KEGG   Rattus norvegicus (rat): 81656
Entry
81656             CDS       T01003                                 
Symbol
Dpyd
Name
(RefSeq) dihydropyrimidine dehydrogenase [NADP(+)]
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00240  Pyrimidine metabolism
rno00410  beta-Alanine metabolism
rno00770  Pantothenate and CoA biosynthesis
rno00983  Drug metabolism - other enzymes
rno01100  Metabolic pathways
Module
rno_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    81656 (Dpyd)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    81656 (Dpyd)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    81656 (Dpyd)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    81656 (Dpyd)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     81656 (Dpyd)
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 NAD_binding_8 Pyr_redox_3 Fer4_7 Fer4_10 Dus Fer4_6 Fer4_9 Fer4_2 Fer4 FAD_oxidored Fer4_8
Other DBs
NCBI-GeneID: 81656
NCBI-ProteinID: NP_112289
RGD: 621218
Ensembl: ENSRNOG00000017105
UniProt: O89000
Position
2:209293902..210159777
AA seq 1025 aa
MAGVLSRDAPDIESILALNPRIQAHATLRSTMAKKLDKKHWKRNTDKNCFTCEKLENNFD
DIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDN
PLGLTCGMVCPTSDLCVGGCNLHATEEGPINIGGLQQFATEVFKAMNIPQIRSPLLPPPE
HMPEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSISTDEMTLSTLKENGYKAAFIGIGLPEPKKDHIFQGLTQV
QGFYTSKDFLPLVAKGSKPGMCACHSPLPSVRGAVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFANIRAVPEEMELAKEEKCEFLPFLSPRKVIVKDGKIVGMQFVRTEQDETGNWV
EDEEQIVRLKADVVISAFGSVLDDPKVIEALSPIKFNRWGLPEVNPETMQTSEPWVFAGG
DVVGMANTTVESVNDGKQASWYIHKYIQAQYGALVPSQPTLPLFYTPVDLVDISVEMAGL
RFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLY
GPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKNDWMELSKMAEAS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFAKLTPNVTDIVSI
ARAAKEGGADGVTATNTVSGLMGLKADGSPWPSVGSGKRTTYGGVSGTAIRPIALRAVTA
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELSDWDGQSPPTMSHQKGKPVPHIAELMGQKLPSFGPYLERRKKILAASKIREKDQ
NRACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGELNVMEQVVALIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYEPKRGLPLA
VKPVC
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggcgggtgtgctgagcagggacgcgcctgacatcgagagtatcctggctttaaatcct
cgaatacaagctcatgcgactcttcgttccaccatggccaagaaactagacaagaaacat
tggaaaaggaacactgataagaactgctttacctgtgagaagctggagaataattttgat
gacatcaagcacacgactcttggtgagcgaggggctctccgagaagcagtgagatgcttg
aaatgtgcagatgctccctgccagaagagttgtcccacgtctcttgacattaagtcattc
atcacaagtatcgccaacaagaactactatggtgcagctaagctgattttttccgataat
cctcttggtcttacttgcggaatggtttgtccaacatctgacctctgtgtcggaggatgc
aacttacatgctactgaagaggggccaattaatattggtggactgcagcagtttgctacc
gaggtgttcaaagcgatgaacatcccacagatcagaagcccgttgctgcctcctccggaa
catatgccggaagcttactcagcaaaaattgcgctgtttggagctgggcctgcgagtata
agctgtgcctcctttctggctcgactgggctattccgacatcaccatatttgaaaagcaa
gaatacgttggtggcttaagcacttctgaaatccctcagtttcggctcccatatgatgtc
gtgaattttgagattgagctcatgaaggaccttggtgtcaagataatttgtggtaaaagc
atttccacagatgaaatgactcttagtactttgaaagaaaatggctacaaagctgctttt
attggaataggtttgccagaacccaaaaaggaccatattttccaaggcttgacacaagtc
cagggattttacacatccaaagactttttgccacttgtcgccaaaggtagcaaaccagga
atgtgcgcctgtcactctccattgccatccgtgaggggagccgtgattgtactcggagct
ggggacactgcgtttgactgtgcaacatccgctctgcgctgcggagcacgtcgcgtgttc
atcgtcttcagaaagggctttgctaatattcgagctgttccagaggagatggagcttgct
aaggaagagaaatgtgaatttttgcctttcctttccccacggaaggttatagtcaaagat
ggaaagattgtaggaatgcagtttgttcgaactgagcaggatgaaaccggaaactgggtc
gaagatgaagagcagatagtgcgtttgaaggctgatgtggttattagcgcctttggatct
gtcttggatgatcccaaagtgatagaagcattgagtcccatcaagtttaacagatggggt
ctccctgaagtaaacccagaaaccatgcaaaccagtgagccatgggtatttgcaggtggt
gatgttgtgggtatggctaacaccacagtggaatctgtcaatgatggaaaacaggcttca
tggtacattcacaagtacatacaggcacaatatggagccttggtgccttcccagcctaca
ctgcccctgttttacactcctgttgacctcgtggacatcagtgtggaaatggcagggttg
aggttccccaatccctttggccttgccagtgcgacaccagccactagcacaccaatgatt
cgaagggcctttgaagcaggatggggttttgctttgaccaaaactttctctcttgataag
gacatcgtgacaaacgtctcacccagaatcatccgagggaccacttctggccccttgtat
ggccctggacaaagctctttcctcaacattgagctcatcagtgagaaaacagctgcatat
tggtgtcacagtgtcaccgaactaaaggctgacttcccggacaacatcctgatcgccagc
atcatgtgcagttacaacaaaaatgactggatggaactctccaaaatggctgaggcttct
ggagcagatgccctggagttaaatttatcctgtccacatggcatgggggagagaggaatg
ggtttggcttgtgggcaggatccagagctggtgaggaacatctgtcgctgggtgagacaa
tctgttcgggttccattttttgccaagttgaccccaaatgtcactgatattgtaagcatc
gcaagagcagcaaaggaaggtggtgcagatggcgttacagccaccaacactgtctcaggc
ctgatgggactgaaagctgatggttcaccctggccttcggtgggcagtggaaagaggact
acatatggaggagtatcaggaactgccatcaggcctattgctttgagagctgtgaccgcc
attgcccgcgctttgcctgggtttcctatactggccacaggtggaattgactcagctgaa
agtggacttcagtttcttcatagtggtgcttcagttctccaggtatgcagtgctattcag
aatcaggacttcactgtgattgaagattactgcactggcctcaaagctctgctttatctg
aagagtattgaagagttatcagactgggatgggcagagtccacccactatgagtcatcag
aaagggaaaccagttccacacattgctgagctcatgggacagaaacttccaagctttgga
ccgtaccttgaacggcgcaagaaaatcctagcagcaagtaaaatcagagagaaagatcaa
aacagagcttgctcacctctccagagaaagcactttaactcccaaaagccgattcctgcc
atcaaggatgtaattggaaaatcactgcaatacctggggacgtttggtgagctgaacgtc
atggagcaagttgtggccctgatcgatgaggaaatgtgtatcaattgcggcaaatgttac
atgacctgtaatgactctggctaccaggctatacagttcgatccagaaactcacctgcct
actgttagcgacacatgtacaggctgcactctctgcctcagcgtctgccctattatggac
tgtatcaggatggtttccagggcaacaccttatgaaccaaagagaggcctaccattagcc
gtgaagccggtgtgttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (7)   
   RefSeq(nuc) (5)   
   GenBank (1)   
   EMBL (1)   
Protein domain (15)   
   Pfam (15)   
All databases (56)   

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