgtgctgacaccgacaactcgtgc
aaggtatgctgcaggaacctttctggcccatgtgtgccttacgtcgatgcagagcaaaag
aacttatttttgaggaaagggaagccctgtacagtagggttttgtgacatgaatggcaaa
tgtgagaaacgggtacaggacgtaattgagcggttttgggatttcattgaccagctgagc
atcaacacttttgggaagtttctggcagacaacatcgttgggtctgttctggttttctcc
ttgatattttggattcctttcagcattcttgtccactgtgtggataagaaactggacaag
cagtatgagtccctgtctctgtttcatcacagtaacattgagatgttgagcagcatggac
tcagcatctgttcgcattatcaagccgttccctgcaccccagactccaggtcgtctgcag
gccctgcagccggctgcaatgatgccgccagtgtctgcggctccaaaactggatcaccag
aggatggacaccatccaggaagaccccagcacagattcacatgtggatgatgatggcttt
gagaaggaccccttccccaacagcagtgcagccgccaagtcctttgaggacctcacagac
cacccagtcaccaggagtgagaaggccgcctccttcaagctgcagcgtcagagccgagtt
gacagcaaagagacagagtgttag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (8)   
   Pfam (8)   
All databases (36)   

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