KEGG   Sus scrofa (pig): 397350
Entry
397350            CDS       T01009                                 
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor precursor
  KO
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc01521  EGFR tyrosine kinase inhibitor resistance
ssc01522  Endocrine resistance
ssc04010  MAPK signaling pathway
ssc04014  Ras signaling pathway
ssc04015  Rap1 signaling pathway
ssc04066  HIF-1 signaling pathway
ssc04068  FoxO signaling pathway
ssc04114  Oocyte meiosis
ssc04140  Autophagy - animal
ssc04144  Endocytosis
ssc04150  mTOR signaling pathway
ssc04151  PI3K-Akt signaling pathway
ssc04152  AMPK signaling pathway
ssc04211  Longevity regulating pathway
ssc04213  Longevity regulating pathway - multiple species
ssc04510  Focal adhesion
ssc04520  Adherens junction
ssc04550  Signaling pathways regulating pluripotency of stem cells
ssc04730  Long-term depression
ssc04913  Ovarian steroidogenesis
ssc04914  Progesterone-mediated oocyte maturation
ssc05200  Pathways in cancer
ssc05202  Transcriptional misregulation in cancer
ssc05205  Proteoglycans in cancer
ssc05214  Glioma
ssc05215  Prostate cancer
ssc05218  Melanoma
ssc05224  Breast cancer
ssc05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    397350 (IGF1R)
   04014 Ras signaling pathway
    397350 (IGF1R)
   04015 Rap1 signaling pathway
    397350 (IGF1R)
   04066 HIF-1 signaling pathway
    397350 (IGF1R)
   04068 FoxO signaling pathway
    397350 (IGF1R)
   04151 PI3K-Akt signaling pathway
    397350 (IGF1R)
   04152 AMPK signaling pathway
    397350 (IGF1R)
   04150 mTOR signaling pathway
    397350 (IGF1R)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    397350 (IGF1R)
   04140 Autophagy - animal
    397350 (IGF1R)
  09143 Cell growth and death
   04114 Oocyte meiosis
    397350 (IGF1R)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    397350 (IGF1R)
   04520 Adherens junction
    397350 (IGF1R)
   04550 Signaling pathways regulating pluripotency of stem cells
    397350 (IGF1R)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    397350 (IGF1R)
   04914 Progesterone-mediated oocyte maturation
    397350 (IGF1R)
  09156 Nervous system
   04730 Long-term depression
    397350 (IGF1R)
  09149 Aging
   04211 Longevity regulating pathway
    397350 (IGF1R)
   04213 Longevity regulating pathway - multiple species
    397350 (IGF1R)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    397350 (IGF1R)
   05202 Transcriptional misregulation in cancer
    397350 (IGF1R)
   05205 Proteoglycans in cancer
    397350 (IGF1R)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    397350 (IGF1R)
   05214 Glioma
    397350 (IGF1R)
   05218 Melanoma
    397350 (IGF1R)
   05215 Prostate cancer
    397350 (IGF1R)
   05224 Breast cancer
    397350 (IGF1R)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    397350 (IGF1R)
   01522 Endocrine resistance
    397350 (IGF1R)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssc01001]
    397350 (IGF1R)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:ssc04090]
    397350 (IGF1R)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     397350 (IGF1R)
Protein kinases [BR:ssc01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   397350 (IGF1R)
CD molecules [BR:ssc04090]
 Proteins
  397350 (IGF1R)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like fn3 Kinase-like DUF4476 Insulin_TMD
Other DBs
NCBI-GeneID: 397350
NCBI-ProteinID: NP_999337
Ensembl: ENSSSCG00000030576
UniProt: A0A8D0IGG5 F1CK17
Position
1:complement(137383623..137691038)
AA seq 1367 aa
MKSGSGGGSPTSLWGLLFFSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTLEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENHECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPSCPPNTYRFEGWRCVDRDFCANIPSAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRH
NYCSKDKIPIRKYADGTIDVEEATENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNAIFVPRPERKRREVMQVANTTMSSRSRNTTVVDTYNVTDPEELETEYPFFES
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTEPVFFYVQAKTTYENFIHLIIALPVAVLLIVGGLVIMLYVFHR
KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGV
VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
EIISSIKDEMEPGFREVSFYYSEENKPPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
NT seq 4104 nt   +upstreamnt  +downstreamnt
atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcctgtttttctcc
gccgcgctctcgctctggccgacgagtggagaaatctgcgggccgggcattgacatccgc
aacgactaccagcagctgaagcgcctggagaactgcacggtgatcgagggctacctccac
atcctgctcatctccaaggctgaggactaccgcagctaccgctttcccaagctcacggtc
atcaccgagtacctgctgctgttccgtgtggctggccttgagagccttggcgacctcttc
cccaatctcacggtcatccgcggctggaagctcttctacaactacgccctggtcatcttc
gagatgaccaacctcaaggacatcgggctctacaacctgaggaatattacccggggggcc
atcaggatcgagaagaatgccgacctctgctacctctctacggtggactggtccctgatc
ctggatgccgtgtccaataactacatcgtgggcaacaagccccctaaggaatgcggggac
ttgtgcccagggacgctggaggagaagccgctgtgtgagaagacgaccatcaacaacgag
tacaactatcgctgctggaccacgaaccgctgccagaaaatgtgcccgagcgtgtgcggg
aagcgggcgtgcacagagaaccacgagtgctgccaccccgagtgcctgggcagctgcagc
gcacccgacaacgacacagcctgtgtggcctgccgccactactactacgccggagtctgc
gtgcccagctgcccacccaacacctaccgcttcgagggctggcgctgcgtggaccgcgac
ttttgcgccaacatccccagtgcggagagcagtgactccgagggctttgtgatccatgat
ggcgagtgcatgcaggagtgcccttcaggcttcatccgcaatggcagccagagcatgtac
tgtatcccttgcgaaggcccttgccccaaagtctgtgaggaagagaagaagacaaagacc
attgattctgtcacttctgctcagatgctccaaggatgcaccatcttcaagggcaacctg
ctcattaacatccgacgcggcaacaacattgcctcggagctagagaacttcatggggctc
atcgaggtggtgacgggctacgtgaagatccgccactcccatgccttggtctccttgtcc
ttcctgaaaaatcttcgccagatcctaggggaggagcagctggaggggaattactccttc
tacgtccttgacaaccagaacttgcagcagctgtgggactgggaccatcgcaacctgacc
atcaaagctgggaaaatgtactttgctttcaatcccaaattgtgtgtctccgagatttac
cgcatggaggaagtgacagggactaaagggcgccagagcaaaggggacataaacaccagg
aacaatggagagagagcctcctgtgaaagtgacgtcctgcacttcacctccaccaccacg
tggaagaaccgcatcatcatcacctggcaccgataccggccccctgactacagggacctc
atcagcttcactgtctactacaaggaagcgccctttaaaaacgtcacggagtatgatggg
caggatgcctgtggctccaacagctggaacatggtggacgtggacctccctcccaataag
gacgtcgagcctggcattctactgcatgggctgaagccctggacacagtacgctgtttac
gtcaaggccgtgaccctcaccatggtggagaatgaccacatccgtggggccaagagtgag
atcttgtacattcgcaccaatgcttcagttccttccattcccctggatgtcctctcagca
tcaaactcctcttctcagctgatagtgaagtggaacccgccctccctgcccaatggcaac
ctgagctactacatcgtgcggtggcagcgccagcctcaggacagctatctctaccggcat
aattactgctccaaagacaaaatccccatcaggaagtatgctgatggcaccattgatgtc
gaggaggctacagagaaccccaagactgaagtgtgtggcggggagaagggaccatgctgt
gcttgccccaaaacagaagctgagaagcaggcagagaaggaggaggctgagtaccgcaag
gtcttcgagaacttcctgcacaatgccatctttgtgcccagacctgaacggaagcggagg
gaggtcatgcaggtcgccaacaccaccatgtccagccggagcagaaacaccacagtggtg
gacacctacaatgtcacggacccagaggagcttgagacagagtaccctttttttgagagc
agagtggataacaaggagagaactgtcatttccaacctccggccttttactttgtaccga
attgacatccacagctgtaaccatgaggctgagaagctgggctgcagtgcctccaacttt
gtctttgcaagaaccatgcctgcagaaggagcagatgacattcctgggccagtgacctgg
gagccacggcctgagaactccatctttttaaagtggccagaacctgagaatcctaatgga
ttgattctaatgtatgaaataaaatacggatcacaagtcgaggatcagcgggaatgtgtg
tccagacaggagtacaggaagtatggaggggccaagctgaacaggctcaacccggggaac
tacacggcccggattcaggccacctctctctccgggaatgggtcatggacggaacctgtg
ttcttctacgtccaggccaaaacgacatatgaaaacttcatccatctgatcatcgcccta
ccagtggccgttctgttgatagtaggagggttggttataatgttgtacgtcttccacaga
aagagaaataacagcaggctggggaatggagtgctgtatgcttccgtgaacccggagtac
ttcagcgcagctgatgtgtacgtgcccgacgagtgggaggtcgcccgggagaagatcacc
atgagccgggagctgggacagggctccttcgggatggtttatgaaggcgtcgccaagggt
gtggtcaaagatgagcctgagaccagggtggccattaagacagtgaatgaggccgccagc
atgcgtgagaggattgagtttctcaacgaggcctccgtgatgaaggagttcaactgtcac
cacgtggtgcggctgctgggtgtggtgtcccagggccagccaacgctggtcatcatggaa
ctgatgacccggggggacctcaaaagttatctccggtctctgagaccagaaatggagaat
aatccagtcctagcacctccaagcctaagcaaaatgatccagatggctggagagattgca
gatggcatggcatacctcaacgccaataagtttgtccacagagacctcgctgcccggaac
tgtatggtggccgaagacttcacagtcaaaatcggagattttgggatgacgagagacatc
tatgagacagactattaccgcaagggagggaaagggctgctgcctgtgcgctggatgtcc
cctgagtccctcaaggacggagtcttcaccacgcactctgatgtctggtccttcggggtc
gtcctctgggagattgccacgctggccgagcagccataccagggcttgtccaacgagcaa
gtccttcgcttcgtcatggagggcggccttctggacaagccggacaactgtcccgacatg
ctgtttgagctgatgcgcatgtgctggcagtacaaccccaagatgaggccttccttcctg
gagatcatcagcagcatcaaggacgagatggagcctggcttccgggaggtctccttctac
tacagtgaggagaacaagccgcctgagccggaggagctggacctggagccggagaacatg
gagagcgtccccctggacccctcggcctcctcgtcctccctgccgctgcccgacagacac
tcaggacacaaggctgagaacggcccaggccctggcgtgctggtgctgcgagccagcttc
gacgagagacagccttacgcgcacatgaacgggggccgcaagaacgagcgggccctgcct
ctgccccagtcctcgacctgctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (29)   
   KEGG PATHWAY (29)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   RefSeq(pep) (4)   
DNA sequence (16)   
   RefSeq(nuc) (4)   
   GenBank (6)   
   EMBL (6)   
Protein domain (8)   
   Pfam (8)   
All databases (82)   

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