KEGG   Rattus norvegicus (rat): 81743
Entry
81743             CDS       T01003                                 
Symbol
Pde2a
Name
(RefSeq) cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
  KO
K18283  cGMP-dependent 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00230  Purine metabolism
rno01100  Metabolic pathways
rno04022  cGMP-PKG signaling pathway
rno04740  Olfactory transduction
rno04925  Aldosterone synthesis and secretion
rno05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    81743 (Pde2a)
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    81743 (Pde2a)
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    81743 (Pde2a)
  09157 Sensory system
   04740 Olfactory transduction
    81743 (Pde2a)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    81743 (Pde2a)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.17  3',5'-cyclic-nucleotide phosphodiesterase
     81743 (Pde2a)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2 GAF_3
Other DBs
NCBI-GeneID: 81743
NCBI-ProteinID: NP_112341
RGD: 620965
Ensembl: ENSRNOG00000019560
UniProt: Q01062 A6I6U9
Position
1:165235623..165327466
AA seq 928 aa
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAGLRQAAKD
ALSAVLPKVETVYTYLVDGESRLVCEDPPHELPQEGKIREAVISRKRLSCDGLGPSDLLG
KPLARLVAPLAPDTQVLVIPLLDKETGTVAAVILVHCGQLSDSEEQSLQVVEKHALVALQ
RVQALQQRRPEAVQNTSADPSEDQKDEKGYTAHDRKILQLCGELYDLDATSLQLKVLRYL
QQETQATHCCLLLVSEDNLQLSCKVIGEKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLT
SDDVQQLQNMLGCELRAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDERAIQHCFHY
TGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSV
FLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVD
DSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSL
LYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPE
DDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY
KNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA
QAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNN
KQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREK
AYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNS
LDFLDEEYEVPDLDVTRAPVNGCCSLEG
NT seq 2787 nt   +upstreamnt  +downstreamnt
atggtcctggtgttgcaccacatcctcatcgctgttgtccaattcctcaggcggggccag
caggtcttcctcaagccggacgaaccgccgccgcagccatgcgccgacagcctgcaggat
gctttgctgagcctgggcgccgttatcgacatcgcgggccttcgacaggctgccaaggat
gccctctcggccgtgctccccaaagtggagactgtctacacctacctggtagatggggag
tccaggctggtgtgtgaggacccccctcatgagctgccacaggaaggaaaaattcgagag
gctgtgatttctcggaagcggctgagctgcgatgggctgggaccttcagacctactagga
aagcccttggccaggctggtggctccactggcccctgacacgcaagtgctggtcataccc
ctgctggacaaggagactggaactgtggcagccgtcatcttggtgcactgtggccagctg
agtgacagtgaggagcagagcctgcaggtggtggagaagcatgctctggtggccctgcag
agggtgcaggccctgcagcagcgcaggcctgaagctgttcagaacacctcagcggatccc
tctgaagatcaaaaggatgagaagggatacaccgcccatgaccgaaagatcctgcaactg
tgtggagaactctatgacttggatgccacttctctgcagctcaaagtccttcgatatctt
cagcaggagacacaggccactcactgctgcctcctgctggtgtcagaggacaacctgcag
ctttcctgcaaggtcattggagagaaagtgctgggagaagaggtcagctttccattgacc
atgggacgcctgggccaggtggtggaggacaaacagtgtatccagttgaaggacctaacc
tctgacgatgtgcaacagctacaaaacatgttgggctgtgagcttcgggctatgctatgt
gtccctgtcatcagtcgagccactgaccaggtggtggccctggcttgcgccttcaacaag
cttggaggagacttcttcacagatgaggatgaacgtgcgatccaacactgcttccactac
acaggcacggtgctcaccagtaccttggccttccagaaggagcagaagctcaagtgtgag
tgccaggctcttctccaagtggcaaagaacctcttcacccacctggatgacgtctctgtc
ctgctacaggagatcatcacagaggccagaaacctcagcaacgcagagatctgctccgtg
ttcctgctggatcagaatgagctggttgccaaggtgttcgatggcggagtagtggacgat
gagagttatgagatccgcatccctgcggaccaaggcatcgcgggccacgtggcgaccacg
ggccagatcctgaacatcccagatgcatacgcccatccgcttttctatcgcggcgtagac
gacagcactggcttccgcacgcgcaacattctctgcttccctatcaagaacgagaaccaa
gaggtcatcggtgtggctgagctagtgaacaagatcaatgggccatggttcagcaaattt
gatgaggacctggccacagccttctccatctactgtggcattagcatcgctcactctctc
ctatacaaaaaggtgaatgaagcccagtaccgcagccacctggccaacgagatgatgatg
taccatatgaaggtctctgacgatgaatacaccaaacttctccatgatggcatccaacct
gtggccgccattgactccaactttgccaacttcacctatactcctcggtctctgcctgag
gacgatacttctatggccatcctgagcatgctgcaagacatgaacttcatcaataactac
aaaattgactgcccaactctggcccggttctgcctgatggtgaagaaaggctaccgggat
ccgccctaccacaactggatgcacgccttctctgtctctcacttttgctacttgctctac
aagaatctggagctctccaactacctcgaggacatcgagatctttgcgttgtttatttcc
tgcatgtgtcacgacctggaccacagaggcacaaacaactccttccaggtggcctcgaaa
tctgtgctggctgcactctacagctcagagggctctgtcatggagaggcaccactttgct
caggccattgctatcctcaacacccatggctgtaatatctttgaccacttctctcggaag
gactatcagcgaatgctggacctgatgagggacatcatcttggccacggacctggcacac
cacctccgcatcttcaaggacctgcagaagatggctgaagtgggttatgaccgaaacaac
aagcaacaccacaggcttcttctatgcctccttatgacctcctgtgacctctctgaccag
acaaagggctggaagaccaccagaaagattgcggagctgatctacaaagagttcttctcc
caaggagacttggagaaggccatgggcaaccgaccaatggagatgatggatcgggagaag
gcctacatccctgaacttcagatcagctttatggagcacatcgccatgcccatctacaag
ctgttacaagacctgttccccaaggcagcagagctgtatgaacgcgtggcctccaatcgt
gagcactggaccaaggtgtcccacaagttcaccatccgaggcctccccagtaacaactcg
ctggatttcctggatgaggaatatgaggtccctgatttggacgtcaccagggctcctgtc
aatggctgctgcagcctcgagggctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (10)   
   RefSeq(nuc) (4)   
   GenBank (3)   
   EMBL (3)   
Protein domain (4)   
   Pfam (4)   
All databases (43)   

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