KEGG   Sus scrofa (pig): 397180
Entry
397180            CDS       T01009                                 
Symbol
MTHFR
Name
(RefSeq) methylenetetrahydrofolate reductase isoform X5
  KO
K25004  methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00670  One carbon pool by folate
ssc01100  Metabolic pathways
ssc01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    397180 (MTHFR)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    397180 (MTHFR)
Enzymes [BR:ssc01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.53  methylenetetrahydrofolate reductase (NADPH)
     397180 (MTHFR)
SSDB
Motif
Pfam: MTHFR
Other DBs
NCBI-GeneID: 397180
NCBI-ProteinID: XP_003127622
Ensembl: ENSSSCG00000003428
UniProt: A0A8D0HX37 F1RF82
Position
6:complement(71863637..71882118)
AA seq 659 aa
MVNEPRGNGGPGPRCEGSSSGSESSKESSRCSTPGLDPERHERLREKMKRRMESGDKWFS
LEFFPPRTAQGAVNLISRFDRMGAGGPLFIDVTWHPAGDPGSDKETSSMVIASTAVNYCG
LETILHMTCCHQSREEVTGYLHKAKRLGLKNILALRGDPVGDQWEAEEGGFSYAADLVKH
IRSEFGDYFDVCVAGYPKGHPDAESFEADLKHLKEKVAAGADFIITQLFFEADTFFRFLK
ACSEMGITCPILPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQ
AVSLCQELLASGLVPGLHFYTLNREVATTEVLKRLGLWIEDPRRPLPWAVSAHPKRREED
VRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMW
GQELTSEESVFEVFAHYLSGEPNQNGYKVTCLPWNDEPLAAETSLMKEELLRVNRRGILT
INSQPNINGKPSSDPVVGWGPSGGYVFQKAYLEFFTARETVEALLQVLKKYELRVNYHIV
DVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEE
ESPSRMLIQYIHDNYFLVNLVDNEFPLDNCLWQVVEDTFELLNRPPHNEKEPEASDPAP
NT seq 1980 nt   +upstreamnt  +downstreamnt
atggtgaacgaacccagagggaacggcggccccggcccccgctgtgagggcagcagcagt
ggcagcgagagctccaaggagagctcaaggtgctctacaccggggctggaccccgagcgt
cacgagaggctcagggagaagatgaagcggaggatggagtcaggtgacaagtggttctcc
ctagaattcttccctcctcgaactgctcagggcgccgtcaatctcatctctaggtttgac
cggatgggggcaggcggccctctcttcatagatgtgacctggcacccagcaggggaccct
ggctcggacaaggagacctcgtccatggtgatcgccagcacggccgtgaactactgcggc
ctggagaccatactgcacatgacctgctgccatcagagccgggaggaggtcacgggctac
ctgcacaaggccaagcggctgggcctgaagaacatcttggcgctgaggggagaccctgta
ggtgaccagtgggaagcagaggaaggaggcttcagctacgctgcagacttggtgaagcac
atccgcagcgagtttggtgactacttcgacgtctgtgtggcaggttaccccaaaggccac
cccgacgcagagagcttcgaggccgacctgaaacacctgaaggagaaggtggcggcagga
gccgacttcatcatcacccagcttttcttcgaggctgatacgttcttccgcttcttgaag
gcttgctccgagatgggcatcacctgccccatcctcccgggcatcttccccatccagggc
taccactccctccggcagctcgtgaagctgtccaagctggaggtgccgcagcagatcaag
gacgtgatcgagcccatcaaagacaatgacgccgccatccgcaactatggcatcgagcag
gctgtgagcttgtgccaggagcttctggccagtggcctggtgccgggcctccacttctat
accctcaaccgcgaggtggccaccacagaggtgctgaagcgtctgggcctgtggatcgag
gaccccaggcgccccctgccctgggctgtcagcgcccaccccaagcgtcgggaggaagat
gtccgtcccatcttctgggcctccagacccaagagttacatttaccgcacccaggagtgg
gatgaattccccaacggccgctggggcaactcctcctctcccgcctttggggagctgaag
gactactacctcttctacctgaagagcaagtccccgaaggaagagctgctgaagatgtgg
gggcaggagctgaccagcgaagagagtgtctttgaagtctttgcccactacctctcgggg
gagccgaaccagaatggctataaagtgacctgcctgccctggaatgacgagcccctggcg
gccgagaccagcctgatgaaggaggagctgctgcgggtgaaccggcggggcatcctcacc
atcaactcccagcccaacatcaacgggaagccgtcctccgaccccgtcgtgggctggggc
cccagcgggggctacgttttccagaaggcctacctggagttcttcactgcccgggagacg
gtggaggcgctcttgcaggtgctgaagaagtatgagctccgagtgaattatcacatcgtg
gatgtgaagggtgaaaacatcaccaacgcgcccgagctgcagcccaatgccgtcacttgg
ggcatcttccctggacgggagatcatccagcccacggtggtggacccggtcagcttcatg
ttctggaaggacgaggccttcgcgctgtggatcgagcagtggggcaaactgtacgaggag
gagtccccgtcccgcatgctcatccagtacatccacgacaactacttcctggtcaacctg
gtggacaacgagtttccgctggacaactgcctctggcaggtggtggaggacacatttgag
cttctcaacaggcccccccacaacgagaaggagcccgaggccagtgaccctgcgccctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   RefSeq(pep) (9)   
DNA sequence (24)   
   RefSeq(nuc) (10)   
   GenBank (7)   
   EMBL (7)   
Protein domain (1)   
   Pfam (1)   
All databases (63)   

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