KEGG   Sus scrofa (pig): 100233188
Entry
100233188         CDS       T01009                                 
Symbol
LCK
Name
(RefSeq) tyrosine-protein kinase Lck
  KO
K05856  lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc04064  NF-kappa B signaling pathway
ssc04380  Osteoclast differentiation
ssc04650  Natural killer cell mediated cytotoxicity
ssc04658  Th1 and Th2 cell differentiation
ssc04659  Th17 cell differentiation
ssc04660  T cell receptor signaling pathway
ssc05135  Yersinia infection
ssc05166  Human T-cell leukemia virus 1 infection
ssc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ssc05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    100233188 (LCK)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100233188 (LCK)
   04660 T cell receptor signaling pathway
    100233188 (LCK)
   04658 Th1 and Th2 cell differentiation
    100233188 (LCK)
   04659 Th17 cell differentiation
    100233188 (LCK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100233188 (LCK)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100233188 (LCK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100233188 (LCK)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100233188 (LCK)
  09163 Immune disease
   05340 Primary immunodeficiency
    100233188 (LCK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssc01001]
    100233188 (LCK)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ssc03036]
    100233188 (LCK)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100233188 (LCK)
Protein kinases [BR:ssc01001]
 Non-receptor tyrosine kinases
  SRC family
   100233188 (LCK)
Chromosome and associated proteins [BR:ssc03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    100233188 (LCK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_2 SH3_9 ABC1 Haspin_kinase Kdo SH3_16 SH3_3
Other DBs
NCBI-GeneID: 100233188
NCBI-ProteinID: NP_001137185
Ensembl: ENSSSCG00000003608
UniProt: B8XSK4
Position
6:88719886..88745922
AA seq 509 aa
MGCSCSSNPEDDWMENIDVCENCRYPIVPLDGKATLPMRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQNGEWWKAQSLTTGLEGFIPFNFVAKAN
SLEPEPWFFKNLSRRDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVMKH
YKIRNLDKGGFYISPRITFPGLHELVHHYTNSSDGLCTRLNRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTSTGIKLTINKLLDMAAQIAEGMAFIEDRNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNTEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER
PEERPTFDYMRSVLEDFFTATEGQYQPQP
NT seq 1530 nt   +upstreamnt  +downstreamnt
atgggctgtagctgcagctcaaaccctgaagatgactggatggaaaacatcgacgtatgt
gagaactgccgttaccccatagtcccactggatggcaaggccacgctgcccatgcggaat
ggctctgaagttcgggatccactggtcacctatgagggctccaaccccccagcctctcca
ctgcaagacaacctggtgatcgccctgcacagctatgagccttctcacgatggagacctg
ggcttcgagaagggtgaacagctacgtatattagagcagaacggcgagtggtggaaagca
cagtccctgaccacgggcctggaaggtttcatccctttcaacttcgtggccaaagcaaac
agccttgagccggaaccctggttcttcaagaatctgagccgcagggatgcggagaggcag
cttttggcgccggggaacacgcacggctccttcctgatccgggagagcgagagcacagcg
ggatccttttcattgtccgtccgggacttcgaccagaaccaaggagaagtgatgaaacat
tacaagatccgtaacctggacaaaggcggcttctacatctctccccgcatcacttttcct
ggcttgcacgaactggtccatcattacacgaattcttcggacgggttgtgcacgcgattg
aaccggccctgccagacccagaagccccagaagccttggtgggaggacgagtgggaagtt
cccagggagacgctgaagctggtggagcggctgggggctggccagttcggggaggtgtgg
atggggtactacaacgggcacacgaaggtggcagtaaagagcctgaagcagggcagcatg
tcccccgatgccttcctggccgaggccaacctcatgaagcagctgcaacaccagcgactg
gtccggctctatgcggtagtcacccaggagcccatctacatcatcacggaatacatggag
aatgggagcctggtggatttcctcaagacctccacaggcatcaaactgaccatcaacaaa
ctcttggacatggcagcccaaattgcagagggcatggcattcattgaagatcggaattac
atccaccgtgacttgagggctgccaatatcctggtgtctgataccctgagctgcaagatc
gcagactttggcctagcgcgcctcattgaggacaacgagtacacagccagggagggggcc
aagttccccattaagtggacagcaccagaagccatcaactacgggacattcaccatcaag
tctgatgtgtggtctttcgggatcctgctgacagagattgtcactcacggtcgcatcccg
tacccaggaatgaccaatactgaggtgattcagaacctggagcgaggctaccgcatggta
cgacctgacaactgcccagaggagttgtaccacctcatgatgctgtgctggaaggagcgc
ccggaggaacggcccacttttgactacatgcgcagcgtgctggaggacttcttcacggcc
acggagggccagtaccagccccagccatga

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