KEGG   Sus scrofa (pig): 100512686
Entry
100512686         CDS       T01009                                 
Symbol
IRS1
Name
(RefSeq) insulin receptor substrate 1
  KO
K16172  insulin receptor substrate 1
Organism
ssc  Sus scrofa (pig)
Pathway
ssc04022  cGMP-PKG signaling pathway
ssc04068  FoxO signaling pathway
ssc04140  Autophagy - animal
ssc04150  mTOR signaling pathway
ssc04151  PI3K-Akt signaling pathway
ssc04152  AMPK signaling pathway
ssc04211  Longevity regulating pathway
ssc04213  Longevity regulating pathway - multiple species
ssc04722  Neurotrophin signaling pathway
ssc04910  Insulin signaling pathway
ssc04920  Adipocytokine signaling pathway
ssc04923  Regulation of lipolysis in adipocytes
ssc04930  Type II diabetes mellitus
ssc04931  Insulin resistance
ssc04932  Non-alcoholic fatty liver disease
ssc04935  Growth hormone synthesis, secretion and action
ssc04960  Aldosterone-regulated sodium reabsorption
ssc05010  Alzheimer disease
ssc05206  MicroRNAs in cancer
ssc05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100512686 (IRS1)
   04022 cGMP-PKG signaling pathway
    100512686 (IRS1)
   04151 PI3K-Akt signaling pathway
    100512686 (IRS1)
   04152 AMPK signaling pathway
    100512686 (IRS1)
   04150 mTOR signaling pathway
    100512686 (IRS1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100512686 (IRS1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100512686 (IRS1)
   04923 Regulation of lipolysis in adipocytes
    100512686 (IRS1)
   04920 Adipocytokine signaling pathway
    100512686 (IRS1)
   04935 Growth hormone synthesis, secretion and action
    100512686 (IRS1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100512686 (IRS1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100512686 (IRS1)
  09149 Aging
   04211 Longevity regulating pathway
    100512686 (IRS1)
   04213 Longevity regulating pathway - multiple species
    100512686 (IRS1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    100512686 (IRS1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100512686 (IRS1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    100512686 (IRS1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100512686 (IRS1)
   04932 Non-alcoholic fatty liver disease
    100512686 (IRS1)
   04931 Insulin resistance
    100512686 (IRS1)
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 100512686
NCBI-ProteinID: NP_001231418
Ensembl: ENSSSCG00000025729
UniProt: C3S7K3
Position
15:complement(128245846..128307321)
AA seq 1241 aa
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAGPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPN
GHYILPRGGNGHRCLPGAGLGTSPALTGEEAGPASDLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRMPNYRHSAFVPTHSYPEEGLEMHPLERRGGHHR
QDTSSLHTDDGYMPMSPGVAPVPGTRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPSSGGSSSGAAPSGSSYGKLWTNGVGGHHSHALPHPKLPVES
SSGKLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEL
EESARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARPEPGLPHLHHQVLQPH
LPRKVDTAAQTNNRLARPTRLSLGDPKASTLPRAREQPPQPALLHPPEPKSPGEYVNIEF
GGDQPGYLSGPVASHSAPSVRCSSQLQPAPREENTGAEEYMNMDLGPGRRAIWQESAGVQ
PGRVGPAPPGAASVCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPISYADMRTGIVV
EEASLPGATAAAPSASSATSASSAAPQGAGELAACSSLLGGPQGPGGLSAFTRVNLSPNR
NQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNTVPFGGGAAVGGGGGGSSSTEAVKRH
SSASFENVWLRPGELGGAPKELAQMCGAAGGLENGLNYIDLDLVKNFKQRPQERPPQPQP
PPPPPPHQPLGNSESSSTSRSSEDLSAYASISFQKQPEDRQ
NT seq 3726 nt   +upstreamnt  +downstreamnt
atggcgagccctcccgagacggatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgctttttcgtgctgcgggcggccagcgaggctgggggc
cccgcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggattccaagaac
aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcggacagcgag
gccgaacaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggccgcaggccctggggcgggaggcggtgggggcagctgcagtggcagctct
ggcctcggcgaggctggggaggacttgagctatggggacgtgcccccaggacccgccttc
aaggaggtttggcaggtgatcctgaaacccaaaggcctgggtcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagtttcgtgaagctgaactcggag
gcggcggctgtggtgctgcagctgatgaacatcaggcgctgtggccactcagagaacttc
ttcttcatcgaagtgggccgttctgcagtgacgggacccggggagttttggatgcaggtg
gatgattctgtggtggcccagaatatgcatgagacaatcctggaggccatgcgggccatg
agcgatgagttccgccctcgaagcaagagccagtcctcctctaactgctccaaccccatc
agtgtacctctgcgcaggcaccacctcaacaaccctccgcccagccaggtggggctgacc
cgccgctcacgcacagagagcatcactgccacctccccggccagcttggtgggcgggaag
cagggctccttccgcgtccgtgcgtccagtgatggcgaaggcaccatgtctcgccccgcc
tctgtggatggcagtcctgtgagccctagcaccaacaggactcacgcccaccggcatcga
ggcagctcccggctgcacccgcctcttaaccacagccgctctattcccatgccttcttct
cgctgctcaccctccgccaccagcccggtcagcctgtcgtccagcagcaccagcggccat
ggctccacctcggactgtctcttcccgcggcggtctagtgcttctgtgtccgggtccccc
agtgacggcggtttcatctcttccgatgagtatggctctagcccctgtgatttccgaagc
tccttccgcagtgtcacgccagattccctgggccacaccccgcccgcccgcggtgaggag
gagctgagcaactacatctgcatggggggcaagggggcctccaccctcgctgcccccaat
ggccactacattttgcctcggggtggcaatggccaccgctgcctcccaggagctggcttg
ggcacgagcccagccctgaccggggaggaagcaggccctgcatctgatctggataaccgg
ttccgaaagcggactcactctgctggcacatcccctactatttcccaccagaagacccca
tcccagtcctctgtggcttccattgaggaatatacagagatgatgccggcctacccacca
ggaggtggcagtggaggccggatgcccaactaccggcactccgccttcgtgcccacccac
tcctaccctgaggagggtctggaaatgcaccccttggagcggcgtgggggtcaccaccgc
caagacacctccagcctccacaccgatgatggctacatgcccatgtccccaggagtagcc
ccagtgcccggcacccgaaagggcagtggggactacatgcccatgagccccaagagcgtg
tctgccccgcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtcccccagcggcagctgctctcctgacattggaggtggtcccagc
agcgggggcagcagcagcggtgccgccccttctgggagcagctatggcaagttatggaca
aatggggtagggggccaccactctcacgccctgccacaccccaaactccctgtggagagc
agtagtggcaagctcttgtcttgtacaggtgactacatgaacatgtcgccagtgggggac
tccaacaccagcagcccttccgactgctactatggccccgaagatccccagcacaagcca
gtcctctcctactactcgttgccaaggtccttcaagcacacgcagcgccccggggagctg
gaggagagcgccaggcaccagcacctccgcctttcctccagctccggtcggcttctctat
gctgcggcagcagaagattcgtcgtcatccaccagcagcgacagcctgggcgggggatac
tgtggggctaggcccgagcccggcctcccgcatctccatcatcaggtcctgcagccccat
ctgcctcgaaaggtggacacagcagcccagaccaacaaccgcctggctcggcccacgagg
ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagccgccgcag
ccggccctgctgcaccctccggaacccaaaagtccaggggaatatgtgaatattgaattt
gggggcgatcagccgggctacttatcaggcccggtggcgtcccacagcgcgccttcggtg
agatgttcatcgcagctccagccagctcccagagaagagaacactggcgccgaagagtac
atgaacatggacctggggccaggccggagggcgatctggcaggagagcgctggggtccag
cctggcagggtgggccccgcccccccgggagctgctagcgtgtgcaggccgacccgggcg
gtgcccagcagccggggtgactacatgaccatgcagatgggttgtccccgtcagagctac
gtggacacctcgccagtggcccccatcagctatgccgatatgcggaccggcatcgtcgtg
gaggaggccagccttcccggggccacagcggctgctccctcggcgtcctcggccacctct
gcttcctccgccgcgccccaaggagcaggggagctggcggcctgctcttccctgctgggg
ggcccgcagggacccgggggcctgagcgccttcacacgggtgaatctcagtcccaaccgc
aaccagagtgccaaagtgatccgtgccgaccctcaagggtgcaggaggcggcacagctcc
gagaccttctcctcgacacccagtgccacccgggcgggcaacacggtacccttcggaggg
ggagctgcagtcgggggcggcggtggtggcagcagcagcactgaggctgtgaaacgccac
agctctgcctccttcgagaacgtgtggctgaggcctggggagcttgggggagcccccaag
gagctggcccagatgtgcggagcagctgggggtttggagaatggtcttaactacatagac
ctggatttggtcaagaacttcaaacagcgccctcaagagcgcccccctcaaccgcagcct
cctccaccccctcctcctcatcagcctctgggcaacagtgagagcagctccaccagccgc
tccagcgaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggaccgt
cagtag

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (20)   
   KEGG PATHWAY (20)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (11)   
   RefSeq(nuc) (3)   
   GenBank (4)   
   EMBL (4)   
Protein domain (3)   
   Pfam (3)   
All databases (58)   

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