Entry |
|
Symbol |
Plcb2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
|
KO |
|
Organism |
rno Rattus norvegicus (rat)
|
Pathway |
rno04070 | Phosphatidylinositol signaling system |
rno04072 | Phospholipase D signaling pathway |
rno04261 | Adrenergic signaling in cardiomyocytes |
rno04270 | Vascular smooth muscle contraction |
rno04613 | Neutrophil extracellular trap formation |
rno04621 | NOD-like receptor signaling pathway |
rno04723 | Retrograde endocannabinoid signaling |
rno04750 | Inflammatory mediator regulation of TRP channels |
rno04919 | Thyroid hormone signaling pathway |
rno04925 | Aldosterone synthesis and secretion |
rno04927 | Cortisol synthesis and secretion |
rno04928 | Parathyroid hormone synthesis, secretion and action |
rno04933 | AGE-RAGE signaling pathway in diabetic complications |
rno04935 | Growth hormone synthesis, secretion and action |
rno04961 | Endocrine and other factor-regulated calcium reabsorption |
rno04973 | Carbohydrate digestion and absorption |
rno05022 | Pathways of neurodegeneration - multiple diseases |
rno05163 | Human cytomegalovirus infection |
|
Module |
rno_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:rno00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
85240 (Plcb2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
85240 (Plcb2)
04310 Wnt signaling pathway
85240 (Plcb2)
04371 Apelin signaling pathway
85240 (Plcb2)
04020 Calcium signaling pathway
85240 (Plcb2)
04070 Phosphatidylinositol signaling system
85240 (Plcb2)
04072 Phospholipase D signaling pathway
85240 (Plcb2)
04071 Sphingolipid signaling pathway
85240 (Plcb2)
04022 cGMP-PKG signaling pathway
85240 (Plcb2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
85240 (Plcb2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
85240 (Plcb2)
04613 Neutrophil extracellular trap formation
85240 (Plcb2)
04621 NOD-like receptor signaling pathway
85240 (Plcb2)
04062 Chemokine signaling pathway
85240 (Plcb2)
09152 Endocrine system
04911 Insulin secretion
85240 (Plcb2)
04922 Glucagon signaling pathway
85240 (Plcb2)
04929 GnRH secretion
85240 (Plcb2)
04912 GnRH signaling pathway
85240 (Plcb2)
04915 Estrogen signaling pathway
85240 (Plcb2)
04921 Oxytocin signaling pathway
85240 (Plcb2)
04926 Relaxin signaling pathway
85240 (Plcb2)
04935 Growth hormone synthesis, secretion and action
85240 (Plcb2)
04918 Thyroid hormone synthesis
85240 (Plcb2)
04919 Thyroid hormone signaling pathway
85240 (Plcb2)
04928 Parathyroid hormone synthesis, secretion and action
85240 (Plcb2)
04916 Melanogenesis
85240 (Plcb2)
04924 Renin secretion
85240 (Plcb2)
04925 Aldosterone synthesis and secretion
85240 (Plcb2)
04927 Cortisol synthesis and secretion
85240 (Plcb2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
85240 (Plcb2)
04270 Vascular smooth muscle contraction
85240 (Plcb2)
09154 Digestive system
04970 Salivary secretion
85240 (Plcb2)
04971 Gastric acid secretion
85240 (Plcb2)
04972 Pancreatic secretion
85240 (Plcb2)
04973 Carbohydrate digestion and absorption
85240 (Plcb2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
85240 (Plcb2)
09156 Nervous system
04724 Glutamatergic synapse
85240 (Plcb2)
04725 Cholinergic synapse
85240 (Plcb2)
04728 Dopaminergic synapse
85240 (Plcb2)
04726 Serotonergic synapse
85240 (Plcb2)
04720 Long-term potentiation
85240 (Plcb2)
04730 Long-term depression
85240 (Plcb2)
04723 Retrograde endocannabinoid signaling
85240 (Plcb2)
09157 Sensory system
04742 Taste transduction
85240 (Plcb2)
04750 Inflammatory mediator regulation of TRP channels
85240 (Plcb2)
09159 Environmental adaptation
04713 Circadian entrainment
85240 (Plcb2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
85240 (Plcb2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
85240 (Plcb2)
09174 Infectious disease: parasitic
05146 Amoebiasis
85240 (Plcb2)
05142 Chagas disease
85240 (Plcb2)
05143 African trypanosomiasis
85240 (Plcb2)
09164 Neurodegenerative disease
05010 Alzheimer disease
85240 (Plcb2)
05016 Huntington disease
85240 (Plcb2)
05017 Spinocerebellar ataxia
85240 (Plcb2)
05022 Pathways of neurodegeneration - multiple diseases
85240 (Plcb2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
85240 (Plcb2)
05415 Diabetic cardiomyopathy
85240 (Plcb2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
85240 (Plcb2)
04934 Cushing syndrome
85240 (Plcb2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:rno04131]
85240 (Plcb2)
Enzymes [BR:rno01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
85240 (Plcb2)
Membrane trafficking [BR:rno04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
85240 (Plcb2)
Endocytosis
Macropinocytosis
Phospholipase C
85240 (Plcb2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Position |
3:complement(126134925..126158303)
|
AA seq |
1183 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKE
NVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGV
SEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTA
GLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYN
KRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLL
KHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKR
RYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSG
YHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEV
TGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKG
VVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPC
EETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAR
EKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQE
VVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESM
RACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL |
NT seq |
3552 nt +upstreamnt +downstreamnt
atgtctttgctcaaccctgtcctgttgccccctaaggtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacctcaatagcctcccctgttatccttcgggtg
gatcccaagggctattacttatactggacacatcaaagtaaggagatggaatttctggat
gtcacgagcatccgagacactcgctttgggaagtttgccaagatacccaagagccagaaa
ctccgggaggtattcaacatggactttccagacaaccacttcctgctgaaaacattcaca
gtggtatccggcccggacatggtgggcctcaccttccacaattttgtctcttacaaggag
aacgtaggcaaggattgggctgaggatgtactggctctggccaaacacccaatgacagcc
aatgcttctcgaagcacattcctagacaagatcctggtgaagcttaaaatgcagctgagc
cctgaagggaagatccctgtgaagaattttttccagatgtttcctgccgatcgcaaacgt
gtagaagctgccctcagtgcctgtcaccttgcaaaaggcaagaatgatgctatcaatccc
gaggacttcccagaatctgtgtacaagagcttcctcatgagcctctgtcctcggccagaa
attgatgagatcttcacttcttatcatgctaaagccaaaccctacatgaccaaggagcac
ctgaccaaattcatcaatcagaagcaacgagaccctcgactcaattccttgctgttccca
ccagcccggcctgagcaggtgcaggcgctcattgacaagtacgagcccagcggcatcaat
gtgcagaggggccaactgtcaccagagggcatggtctggtttctctgtggaccagagaac
agtgtcctggcccatgatactctgcggatccaccaagacatgacacagcctctgaatcac
tacttcatcaactcctcacacaacacctacctgacagctggccagttttcaggcccttcc
tcggctgagatgtaccgccaggtgctgctatctggctgccgttgtgtagaattagattgt
tggaaaggaaagccccccgacgaagaacccatcatcacccacggcttcactatgaccaca
gatatcttgttcaaggaagcagtcgaagccattgcagaaagtgcctttaagacctcccca
tatcctgtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggctaagatg
gccgagtactgccggaccatgtttggagagaccttgctcacagagcccctggaaaacttt
cctctgaaacctggcatgcctctgcctagccctgaggacctccggggcaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcccccaacaagaagcctgatggggtg
tctgagggcggcttcccatctagtgtccctgtagaagaggacacggggtggactgctgag
gaccggactgaggtggaggagggagaggaggaggaggaggtggaagaagaggaagaggag
gagtcaggaaacctggatgaagaagaaattaagaagatgcagtctgatgagggcacagca
ggcttggaggtgacagcttatgaggaaatgtccagccttgtcaattacatccagcccacc
aagtttatctccttcgagttctctgcacagaagaacaggagttaccttgtctcttccttc
acggagctcaaggcctacgagctgctctccaaggcctccatgcagtttgtggactataat
aaacgccagatgagccgcgtgtaccccaagggcacgcgcatggactcttccaactacatg
ccccagatgttctggaatgccggatgtcagatggttgccctcaatttccagacaatggat
ctgcccatgcagcagaacatggcactgtttgagttcaacgggcagagtggctacctccta
aagcacgagttcatgcgcaggcaggacaagcagttcaaccccttctcggtggaccgcatt
gatgtggtggttgccactaccctttccattacggtcatctctgggcagttcctgtcagag
cgcagtgtgcgcacctatgtggaagtagaactgtttggcctcccaggggaccccaagagg
cgctatcgtaccaagctgtcacctactgctaactccatcaatcctgtctggaaggaggaa
cccttcatttttgagaagatcttggtgcctgagctggcctccctcaggatagctgtaatg
gaagaaggcggcaaatttattggacatcgcatcatccccatcaatgccttacattccgga
taccaccatctgtgcctgcgcagtgagagcaacatgcctctcaccatgcctgctctcttc
gtcttcctggagatgaaggactatgtacctgacacgtgggcagatcttactgtggctctt
gccaaccccatcaagtacttcagtgcccatgataagaagtctgtgaagctcaaagaagtg
acaggaagtctgcctgagaagctcttctctgggattcctgttgccagccagtccaacggg
gctccagtctccgcaggcaatgggtcaacagcgcctgggaccaaggccaaggaggaagct
acgaaggaagtggcagagccacagaccactagcttggaagagctgcgggagctgaagggc
gtggtgaagctgcagcggagacatgagaaggagcttcgagagctggagcggcgtggagcc
cggcgctgggaggagctgctgcagcgtggcgctgcacagctagcggagctccaggaccca
gcagcaagctgcaagctccgcccgggcaagggctcccgcaagaagaggatcgtgccctgt
gaggagaccatcgtggtgcctagggaggtcctcgagggaccggacccccgcgtgcaggat
ctgaaggacaggctggagcaggagctgcagcagcaaggcgaggagcagtaccgctctgtc
ctcaagcgtaaggagcagcacgtgaccgagcaaatcgccaagatgatggagctggccaga
gagaaacaggctgctgaactcaagagcttcaaggagacctcggaaactgacaccaaagag
atgaagaaaaaactggaggccaaaaggctggagcggatccaagccatgaccaaagtcacc
acagacaaggtggcccaggagaggctcaagagagaaattaacaactcccacatccaggag
gtggtgcaggctgtcaagcagatgacagagaccctggagcgtcaccaggagaagctggaa
gagaagcagacagcctgcctggagcagatccaggcaatggaaaagcagttccaggagaag
gcgctggcagagtatgaggccaagatgaagggcctggaggctgaagtaaaggagtcaatg
cgggcttgcttcaaggcctgcttccccacggaagcagaagagaagcctgagaggccctgt
gaggcctctgaggagtcgtgtccacaggagccacttgtgaacaagacagacactcaggag
agccgcctctga |