KEGG   Rattus norvegicus (rat): 58960
Entry
58960             CDS       T01003                                 
Symbol
Map2k2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04024  cAMP signaling pathway
rno04066  HIF-1 signaling pathway
rno04068  FoxO signaling pathway
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04140  Autophagy - animal
rno04148  Efferocytosis
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04218  Cellular senescence
rno04270  Vascular smooth muscle contraction
rno04370  VEGF signaling pathway
rno04371  Apelin signaling pathway
rno04540  Gap junction
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04613  Neutrophil extracellular trap formation
rno04620  Toll-like receptor signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04720  Long-term potentiation
rno04722  Neurotrophin signaling pathway
rno04730  Long-term depression
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04916  Melanogenesis
rno04917  Prolactin signaling pathway
rno04919  Thyroid hormone signaling pathway
rno04921  Oxytocin signaling pathway
rno04926  Relaxin signaling pathway
rno04929  GnRH secretion
rno04934  Cushing syndrome
rno04935  Growth hormone synthesis, secretion and action
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05132  Salmonella infection
rno05135  Yersinia infection
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05170  Human immunodeficiency virus 1 infection
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05207  Chemical carcinogenesis - receptor activation
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05216  Thyroid cancer
rno05218  Melanoma
rno05219  Bladder cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05230  Central carbon metabolism in cancer
rno05231  Choline metabolism in cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    58960 (Map2k2)
   04012 ErbB signaling pathway
    58960 (Map2k2)
   04014 Ras signaling pathway
    58960 (Map2k2)
   04015 Rap1 signaling pathway
    58960 (Map2k2)
   04370 VEGF signaling pathway
    58960 (Map2k2)
   04371 Apelin signaling pathway
    58960 (Map2k2)
   04066 HIF-1 signaling pathway
    58960 (Map2k2)
   04068 FoxO signaling pathway
    58960 (Map2k2)
   04072 Phospholipase D signaling pathway
    58960 (Map2k2)
   04071 Sphingolipid signaling pathway
    58960 (Map2k2)
   04024 cAMP signaling pathway
    58960 (Map2k2)
   04022 cGMP-PKG signaling pathway
    58960 (Map2k2)
   04151 PI3K-Akt signaling pathway
    58960 (Map2k2)
   04150 mTOR signaling pathway
    58960 (Map2k2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    58960 (Map2k2)
   04148 Efferocytosis
    58960 (Map2k2)
  09143 Cell growth and death
   04210 Apoptosis
    58960 (Map2k2)
   04218 Cellular senescence
    58960 (Map2k2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    58960 (Map2k2)
   04550 Signaling pathways regulating pluripotency of stem cells
    58960 (Map2k2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    58960 (Map2k2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    58960 (Map2k2)
   04620 Toll-like receptor signaling pathway
    58960 (Map2k2)
   04650 Natural killer cell mediated cytotoxicity
    58960 (Map2k2)
   04660 T cell receptor signaling pathway
    58960 (Map2k2)
   04662 B cell receptor signaling pathway
    58960 (Map2k2)
   04664 Fc epsilon RI signaling pathway
    58960 (Map2k2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    58960 (Map2k2)
   04929 GnRH secretion
    58960 (Map2k2)
   04912 GnRH signaling pathway
    58960 (Map2k2)
   04915 Estrogen signaling pathway
    58960 (Map2k2)
   04917 Prolactin signaling pathway
    58960 (Map2k2)
   04921 Oxytocin signaling pathway
    58960 (Map2k2)
   04926 Relaxin signaling pathway
    58960 (Map2k2)
   04935 Growth hormone synthesis, secretion and action
    58960 (Map2k2)
   04919 Thyroid hormone signaling pathway
    58960 (Map2k2)
   04916 Melanogenesis
    58960 (Map2k2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    58960 (Map2k2)
  09156 Nervous system
   04720 Long-term potentiation
    58960 (Map2k2)
   04730 Long-term depression
    58960 (Map2k2)
   04722 Neurotrophin signaling pathway
    58960 (Map2k2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    58960 (Map2k2)
   05206 MicroRNAs in cancer
    58960 (Map2k2)
   05205 Proteoglycans in cancer
    58960 (Map2k2)
   05207 Chemical carcinogenesis - receptor activation
    58960 (Map2k2)
   05208 Chemical carcinogenesis - reactive oxygen species
    58960 (Map2k2)
   05230 Central carbon metabolism in cancer
    58960 (Map2k2)
   05231 Choline metabolism in cancer
    58960 (Map2k2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    58960 (Map2k2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    58960 (Map2k2)
   05225 Hepatocellular carcinoma
    58960 (Map2k2)
   05226 Gastric cancer
    58960 (Map2k2)
   05214 Glioma
    58960 (Map2k2)
   05216 Thyroid cancer
    58960 (Map2k2)
   05221 Acute myeloid leukemia
    58960 (Map2k2)
   05220 Chronic myeloid leukemia
    58960 (Map2k2)
   05218 Melanoma
    58960 (Map2k2)
   05211 Renal cell carcinoma
    58960 (Map2k2)
   05219 Bladder cancer
    58960 (Map2k2)
   05215 Prostate cancer
    58960 (Map2k2)
   05213 Endometrial cancer
    58960 (Map2k2)
   05224 Breast cancer
    58960 (Map2k2)
   05223 Non-small cell lung cancer
    58960 (Map2k2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    58960 (Map2k2)
   05170 Human immunodeficiency virus 1 infection
    58960 (Map2k2)
   05161 Hepatitis B
    58960 (Map2k2)
   05160 Hepatitis C
    58960 (Map2k2)
   05164 Influenza A
    58960 (Map2k2)
   05163 Human cytomegalovirus infection
    58960 (Map2k2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    58960 (Map2k2)
   05165 Human papillomavirus infection
    58960 (Map2k2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    58960 (Map2k2)
   05135 Yersinia infection
    58960 (Map2k2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    58960 (Map2k2)
   05022 Pathways of neurodegeneration - multiple diseases
    58960 (Map2k2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    58960 (Map2k2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    58960 (Map2k2)
   01522 Endocrine resistance
    58960 (Map2k2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    58960 (Map2k2)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     58960 (Map2k2)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: STE group
  STE7 family
   58960 (Map2k2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 APH Kdo
Other DBs
NCBI-GeneID: 58960
NCBI-ProteinID: NP_579817
RGD: 61888
Ensembl: ENSRNOG00000020005
UniProt: P36506 A6K8C5
Position
7:complement(9241449..9264216)
AA seq 400 aa
MLARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEELDLDEQQRKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADL
KLLTNHAFIKRSEGEDVDFAGWLCRTLRLKQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgttaccggcgctcaccatcaaccctaccatcgctgag
ggcccgtcccccaccagcgagggcgcctccgaggcacacctggtggacctccagaagaag
ttggaagagctggacctggatgaacagcagaggaagcggctggaggccttccttacccag
aaggccaaggttggtgagctcaaggacgacgactttgagagaatctcagaactgggtgca
ggcaatggcggcgtggtcacaaaggcccggcataggccctctggcctcatcatggccaga
aagctgatccacctggagatcaagccagctgtccgcaaccagatcatccgggagctgcag
gtgctgcatgagtgcaactcaccgtacatcgtgggcttttatggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggacggtggctcactggaccaggtactgaag
gaggccaagcgcattcccgaggacatcttagggaaggtcagcattgcggtgctccggggc
ctggcgtacctccgcgagaagcaccagatcatgcatagagatgtgaagccctccaacatt
ctggtgaactctcgtggagagattaagctgtgcgacttcggagtgagcggccagttgatt
gactccatggccaactcatttgtagggacacgctcctacatgtccccagaacggctgcag
ggcacccactactctgtgcagtcggacatctggagcatggggctgtcgctggtggagctg
gccatcgggaggtaccccatccccccacctgatgccaaggaactagaggccagctttggc
cggcctgtggtggacggggcagatggagagccccatagtgtctcaccgcggccccggccc
cctggacgccccatcagtggtcatgggatggacagccgaccagccatggccatctttgag
ctgctggactacatagtgaatgagccacctcccaagctgcccagtggtgtgttcagctca
gacttccaggagtttgtgaataaatgtctcattaagaacccagcagagcgtgcagacctc
aagctgctgacgaaccatgccttcatcaaacgctctgagggggaggacgtggacttcgct
ggctggctatgcagaaccctgcggctgaagcagcccagcacacccacgcgtactgcagtg
tga

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