KEGG   Rattus norvegicus (rat): 64363
Entry
64363             CDS       T01003                                 
Symbol
Araf
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform 1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04068  FoxO signaling pathway
rno04270  Vascular smooth muscle contraction
rno04650  Natural killer cell mediated cytotoxicity
rno04720  Long-term potentiation
rno04726  Serotonergic synapse
rno04730  Long-term depression
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04928  Parathyroid hormone synthesis, secretion and action
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05034  Alcoholism
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05212  Pancreatic cancer
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05218  Melanoma
rno05219  Bladder cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    64363 (Araf)
   04012 ErbB signaling pathway
    64363 (Araf)
   04068 FoxO signaling pathway
    64363 (Araf)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    64363 (Araf)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    64363 (Araf)
  09152 Endocrine system
   04910 Insulin signaling pathway
    64363 (Araf)
   04914 Progesterone-mediated oocyte maturation
    64363 (Araf)
   04928 Parathyroid hormone synthesis, secretion and action
    64363 (Araf)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    64363 (Araf)
  09156 Nervous system
   04726 Serotonergic synapse
    64363 (Araf)
   04720 Long-term potentiation
    64363 (Araf)
   04730 Long-term depression
    64363 (Araf)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    64363 (Araf)
   05205 Proteoglycans in cancer
    64363 (Araf)
   05208 Chemical carcinogenesis - reactive oxygen species
    64363 (Araf)
  09162 Cancer: specific types
   05210 Colorectal cancer
    64363 (Araf)
   05212 Pancreatic cancer
    64363 (Araf)
   05225 Hepatocellular carcinoma
    64363 (Araf)
   05226 Gastric cancer
    64363 (Araf)
   05214 Glioma
    64363 (Araf)
   05221 Acute myeloid leukemia
    64363 (Araf)
   05220 Chronic myeloid leukemia
    64363 (Araf)
   05218 Melanoma
    64363 (Araf)
   05211 Renal cell carcinoma
    64363 (Araf)
   05219 Bladder cancer
    64363 (Araf)
   05215 Prostate cancer
    64363 (Araf)
   05213 Endometrial cancer
    64363 (Araf)
   05224 Breast cancer
    64363 (Araf)
   05223 Non-small cell lung cancer
    64363 (Araf)
  09172 Infectious disease: viral
   05161 Hepatitis B
    64363 (Araf)
   05160 Hepatitis C
    64363 (Araf)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    64363 (Araf)
   05022 Pathways of neurodegeneration - multiple diseases
    64363 (Araf)
  09165 Substance dependence
   05034 Alcoholism
    64363 (Araf)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    64363 (Araf)
   01522 Endocrine resistance
    64363 (Araf)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    64363 (Araf)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     64363 (Araf)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   64363 (Araf)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 64363
NCBI-ProteinID: NP_071977
RGD: 2148
Ensembl: ENSRNOG00000010838
UniProt: P14056 A6JZR6
Position
X:complement(3780932..3845919)
AA seq 604 aa
MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEVPSNLSVNELL
TPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFS
TDAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYY
WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTR
HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA
KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQD
PNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAM
RRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAA
RLVP
NT seq 1815 nt   +upstreamnt  +downstreamnt
atggaaccaccacgaggccctcctgctagtggggctgagccatctcgggcagttggcact
gtcaaagtgtacctgcctaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctatgactctttggacaaggccctcaaggtgcggggtctcaatcaggactgctgtgtg
gtctacagactcatcaaaggaagaaagacagtcactgcctgggacacagccattgcacct
ctggatggcgaggagctcattgtggaggtcctggaagatgtgccactgaccatgcacaat
tttgtacggaagacattcttcagtttggccttctgtgacttctgccttaagtttctgttc
cacggctttcgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacggtctgcgttgacatgagtaccaaccgccgacagttctaccacagcatccaggat
ttgtctggaggctccaggcagcaggaggttccctcaaatctctctgtgaatgagctgcta
accccccagggtcccagtccctttacccagcaacgtgaccaggagcacttctccttccct
gcccctgccaatcccccactgcagcgcatccgctccacatctactcctaacgtccacatg
gtcagcaccacagctcccatggactccagcctcatgcagtttactgctcagagcttcagc
accgatgctgctggtagaggtggtgatggagctcctcggggtagccctagcccagctagt
gtgtcttcagggaggaagtccccacattccaagttacctgcagaacagcgggaacggaag
tccttggcagatgaaaagaaaaaagtgaagaacctggggtaccgggactcaggctattac
tgggaggtgccacccagtgaggtacagctgttgaagaggatcgggacaggctcttttggc
actgtgtttcgggggcgttggcatggcgatgtagctgtgaaagtgctcaaggtggcccaa
cctaccgctgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaagacacga
catgtcaacattttgctgtttatgggtttcatgactcggccagggtttgccatcatcaca
cagtggtgtgagggttccagcctctaccaccacctacatgtggctgacacgcgctttgac
atggtccagctcattgatgtggcccggcagactgcccagggcatggactacctccacgcc
aagaacatcattcaccgagacctaaagtccaacaatatcttcctacatgaggggctcaca
gtcaagattggtgacttcggcctggccacagtgaagacacgatggagtggggcccagccc
ttagagcagccctcagggtctgtgctgtggatggcagctgaggtgatccgaatgcaggac
ccgaacccctacagcttccagtcggatgtctatgcctatggtgttgtgctctatgagctt
atgaccggctcactgccctacagccacattggcagccgtgaccagatcatctttatggtg
ggtcgtggctatctgtctccggacctcagcaaaatcttcagtaattgccccaaagccatg
aggcgcttgctgactgactgcctcaagttccagcgggaggagcggcctctatttccccag
attctggccacgatcgagctgctgcagcggtcactccccaagattgagcggagtgcctcc
gaaccctccttgcaccgtacccaggctgatgagttgcctgcctgccttctcagcgcagcc
cgccttgtgccttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (27)   
   RefSeq(nuc) (3)   
   GenBank (12)   
   EMBL (12)   
Protein domain (10)   
   Pfam (10)   
All databases (90)   

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