KEGG   Sus scrofa (pig): 397447
Entry
397447            CDS       T01009                                 
Symbol
ROCK1
Name
(RefSeq) rho-associated protein kinase 1
  KO
K04514  Rho-associated protein kinase 1 [EC:2.7.11.1]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc04022  cGMP-PKG signaling pathway
ssc04024  cAMP signaling pathway
ssc04062  Chemokine signaling pathway
ssc04071  Sphingolipid signaling pathway
ssc04270  Vascular smooth muscle contraction
ssc04350  TGF-beta signaling pathway
ssc04360  Axon guidance
ssc04510  Focal adhesion
ssc04520  Adherens junction
ssc04530  Tight junction
ssc04611  Platelet activation
ssc04670  Leukocyte transendothelial migration
ssc04810  Regulation of actin cytoskeleton
ssc04921  Oxytocin signaling pathway
ssc05135  Yersinia infection
ssc05163  Human cytomegalovirus infection
ssc05200  Pathways in cancer
ssc05205  Proteoglycans in cancer
ssc05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    397447 (ROCK1)
   04071 Sphingolipid signaling pathway
    397447 (ROCK1)
   04024 cAMP signaling pathway
    397447 (ROCK1)
   04022 cGMP-PKG signaling pathway
    397447 (ROCK1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    397447 (ROCK1)
   04520 Adherens junction
    397447 (ROCK1)
   04530 Tight junction
    397447 (ROCK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    397447 (ROCK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    397447 (ROCK1)
   04670 Leukocyte transendothelial migration
    397447 (ROCK1)
   04062 Chemokine signaling pathway
    397447 (ROCK1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    397447 (ROCK1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    397447 (ROCK1)
  09158 Development and regeneration
   04360 Axon guidance
    397447 (ROCK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    397447 (ROCK1)
   05206 MicroRNAs in cancer
    397447 (ROCK1)
   05205 Proteoglycans in cancer
    397447 (ROCK1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    397447 (ROCK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    397447 (ROCK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssc01001]
    397447 (ROCK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ssc03036]
    397447 (ROCK1)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     397447 (ROCK1)
Protein kinases [BR:ssc01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   397447 (ROCK1)
Chromosome and associated proteins [BR:ssc03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    397447 (ROCK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 Cortex-I_coil Pkinase_C APH
Other DBs
NCBI-GeneID: 397447
NCBI-ProteinID: XP_005653457
Ensembl: ENSSSCG00000021893
UniProt: I3LCJ1 A0A4X1VPV6
Position
6:complement(106163899..106314998)
AA seq 1354 aa
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSAANPNDNRASSNV
DKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
LSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
AQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSITQLESLNRELQERNRILENSKSQTD
KDYYQLQAVLEAERRDRGRDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKDAQDMLN
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLTLQLEQES
NKRLLLQNELKTQAFESDNLKGLQKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHIVSRLEETNSMLTKDIDLLRKENE
ELTDKMRKAEEEYKLKKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSIPNRGNIKRYGWKK
QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALE
CRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
PSSFVRASPRTLSTRSTANQSFRKVVKNTSGKTS
NT seq 4065 nt   +upstreamnt  +downstreamnt
atgtcgactggggacagttttgagactcggtttgaaaaaatcgacaacttgctgcgggat
cccaaatcggaagtgaattcagattgtttgctggatggattggatgctttggtgtatgat
ttggattttcctgccttaagaaaaaacaaaaatattgacaactttttaagcagatataaa
gacacaataaataaaattagagatttacgaatgaaagctgaagattatgaagtagtgaaa
gtgattggtagaggtgcatttggagaagttcaattggtaaggcataaatccacaaggaag
gtatatgctatgaagcttctcagcaaatttgaaatgattaagagatctgattctgctttt
ttctgggaagaaagggacatcatggcttttgctaatagtccttgggttgtgcagctgttt
tatgcattccaagatgatcgttatctctacatggtaatggaatacatgccaggtggagat
cttgtaaacttaatgagcaactatgatgtgcctgaaaaatgggcccgattctatactgca
gaagtagtccttgcattggatgcaatccactccatgggttttattcatagagatgtgaag
cctgataatatgctgctggataaatctggacatttgaagttagcagattttggtacttgt
atgaagatgaataaggaaggtatggtacgatgtgatacagcagttggaacacctgattat
atttcccctgaagtattaaagtctcaaggtggcgatggttattatggacgagaatgtgac
tggtggtcagttggagtatttttatatgaaatgcttgttggtgatacaccattttatgca
gattctttggttggaacttacagtaagattatgaatcataaaaattcacttaccttccct
gatgataatgatatatcaaaagaagcaaaaaatcttatttgtgccttccttactgacagg
gaggtgagattagggcgaaatggtgtagaagaaatcaagcgacatctcttcttcaaaaat
gaccagtgggcttgggaaacactccgagacactgtggcaccagttgtacctgatttaagt
agtgacattgacacaagtaactttgatgacttggaagaagataaaggagatgaagaaaca
ttccctatacctaaagcttttgttggcaatcaactaccttttgtaggatttacatattat
agcaatcgtagatacttatctgccgcaaatcctaacgataacagagctagttctaatgtg
gataaaagcttgcaggaaaatttgcaaaaaacaatttataagttggaagaacagctgcat
aatgaaatgcaattaaaagatgaaatggagcagaagtgcagaacttcaaacataaagcta
gacaagataatgaaagaattggatgaagaggggaatcaaagaagaaatctagaatctaca
ttgtctcagatcgaaaaggagaaaatgttgctacagcacagaattaatgagtaccaaaga
aaagcagaacaggaaaatgagaagaggaggaatgtagaaaatgaagtttctacattaaag
gatcagttggaagacttaaagaaagtcagtcagaattcacagcttgcgaatgagaagctg
gcacagttacaaaagcagctagaagaagccaatgacttacttaggacagaatcagacaca
gctgtaaggttaaggaagagtcacactgagatgagcaagtcaattactcagctggagtcc
cttaacagagaactgcaggagagaaatagaattttagagaattcaaaatcacaaacagac
aaggattattaccagctgcaagctgtattagaagctgaacgaagagacagaggtcgtgat
tctgagatgattggagacctacaagctcgaattacatctttacaagaggaggtgaagcat
ctcaaacataatcttgaaagagtggaaggagaaagaaaagatgctcaagacatgcttaat
cattcagaaaaggaaaagaataatttagaaatagatttaaactataagcttaaatcatta
cagcaacggttagaacaagaggtaaatgaacataaagtaaccaaagctcgtttaactgac
aaacatcaatctattgaagaagcaaagtctgttgcaatgtgtgagatggagaaaaagctt
aaggaagagagagaagctcgagagaaagctgaaaatagggttgttcaaattgagaagcag
tgctccatgttagacgttgatctaaaacaatctcagcagaaactagagcatttgaccgaa
aataaagaaagaatggaggatgaagttaagaatctaaccctccaactggagcaggaatca
aataagcgactattgttacaaaatgaattgaagactcaagcatttgagtcagacaattta
aaaggtttacaaaagcagatgaaacaggaaataaatacattattggaagcaaaaagattg
ttagaatttgagttagctcagcttacaaaacaatacagaggaaatgaagggcagatgcgg
gagctacaagatcagcttgaagcagagcaatatttctcgacactttataaaacccaggta
aaggaacttaaggaagaaattgaagaaaaaaacagagaaaatttaaagaaaatacaggaa
ctgcaaaatgaaaaagaaactcttgcaactcagttggatctagcagaaacaaaagctgag
tctgagcagttagctcgaggacttctggaagaacagtattttgaattgactcaagaaagc
aagaaagctgcttcaagaaataggcaagagattacggataaagatcacatagttagtcgg
ctcgaagaaacgaacagcatgctaaccaaagatattgatttactaagaaaagaaaatgaa
gagctaactgataaaatgaggaaggcagaggaagaatataaattgaagaaggaggaggag
atcagtaatcttaaggccgcctttgaaaagaatatcaatactgaacgaactcttaaaaca
caggctgttaacaagttggcagaaataatgaatcggaaagattttaaaattgatagaaag
aaagctaatacacaggatttgagaaagaaagaaaaggaaaatcgaaagctacaacttgaa
ctcaaccaagagagagagaaattcaaccagatggtcgtgaaacatcagaaggaattgaat
gacatgcaagcgcaattggtagaagaatgtacacataggaatgagcttcagatgcagttg
gctagcaaagagagtgatattgaacaattgcgggcgaaacttttggacctttcggattct
acaagtgttgcgagttttcctagtgctgatgaaactgatggaaaccttccagaatcaaga
attgaaggttggctttcaataccaaatagaggaaatatcaaacgatatggctggaagaaa
cagtatgttgtggtaagcagcaaaaaaatcttgttctataatgatgaacaagataaggaa
caatccaatccgtctatggtgttggacattgataaattgtttcatgttcgacctgtaacc
caaggagatgtgtatagagctgaaactgaagaaattcctaagatattccagatactatat
gcaaacgaaggtgaatgtagaaaagacgtagagatggaaccagtacaacaagctgaaaaa
actaattttcaaaaccacaaaggccatgagttcatccctaccctctaccactttcctgcc
aactgtgaggcctgtgccaaacctctctggcatgtttttaagccaccccctgccctagaa
tgtcgaagatgccacgttaagtgccacagagatcacttagataagaaggaggacttaatt
tctccttgtaaagtaagttatgatgtaacatcagcaagagatatgctgctcttagcatgt
tctcaggatgaacaaaaaaaatgggtaactcatttagtaaagaagatccctaagaatcca
ccatctagttttgttcgtgcatcccctcgaacactttctacaagatccactgcaaatcag
tctttccgaaaagtggtcaaaaatacatctggaaaaactagttaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (19)   
   KEGG PATHWAY (19)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (8)   
   Pfam (8)   
All databases (62)   

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