KEGG   Rattus norvegicus (rat): 682930
Entry
682930            CDS       T01003                                 
Symbol
Cacna1s
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1S
  KO
K04857  voltage-dependent calcium channel L type alpha-1S
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04024  cAMP signaling pathway
rno04260  Cardiac muscle contraction
rno04261  Adrenergic signaling in cardiomyocytes
rno04270  Vascular smooth muscle contraction
rno04723  Retrograde endocannabinoid signaling
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04727  GABAergic synapse
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04921  Oxytocin signaling pathway
rno04924  Renin secretion
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04929  GnRH secretion
rno04934  Cushing syndrome
rno04935  Growth hormone synthesis, secretion and action
rno05010  Alzheimer disease
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05207  Chemical carcinogenesis - receptor activation
rno05410  Hypertrophic cardiomyopathy
rno05412  Arrhythmogenic right ventricular cardiomyopathy
rno05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    682930 (Cacna1s)
   04020 Calcium signaling pathway
    682930 (Cacna1s)
   04024 cAMP signaling pathway
    682930 (Cacna1s)
   04022 cGMP-PKG signaling pathway
    682930 (Cacna1s)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    682930 (Cacna1s)
   04929 GnRH secretion
    682930 (Cacna1s)
   04912 GnRH signaling pathway
    682930 (Cacna1s)
   04921 Oxytocin signaling pathway
    682930 (Cacna1s)
   04935 Growth hormone synthesis, secretion and action
    682930 (Cacna1s)
   04924 Renin secretion
    682930 (Cacna1s)
   04925 Aldosterone synthesis and secretion
    682930 (Cacna1s)
   04927 Cortisol synthesis and secretion
    682930 (Cacna1s)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    682930 (Cacna1s)
   04261 Adrenergic signaling in cardiomyocytes
    682930 (Cacna1s)
   04270 Vascular smooth muscle contraction
    682930 (Cacna1s)
  09156 Nervous system
   04727 GABAergic synapse
    682930 (Cacna1s)
   04725 Cholinergic synapse
    682930 (Cacna1s)
   04726 Serotonergic synapse
    682930 (Cacna1s)
   04723 Retrograde endocannabinoid signaling
    682930 (Cacna1s)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    682930 (Cacna1s)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    682930 (Cacna1s)
   05020 Prion disease
    682930 (Cacna1s)
   05022 Pathways of neurodegeneration - multiple diseases
    682930 (Cacna1s)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    682930 (Cacna1s)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    682930 (Cacna1s)
   05414 Dilated cardiomyopathy
    682930 (Cacna1s)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    682930 (Cacna1s)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    682930 (Cacna1s)
Ion channels [BR:rno04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   682930 (Cacna1s)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel CAC1F_C
Other DBs
NCBI-GeneID: 682930
NCBI-ProteinID: NP_446325
RGD: 70983
Ensembl: ENSRNOG00000046231
UniProt: Q02485
Position
13:50045668..50115903
AA seq 1850 aa
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLQNPLRKACISVVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE
KPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLE
EDLRGYMSWITQGEVMDVDDLREGKLSLDEGGSDTESLYEIEGLNKIIQFIRHWRQWNRV
FRWKCHDLVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLALFTIEML
MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRLFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLFGGRYDFEDTEVRRSNFDNF
PQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKSEEERSTMTKKLEQKPKGEGIPTTAKL
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPASPRPRPLAELQLKEKAVPIPEASSFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILEYFDYVFT
AVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSCNDL
SKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLL
YKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHY
NQSEQMNHISDILNVAFTIIFTLEMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILS
EIDTLLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKRCDPESDYAPGEEYACGTNFAYYYFISFYMLCAFLIINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLR
TIEEEAAPEIHRAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP
VMANQRPLQFAEMEMEELESPVFLEDFPQNPGTHPLARANTNNANANVAYGNSSHRNSPV
FSSIRYERELLEEAGRPVTREGPFSQPCSVSGVNSRSHVDKLERQMSQRRMPKGQVPPSP
CQLSQEKHPVHEEGKGPRSWSTETSDSESFEERVPRNSAHKCTAPATTMLIQEALVRGGL
DSLAADANFVMATGQALADACQMEPEEVEVAATELLKRESPKGGAMPREP
NT seq 5553 nt   +upstreamnt  +downstreamnt
atggagccgtcctcaccccaggatgagggcctgaggaagaagcagcctaagaaacccgtc
cctgagattctgccgaggccaccccgggccttgttctgcttgactctccagaaccccctg
aggaaggcctgcatcagcgtcgtggagtggaaacccttcgagaccatcatcttgctcacc
atcttcgccaactgtgtggccctggcagtgtacctgcccatgccagaggatgacaacaac
actctgaaccttggcctggagaaactggagtacttcttcctcatcgtcttctccattgag
gctgctatgaagatcatagcctatggcttcctattccatcaggatgcttacctgcgcagt
ggctggaacgtgctggacttcatcattgtctttctgggtgtcttcaccgcgattctggaa
caagttaacatcattcaaaccaacacggcccccatgagcagcaaaggagccggcttggat
gtgaaggccctgcgagctttccgcgtgctcagacccctgcggctggtgtcaggggtgccc
agccttcaggtagtcctcaactccatcttcaaggccatgctccccctgttccacatcgcc
ctgctcgtcctcttcatggtcatcatctatgccatcatcgggctggagctcttcaagggc
aagatgcacaagacgtgctacttcattgggacagacatcgtggccacagtagagaatgag
aaaccatcaccctgtgctagaactggctccgggcgcccctgcaccatcaacggcagcgag
tgccgaggaggttggccaggacccaaccatggcatcacccacttcgacaactttggcttc
tctatgctcactgtgtaccagtgcatctccatggaggggtggaccgatgtcctgtactgg
gtcaatgatgccatcgggaacgagtggccctggatctactttgtcaccctcattctgctg
ggctccttcttcatcctgaacctggtgctgggtgtcctgagtggagaattcaccaaggag
cgagagaaggccaagtccagaggaaccttccaaaagctccgggagaagcagcagctggag
gaagaccttcgtggttacatgagttggatcacacagggcgaggtcatggacgtggacgac
ttgagagaaggcaagctgtctttggatgaagggggctcggatacagagagcttatatgaa
atcgagggcttgaacaaaatcatccaattcattcggcactggcggcagtggaatcgcgtc
ttccgctggaagtgccatgacctagtgaaatccaaggtcttctattggctggtgatcctg
attgtggccctcaacaccctgtccattgcctcagagcaccacaaccagccactctggctg
acgcatttgcaagatgtcgccaaccgcgtgctgctggccctcttcaccatcgagatgctc
atgaagatgtacgggctgggcctgcgccagtacttcatgtccatcttcaaccgcttcgac
tgcttcgtggtgtgcagcggcatcctggagatcttgctggtggagtcgggagccatgacg
cccctgggcatctctgtgctccgctgcatccgcctcctgaggctcttcaagatcaccaag
tactggacatcgctgagcaacctggtggcctcgctgctcaactccatccgctctatcgct
tccctcttgctgctgctctttcttttcatgatcatctttgccctgctaggcatgcagctc
tttggaggcagatacgactttgaagacacggaagtacgacgaagcaactttgacaacttc
ccccaggccctcatcagtgtcttccaggtcctgacgggtgaagactggaactctgtgatg
tacaatgggatcatggcctacggaggcccgtcctaccctggcgtgctcgtgtgcatttat
ttcatcatcctttttgtctgtggtaactacatccttctcaatgtcttcctggctatcgct
gtggacaacctggcagaggctgagagcctgacatctgcccagaaggccaaggctgaggag
agaaagcgcaggaagatgtctagagggctcccagacaagtcagaagaggagagatccaca
atgaccaagaagctggagcagaaacccaagggtgaaggcatccccaccactgccaagctg
aaaatcgatgagtttgaatcgaacgtcaatgaggtgaaagacccctacccttcagctgac
ttcccaggggacgacgaggaagatgagcctgagatcccagcaagcccccgaccacgccct
ctggctgagctgcagctgaaagagaaagcggtgcccatcccagaggccagctccttcttc
atcttcagccccaccaataagatccgcgtcctatgtcaccgcattgtcaacgccacctgg
ttcaccaactttatcctactcttcatcctgctcagtagtgctgctctggccgctgaggac
cccatccgggccgactccatgaggaatcagatccttgagtattttgattatgtgttcact
gctgttttcactgtggagatcgtccttaagatgaccacctatggagccttcctgcacaaa
ggctccttctgccgcaactacttcaacatcctggacctgctggtagtggctgtgtctctc
atctccatgggcctcgagtccagcgccatctccgtggtgaagatcttgagggtcctgagg
gtgttgcgaccactccgggccataaacagagccaaagggttgaagcacgtggtgcagtgc
gtgtttgttgctatccgcaccatcgggaacatcgtgctggtcaccacgctcctgcagttc
atgtttgcatgcatcggagtccagcttttcaagggaaaattctacagctgcaatgattta
tccaagatgactgaagaggagtgcaggggctactactacatatacaaggatggagacccc
acgcagatagagttgcgaccccgtcagtggatacacaatgacttccactttgacaatgtc
ctgtctgctatgatgtcactcttcacggtctccacctttgagggttggcctcagctactg
tacaaggccatagactccaatgaggaggacacaggccccgtctacaacaaccgagtggag
atggccatcttcttcatcatctacatcattctcatcgccttcttcatgatgaacatcttt
gtgggcttcgtcatcgtcaccttccaggagcagggggagactgagtataagaactgtgag
ctggacaagaaccagcgccaatgtgtgcagtatgccctgaaggcccgcccgctgaggtgt
tacatccccaaaaacccataccagtatcaggtgtggtatgtcgtcacttcctcctacttt
gaatacctgatgtttgctctcatcatgctcaacactatctgcctaggcatgcagcattac
aaccagtcggaacagatgaaccacatatcggacatcctcaatgtggctttcaccatcatc
ttcaccctggagatgatcctcaagctcatagctttcaagcccaggggctattttggagac
ccctggaacgtgtttgactttctaatcgtcattggcagcatcattgacgttatcctgagt
gagatcgatactttgctggcctccagcgggggactatattgcctgggtggaggctgcggg
aacgttgacccagatgagagcgcccgcatctccagtgccttcttccgcctgttccgagtc
atgcgactgatcaagctgctgagccgggcggagggtgtgcgcaccctgctctggacgttc
atcaagtccttccaggccctgccgtatgtggctttgctgatcgtcatgctcttcttcatc
tacgctgtcatcggcatgcagatgttcgggaagatcgccatggtggacgggacgcaaata
aaccggaacaacaacttccagactttcccacaagctgtgctgctgctcttcaggtgtgcc
acaggggaagcctggcaggagatcctgctggcctgcagctacgggaaacgctgcgacccg
gagtctgactacgcaccgggggaggagtacgcgtgtggcaccaactttgcctactactac
ttcatcagcttctacatgctctgcgccttcctgatcatcaacctctttgtggctgtcatc
atggacaactttgactacctcacaagggactggtccattctgggccctcaccacctggat
gagttcaaggccatctgggctgagtacgacccagaggctaagggcaggatcaagcacctg
gacgtggtgaccctgctgaggaggatccagccccctctgggctttgggaagttctgccca
cacagggtagcatgtaagaggctggtgggcatgaacatgcccctgaatagtgatggcaca
gtcaccttcaatgccacactcttcgccctggtacgcacagccctcaagatcaagacagaa
ggcaattttgaacaagccaatgaggagctgagagccatcatcaaaaagatctggaagaga
accagcatgaagctcctggaccaagtcatccctccaataggagatgacgaggtgacagtg
gggaagttctatgccacattcctcatccaggagcactttcggaagttcatgaagcgccag
gaggaatattatgggtatcgacccaaaaaggacacagttcagatacaggctggattgcgg
accatagaggaagaggcagctcctgagatccaccgagccatctctggagacctgacggcg
gaggaggagctggagagggccatggtagaggctgccatggaggaggggatattccggaga
actggaggcctgtttggtcaagtggacaacttcctggaaaggaccaactctctgccccct
gtcatggctaaccaaagacccctccaatttgccgaaatggagatggaagagctggagtca
ccagtctttttggaggacttccctcagaacccaggcacccaccctcttgctcgtgccaat
accaacaacgccaatgccaatgttgcctatggcaacagcagccatagaaacagcccagtg
ttttccagcatccgctatgaaagggagctcctggaagaggcaggcaggcctgttaccaga
gaaggacccttcagtcagccctgcagcgtctctggagttaacagcagatcccatgtggac
aaactggaaagacagatgtcccaaagaagaatgcccaaaggccaggtgcctccttcccca
tgccagctctcccaggaaaagcatcctgtgcacgaagaggggaagggccccaggtcatgg
tctacggaaacatctgacagtgagagctttgaggagcgtgttcccaggaattcggctcac
aagtgcacagccccagctaccaccatgctgatccaggaggctctggttcgaggaggacta
gactccttagcagcagatgctaacttcgtcatggcaacaggccaggccctggcagatgcc
tgccagatggaaccagaggaagtcgaggtggcagcaacagagctactgaagcgagaatcc
ccaaagggcggggccatgcccagggagccttga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (27)   
   KEGG PATHWAY (27)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
Protein domain (5)   
   Pfam (5)   
All databases (53)   

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