KEGG   Rattus norvegicus (rat): 84021
Entry
84021             CDS       T01003                                 
Symbol
Irs3
Name
(RefSeq) insulin receptor substrate 3
  KO
K17445  insulin receptor substrate 3
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04022  cGMP-PKG signaling pathway
rno04068  FoxO signaling pathway
rno04140  Autophagy - animal
rno04152  AMPK signaling pathway
rno04211  Longevity regulating pathway
rno04213  Longevity regulating pathway - multiple species
rno04910  Insulin signaling pathway
rno04920  Adipocytokine signaling pathway
rno04923  Regulation of lipolysis in adipocytes
rno04930  Type II diabetes mellitus
rno04935  Growth hormone synthesis, secretion and action
rno05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    84021 (Irs3)
   04022 cGMP-PKG signaling pathway
    84021 (Irs3)
   04152 AMPK signaling pathway
    84021 (Irs3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    84021 (Irs3)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    84021 (Irs3)
   04923 Regulation of lipolysis in adipocytes
    84021 (Irs3)
   04920 Adipocytokine signaling pathway
    84021 (Irs3)
   04935 Growth hormone synthesis, secretion and action
    84021 (Irs3)
  09149 Aging
   04211 Longevity regulating pathway
    84021 (Irs3)
   04213 Longevity regulating pathway - multiple species
    84021 (Irs3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    84021 (Irs3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    84021 (Irs3)
SSDB
Motif
Pfam: IRS PH
Other DBs
NCBI-GeneID: 84021
NCBI-ProteinID: NP_114463
RGD: 69317
Ensembl: ENSRNOG00000001389
UniProt: O08724
Position
12:24689930..24692068
AA seq 494 aa
MKPAGTGPTVSSGGESTDVSLGPPFPWPCPPDVRLCGHLRKQKSQRRRFFVLRADPPRLE
CYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLIVIYTSDSSLGVAAASEAE
QQTWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQDVWPVTLRSKGLGRAPGLSS
GSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSLLSVRRCGHADSFFFLELGRSAP
IGPGELWLQAPDAVVAQSIHETVLAAMKRLGSSAASGKAEAPLGDSPKGASAVPAPAPYE
IPALALAAQARSPGERAKQDYVNPLERMGSAPSYRGPDLGGDYIAMGMRNDYVHMGGKAA
EYMWMAPPGLPPPTPPRVDPRKEPEDCESTEYMPMNRFLPGPLYYEFKAREPEHGHSSAQ
CSIRDRWRPMVAQPRSSQGSELSGDYMYIPDYPSARLGSLDSCLNYVDLDLVPPLEVPGA
APGNSPHSYASIKF
NT seq 1485 nt   +upstreamnt  +downstreamnt
atgaagcctgcaggtacgggccccacagtctcctctgggggcgagtccaccgacgtgtcc
ctcggcccgccgtttccttggccctgcccgcccgacgtgcggctctgtggccatctgagg
aagcagaagtcccagcgccgccgctttttcgtgctgcgtgctgacccaccacggctggag
tgctatgagagcgagaagaagttcttggccagcggctgccgcccacctcgaccccggcgt
accgttagcctggaaggtgcctgcactattagcaagcgcgcggatgcccgtcagcgccac
ctgatcgtcatctataccagcgacagcagcctgggcgtggcggcggccagtgaagcagag
cagcaaacatggtacagcgccttgctcgaggtgcgcgccaccgccgctgcagctgctgcc
accgctatgggtttcagcccccaagaggcccctgagtcttggatcttcgccccgttccag
gacgtctggcctgtgacactgcggtccaaggggctggggagagcaccaggcctgagcagc
ggcagctatcgcctgtgcctgggttctggggccctgagcctcctgcggaagccgggaagc
aaaggctccagagacagccgggcaacgccaccaccagtcctgcgcttgtccttgcttagt
gtgcgccgctgcggccacgcagattcctttttcttcctggaactcgggcgctcagcgccc
ataggtcctggtgagctgtggctgcaggcccctgatgcagtggtggcccaaagcattcat
gagaccgtcctggctgccatgaagagactggggagcagtgcagccagtggcaaagctgag
gcaccgctgggagattctccaaagggggcttctgcagtccctgccccagcaccatatgag
atccctgctttggcactggcagcacaagcgagaagtccgggtgagagagcgaagcaggac
tacgtcaatccactggaaaggatggggtcagcaccctcctacagggggccagatctgggt
ggggactacatcgccatgggaatgaggaatgactatgtgcacatgggggggaaagctgct
gagtacatgtggatggcgcccccaggtctccctccccccacccctcccagggtagatccc
agaaaggagcctgaggattgtgagagcacagagtatatgcccatgaacagatttttaccg
gggcctctttactacgagttcaaggccagggagcctgaacatgggcattctagtgcccag
tgtagcattagggacagatggagacccatggtggctcagccccgctcttcccaagggtca
gagctctctggggactacatgtacatccctgactatcccagtgctaggctggggtctctg
gacagctgcctcaactatgtggacctggacctagtccctcccctggaggttcctggagcg
gccccagggaatagtccacatagctatgccagcatcaagttctag

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (12)   
   KEGG PATHWAY (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (2)   
   Pfam (2)   
All databases (29)   

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