KEGG   Sus scrofa (pig): 100294678
Entry
100294678         CDS       T01009                                 
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00010  Glycolysis / Gluconeogenesis
ssc00020  Citrate cycle (TCA cycle)
ssc00620  Pyruvate metabolism
ssc00785  Lipoic acid metabolism
ssc01100  Metabolic pathways
ssc01200  Carbon metabolism
ssc01210  2-Oxocarboxylic acid metabolism
ssc04066  HIF-1 signaling pathway
ssc04922  Glucagon signaling pathway
ssc05230  Central carbon metabolism in cancer
ssc05415  Diabetic cardiomyopathy
Module
ssc_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    100294678 (PDHA1)
   00020 Citrate cycle (TCA cycle)
    100294678 (PDHA1)
   00620 Pyruvate metabolism
    100294678 (PDHA1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    100294678 (PDHA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    100294678 (PDHA1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    100294678 (PDHA1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    100294678 (PDHA1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    100294678 (PDHA1)
Enzymes [BR:ssc01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     100294678 (PDHA1)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Other DBs
NCBI-GeneID: 100294678
NCBI-ProteinID: XP_003360292
Ensembl: ENSSSCG00000023643
Vega: OTTSUSG00000004407
UniProt: A0A4X1V4S1 A0A480VQH5
Position
X:15699924..15718908
AA seq 390 aa
MRKMLAAVSRVLSGVAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRRGGCGKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCVFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYCNDPPFEVRGANQWIKFKSIS
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgaggaagatgctcgccgccgtctcccgcgtgttgtcgggcgtcgcccagaagccggca
agcagagtgctggtggcgtcccgtaactttgcaaatgatgctacatttgaaattaagaaa
tgtgatcttcaccggctggaagagggcccacctgtcaccacggtgctcaccagggaggat
gggctcaagtactacaggatgatgcagactgttcgccgaatggagttaaaagcagatcag
ctctataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgt
tgcgtgggcctggaggctggcataaaccctacggaccatctgatcacagcctaccgagct
catggctttacctttactcgtgggctttctgtccgggaaattcttgcggaacttacagga
cgaagaggaggttgtggtaaaggaaaaggaggatcgatgcatatgtatgccaagaacttc
tacgggggcaatggcattgtgggagctcaggtgcccctgggagctgggattgctctggcc
tgtaagtataatggaaaagatgaggtctgtttgactttgtatggagatggtgctgctaat
cagggtcagatatttgaagcttacaacatggcagctttgtggaaattgccttgtgttttc
atctgtgagaataatcgctatgggatgggaacgtctgtggagagagccgcagccagcact
gactactataagagaggcgacttcattcctgggctgagggtagatggaatggatatcctg
tgtgtccgggaggccacaaggtttgcagctgcctactgtagatctggaaaggggcccata
ctgatggagctgcagacttaccgttaccatggacacagtatgagtgatcccggagtcagt
taccgtacacgagaagaaattcaggaagtaagaagtaagagtgacccgatcatgcttctc
aaggatagaatggtgaacagcaatcttgccagtgttgaagaattaaaggaaatcgatgtt
gaagtgaggaaagaaattgaggatgctgcacagtttgctactgctgatcctgaaccacct
ttggaagaactcggctatcacatctactgcaacgacccgccttttgaagtccggggtgca
aaccagtggatcaagtttaagtccatcagttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (11)   
   KEGG MODULE (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
Protein domain (3)   
   Pfam (3)   
All databases (57)   

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