KEGG   Rattus norvegicus (rat): 680308
Entry
680308            CDS       T01003                                 
Symbol
Mthfd2
Name
(RefSeq) bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
  KO
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00670  One carbon pool by folate
rno01100  Metabolic pathways
rno01240  Biosynthesis of cofactors
Module
rno_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    680308 (Mthfd2)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     680308 (Mthfd2)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     680308 (Mthfd2)
SSDB
Motif
Pfam: THF_DHG_CYH_C THF_DHG_CYH HEPN_SAV_6107 ADH_zinc_N PirA-like
Other DBs
NCBI-GeneID: 680308
NCBI-ProteinID: NP_001102868
RGD: 1311313
Ensembl: ENSRNOG00000010833
UniProt: A6IAL8
Position
4:complement(117368833..117380350)
AA seq 349 aa
MVSVSLSALAVRLLRPTHGCHSRLQSFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWV
ASGNKRPHLSVILVGDNPASHSYVLNKTRAAAEVGINSETIVKPASVSEEELLNSIRTLN
DDENVDGLLVQLPLPEHIDERKICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVW
EILKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRHTPKEQLK
KHTILADIVISAAGIPNLITADMIKEGATVIDVGINRVQDPVTAKPKLVGDVDFEGVKKK
AGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRPEELEVLKSTQRGVATN
NT seq 1050 nt   +upstreamnt  +downstreamnt
atggtttctgtttccttgtctgcgctggcagtgcggttgttgcgccccacgcacggctgc
cactcccgcctacagtccttccacctggcggcagtacgaaatgaagccgtggtcatttct
ggaaggaagctggcccagcagattaagcaagaagtacggcaggaggtggaagagtgggtg
gcctcgggcaacaagcggccacacctcagtgtcattctggttggcgacaatcctgccagt
cactcctatgttctcaacaaaaccagggcagcagctgaagtgggaatcaacagtgagaca
attgtgaaaccagcctcagtgtcagaggaagagctgttgaattcaatcaggacattgaat
gacgatgagaatgtagatggcctccttgttcagctgccactcccagagcacattgacgag
agaaagatctgcaatgctgtttctcctgacaaggatgttgatggctttcatgtcatcaac
gttgggcgcatgtgtttggaccagtattccatgctgccagcaactccatggggcgtgtgg
gagatactcaagcgaacaggcattccaaccttagggaagaatgtggtagtggctggcagg
tccaaaaacgttgggatgccaattgcaatgctgctgcacacggatggggcacacgagcgg
cctgggggtgatgccacagtcacaatatctcatcggcacactcccaaagaacagctgaag
aagcacacgatccttgcggacattgtgatatctgctgctggcattccaaacctcatcaca
gctgacatgatcaaggaaggagcaacagtcatcgacgtggggataaacagagttcaagat
cctgtcaccgcaaagcccaagttggttggagatgtggattttgaaggagtcaagaagaaa
gctggttacatcactcctgtccctgggggtgttggtcccatgacagtggccatgctcatg
aagaacaccattattgctgcaaagaaagtgctcaggccagaggagctggaagtgttgaag
tccacacagcgcggagttgccaccaactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
Protein domain (5)   
   Pfam (5)   
All databases (40)   

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