KEGG   Sus scrofa (pig): 397109
Entry
397109            CDS       T01009                                 
Symbol
DPYD
Name
(RefSeq) dihydropyrimidine dehydrogenase [NADP(+)] precursor
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00240  Pyrimidine metabolism
ssc00410  beta-Alanine metabolism
ssc00770  Pantothenate and CoA biosynthesis
ssc00983  Drug metabolism - other enzymes
ssc01100  Metabolic pathways
Module
ssc_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    397109 (DPYD)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    397109 (DPYD)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    397109 (DPYD)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    397109 (DPYD)
Enzymes [BR:ssc01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     397109 (DPYD)
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 NAD_binding_8 Fer4_10 Dus Fer4_7 Pyr_redox_3 Pyr_redox Fer4_6 Fer4_2 Fer4_9 FAD_oxidored Fer4
Other DBs
NCBI-GeneID: 397109
NCBI-ProteinID: NP_999209
Ensembl: ENSSSCG00000006878
UniProt: Q28943
Structure
Position
4:119931471..120712461
AA seq 1025 aa
MAPVLSKDVADIESILALNPRTQSHAALHSTLAKKLDKKHWKRNPDKNCFHCEKLENNFG
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTHLDIKSFITSISNKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGSINIGGLQQFASEVFKAMNIPQIRNPCLPSQE
KMPEAYSAKIALLGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSENEITLNTLKEEGYKAAFIGIGLPEPKTDDIFQGLTQD
QGFYTSKDFLPLVAKSSKAGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGARRVF
LVFRKGFVNIRAVPEEVELAKEEKCEFLPFLSPRKVIVKGGRIVAVQFVRTEQDETGKWN
EDEDQIVHLKADVVISAFGSVLRDPKVKEALSPIKFNRWDLPEVDPETMQTSEPWVFAGG
DIVGMANTTVESVNDGKQASWYIHKYIQAQYGASVSAKPELPLFYTPVDLVDISVEMAGL
KFINPFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIVRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWMELSRKAEAS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGAGKRTTYGGVSGTAIRPIALRAVTT
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIQDYCTGLKALLYL
KSIEELQGWDGQSPGTESHQKGKPVPRIAELMGKKLPNFGPYLEQRKKIIAEEKMRLKEQ
NAAFPPLERKPFIPKKPIPAIKDVIGKALQYLGTFGELSNIEQVVAVIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTVTDTCTGCTLCLSVCPIIDCIRMVSRTTPYEPKRGLPLA
VNPVC
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggcccctgtgctgagcaaggacgtggcggacatcgagagtatcctggctttaaatcct
cgaacacagtctcatgcagcccttcattccactttggccaagaaattggataagaaacac
tggaaaagaaatcccgataagaactgctttcattgcgagaagctggagaataattttggt
gacatcaagcacacgactcttggtgagcgaggagctctccgagaagcaatgagatgcctg
aaatgtgccgatgctccctgtcagaagagctgtccaactcatctagatatcaaatcattc
atcacaagtatctcaaataagaactattatggagctgctaagatgattttttctgacaac
cctcttggtctgacctgtggaatggtatgtccaacctctgatctttgtgtaggaggatgc
aatttatatgcaactgaagagggatcaattaatattggtggattgcagcagtttgcttct
gaggtgttcaaagcaatgaatatcccacaaatcaggaatccttgtctgccatcccaagag
aaaatgcctgaagcttattctgcaaagattgctcttttgggtgctgggcctgcaagtata
agctgtgcttccttcttggctcgattaggctactctgacatcactatatttgaaaaacaa
gaatatgttggtggtttaagtacttctgaaatccctcagttccggctgccatatgatgta
gtgaattttgagattgagcttatgaaggaccttggtgtaaagataatttgtggtaaaagc
ctttcagagaatgaaattactctcaacactttaaaagaagaagggtataaagctgctttc
attggtataggtttgccagaacccaaaacggatgacatcttccaaggcctgacacaggac
caggggttttacacatccaaagactttctgccccttgtagccaaaagcagtaaagcagga
atgtgtgcctgtcactctccattgccatcgatacggggagccgtgattgtactcggagct
ggagacacagctttcgactgtgcaacatccgctttacgttgtggagcccgccgagtgttc
ctcgtcttcagaaaaggctttgttaatataagagctgtccctgaggaggtggagcttgct
aaggaagaaaaatgtgaatttttgcctttcctgtccccacggaaggttatagttaaaggt
gggagaattgttgccgtgcaatttgttcgaacagaacaagatgaaactggaaaatggaat
gaagatgaagatcagatagtccatctgaaggctgatgtggtcatcagtgcctttggctca
gtgctgagggatcctaaagtaaaagaagccttgagccctataaaatttaacagatgggat
ctcccagaagtagatccagaaactatgcaaaccagtgaaccatgggtgtttgcaggtggt
gatatcgttggtatggctaacactacggtggaatccgtaaatgacggaaagcaggcctcc
tggtacattcacaaatatatccaggcccaatatggagcttcagtttctgccaagcccgaa
ctgcccctgttttatacgcctgttgacctggtggacatcagcgtggaaatggctggatta
aagtttataaatccttttggtcttgccagtgcagctccaactaccagttcatcgatgatt
cgaagagcttttgaagctggatggggttttgccctgaccaaaactttctctcttgataag
gacatagtgacaaatgtctcacccagaatcgtccgggggactacctctggccccatgtac
ggccctggacaaagctccttcctgaatattgagctcatcagtgaaaaaacagctgcatat
tggtgtcaaagtgtcactgaactaaaagctgactttccagacaatattgtgatcgccagc
atcatgtgtagttacaacaaaaatgactggatggaactctccagaaaggctgaggcctct
ggagcagatgccttggagttaaatctgtcatgtccacacggcatgggagaaagaggaatg
ggcctggcttgtgggcaggatccagagctggtgcggaacatctgtcgctgggttaggcaa
gctgttcagattcccttttttgccaagttgaccccaaacgtcactgatatagtaagcatc
gccagagcggccaaggaaggtggcgcagatggtgttacagccaccaacacggtctcaggt
ctcatgggattaaaagccgatggcacgccctggccagcggtgggtgctggcaagcggact
acatacggaggagtgtctggcacggccatcagaccaattgctttgagagctgtgaccacc
attgctcgtgctttgcctggatttcccattttggctactggtggaattgactcagctgaa
agtggacttcagtttctccacagtggtgcttcggtcctccaggtatgcagtgctgttcag
aatcaggatttcactgtcatccaagactattgcactggcctcaaagccttgctttatctg
aaaagcattgaagaactacaaggctgggatgggcagagtccaggtaccgagagtcaccag
aaggggaaaccagttcctcgtattgctgaactcatgggaaagaaactgccaaattttgga
ccttatctggagcaacgcaagaaaatcatagcagaggaaaagatgagactgaaagaacaa
aatgcagcttttccaccacttgagagaaaaccttttattcccaaaaagcctattcctgct
attaaggatgtaattggaaaagcactgcagtaccttggaacgtttggtgaactgagcaac
atagagcaagttgtggctgtgatcgatgaagaaatgtgtatcaactgtggcaaatgctac
atgacctgtaatgactctggctaccaggctatccagtttgatcccgaaacccacctgccc
accgttactgacacttgcacaggctgtaccctgtgtctctccgtctgccctattatcgac
tgcatcagaatggtttccaggacaacaccttacgaaccaaagagaggcttgcccttggct
gtgaatccggtgtgctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
3D Structure (13)   
   PDB (13)   
Protein domain (15)   
   Pfam (15)   
All databases (80)   

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