KEGG   Sus scrofa (pig): 403154
Entry
403154            CDS       T01009                                 
Symbol
CFTR
Name
(RefSeq) cystic fibrosis transmembrane conductance regulator
  KO
K05031  cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc02010  ABC transporters
ssc04024  cAMP signaling pathway
ssc04152  AMPK signaling pathway
ssc04530  Tight junction
ssc04971  Gastric acid secretion
ssc04972  Pancreatic secretion
ssc04976  Bile secretion
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    403154 (CFTR)
  09132 Signal transduction
   04024 cAMP signaling pathway
    403154 (CFTR)
   04152 AMPK signaling pathway
    403154 (CFTR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    403154 (CFTR)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    403154 (CFTR)
   04972 Pancreatic secretion
    403154 (CFTR)
   04976 Bile secretion
    403154 (CFTR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:ssc02000]
    403154 (CFTR)
Enzymes [BR:ssc01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.1  Enzymes altering polypeptide conformation or assembly
    5.6.1.6  channel-conductance-controlling ATPase
     403154 (CFTR)
Transporters [BR:ssc02000]
 ABC transporters, eukaryotic type
  ABCC (CFTR/MRP) subfamily
   ABCC7 subgroup
    403154 (CFTR)
SSDB
Motif
Pfam: CFTR_R ABC_membrane ABC_tran SMC_N AAA_21 AAA_29 AAA_16 T2SSE RsgA_GTPase DO-GTPase2 DUF87 MeaB nSTAND3 Zeta_toxin NTPase_1 Intein_splicing Biotin_lipoyl_2
Other DBs
NCBI-GeneID: 403154
NCBI-ProteinID: NP_001098420
Ensembl: ENSSSCG00000016626
UniProt: Q6PQZ2
Position
18:complement(28627717..28818209)
AA seq 1482 aa
MQRSPLEKASIFSKLFFSWTRPILRKGYRQRLELSDIYHISSSDSADNLSEKLEREWDRE
LASKKNPKLINALRRCFFWRFMFYGIILYLGEVTKAVQPLLLGRIIASYDPDNKAERSIA
IYLGVGLCLLFIVRTLLLHPAIFGPHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
VSLLSNNLNKFDEGLALAHFVWIAPLQVTLLMGLLWELLQASAFCGLAFLVVLALFQAGL
GKMMMKYRDQRAGKINERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA
YVRYFNSSAFFFSGLFVVFLSVLPYALLKGIMLRKIFTTISFCIVLRMAVTRQFPWAVQT
WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGKLFEKAKQNNNSRK
ISNGDNSLFFSNFSLLGTPVLKDISFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEG
KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV
LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR
ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQSQRPDFSSKLMGYDTFDQFTAERRNS
IITETLRRFSLEGDASVSWNETKKQSFKQTGEFGEKRKNSILNSINSIRKFSIVQKTPLQ
MNGFEEDSGEPLERRLSLVPDSEHGEAILPRSNVINAGPTFQGRRRQSVLNLMTRSSVNQ
GQSIHRKTATSTRKMSLVPQANLTEIDIYSRRLSQDTGLEISEEINEEDLRECFFDDVES
IPTVTTWNTYLRYVTVHKSLIFVLIWCLVVFLAEVAACLVVLCLLKKTSPQDKGNSTKGA
NNSYAVIITSTSAYYVFYIYVGVADGLLALGLFRGLPLVHTLITVSKILHRKMLHSVLQA
PMSTLNTLKAGGILNRFSKDIAVLDDLLPLTIFDFIQLLLIVIGAVAVVSVLKPYIFLAT
VPVIVAFILLRAYFLHTSQQLKQLESEGRSPIFTHLITSLKGLWTLRAFGRQPYFETLFH
KALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGTVGIILTLAMNI
MSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPAEGDQPNRSFKPSKDGQLSKVMIIENQHV
KKDDIWPSGGQMTVKDLTAKYVDGGNAVLENISFSISPGQRVGLLGRTGSGKSTLLLAFL
RLLNTEGEIQVDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYGQWNDQEIWKV
AEEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLGKAKILLLDEPSAHLDP
ITYQIIRRTLKQAFADCTVILSEHRIEAMLECQRFLVIEENKVRQYDSIQRLLSEKSLFR
QAISPLDRLKLLPHRNSSKQRSRSKIAALKEETEEEVQETRL
NT seq 4449 nt   +upstreamnt  +downstreamnt
atgcagaggtcgcctctggaaaaggccagcatcttctccaaactttttttcagctggacc
agaccaattttgagaaaaggatatagacagcgcctggaattgtcagacatataccatatc
tcttcttctgactctgctgacaatctgtctgaaaaattggaaagagaatgggacagagaa
ctggcttcaaagaagaatcccaaactcattaatgcccttcggcgatgttttttttggaga
tttatgttctatggaatcatattatatttaggggaagtcaccaaagcagtccagcctctc
ttactgggaagaatcatagcttcctatgatccagataacaaggcggaacgctccattgcg
atttacctaggcgtaggcttatgtcttctcttcatcgtgaggactctgctcctgcaccca
gccatttttggcccccatcacattggcatgcagatgagaatagctatgtttagtttgatt
tacaaaaagactttgaagctgtcaagccgtgttctagataaaataagtattggacaactt
gttagtctcctttccaacaacctgaacaagtttgatgaaggacttgccttggcgcacttc
gtgtggatcgctcctctgcaagtgacgctgctgatggggctgctgtgggagttgttgcag
gcctccgccttctgtggacttgccttcctcgtagtcctcgccctctttcaagctgggttg
gggaaaatgatgatgaagtacagagatcagagagctggaaagatcaatgaaagactggtg
attacctcagagatgattgaaaatatccaatcagttaaagcatactgctgggaagaagcg
atggaaaaaatgattgaaaacctaagacaaacggaactgaaactgacccggaaggcagcc
tatgtgagatacttcaatagctcagccttcttcttctctgggctctttgtggtgttttta
tctgtgcttccctacgcactgctcaaaggaatcatgcttcgaaaaatcttcacaaccatc
tcattctgcattgttctgcgcatggcagtcacccggcaattcccctgggctgtacaaact
tggtatgattctcttggagcaataaacaaaatacaggatttcttacagaagcaagaatat
aagacactggaatacaacttaacaactacagaagtagtgatggagaatgtaacagccttc
tgggaagagggatttgggaaattatttgagaaagcaaaacaaaataataacagtcgaaaa
atttccaatggtgataacagcctcttcttcagtaacttttcacttctcggtactcctgtc
ctgaaagatatcagtttcaagatagaaagaggacaattgttggcagttgctggatctact
ggagcaggcaagacatcacttctgatgatgattatgggagaactggagccttcagagggt
aaaattaagcacagtggaagaatttcattctgctctcagttttcctggatcatgccgggc
accattaaagaaaacatcatctttggtgtttcctatgatgagtatagatacaggagtgtc
atcaaagcgtgccaactagaagaggacatctccaagtttgcagagaaagacaacatagtt
ctgggagaaggtggaatcacactgagtggaggtcagcgagcaagaatttctttagcaaga
gcagtatataaagatgctgatttgtacctattagactctccttttggatacctagatgtt
ttaacagagaaagaaatatttgaaagctgtgtctgtaaattgatggctaacaaaactagg
attttggtcacttctaaaatggaacatttaaagaaagctgacaaaatactaattttacat
gaaggtagcagctatttttatgggacattttctgaattacaaagtcagcggcccgacttc
agttcaaagcttatgggatatgatacttttgaccaatttactgcagaacggagaaattca
atcataactgagactttacggcgtttctcattagaaggagatgcctctgtgtcctggaac
gaaacaaaaaaacaatcctttaaacagactggagagtttggtgaaaaaaggaagaattcc
attctcaattcaatcaactctataaggaaattttcaattgtacaaaagactcccttacaa
atgaatggctttgaagaagattctggcgagcctttagagagaaggctgtccttagttcct
gattctgagcatggggaggcaattctacctcggagcaacgtgatcaacgctggccccacg
tttcagggacgacggaggcagtctgttctgaacctcatgacccgctcctcagtgaaccaa
ggtcaaagcattcaccgaaagacagcgacgtccacacggaaaatgtcactggtccctcaa
gcaaacttaactgaaatagatatatattccagacgattatcgcaagatactggcttggaa
ataagtgaagaaattaatgaagaagatttaagggagtgcttttttgatgacgtggagagc
ataccaaccgtgactacctggaacacatacctccgatatgttactgttcacaagagctta
atttttgtgctgatttggtgcttagttgtttttctggctgaggtggctgcttgtttggtt
gtgttgtgtttgcttaaaaaaacatctcctcaagacaaagggaatagcactaagggtgca
aataacagctatgcagtaatcatcaccagcaccagcgcatactatgttttttacatttac
gtgggagtagccgacggtttgcttgctctgggactcttcagaggtttaccactggtgcat
actctaatcacagtgtcgaaaattttacatcgcaaaatgttacactctgttcttcaagcc
cctatgtcaaccctcaacacattgaaagcaggtgggattcttaatagattctccaaagat
atagcagttttggatgatctcctgcctcttactatatttgatttcatccagttactatta
attgtgattggagctgtggcagttgtctcagttttaaaaccttacatcttcctggcaaca
gtgccagtgatagtggcttttattctactgagagcctacttcctccacacttcacagcag
ctcaaacagctggaatctgaaggcaggagtccaattttcactcatctcattacaagctta
aaaggactatggacccttcgagcctttggacgtcagccttactttgaaactttgttccac
aaagctcttaatttacatactgccaactggttcttgtatctgtcaacactacgctggttc
caaatgcgaatagaaatgatttttgtcatctttttcattgccgttaccttcatttccatt
ttaacaacaggggaaggagaaggaacagttgggattattctaacattagccatgaatatc
atgagtacattgcagtgggctgtaaactccagtatagatgtggatagcttgatgcgatct
gtgagccgagtctttaagtttattgatatgccggcagaaggagatcaacctaacaggtcg
ttcaaaccatccaaggatggccagctttcaaaggttatgattattgagaatcaacatgtg
aagaaagatgacatctggccttcagggggccaaatgactgtcaaagacctcactgcgaaa
tatgtagatggtgggaacgccgtattagagaacatttccttctcaataagtcctggccag
agggtgggcctcttgggaagaactggatcagggaagagcactttattattggcttttttg
agactgctgaacacagaaggagaaatacaagtagatggtgtgtcttgggattcaataact
ttgcaacagtggaggaaagcttttggagtcataccccagaaagtattcatcttttctgga
acatttagaaaaaacctggatccctatggacagtggaatgatcaagaaatatggaaagtt
gcagaggaggttggactcagatctgtgatagagcagtttcctgggaagcttgattttgtc
cttgtagatgggggttgtgttctaagccacggccacaagcagttgatgtgcttggccaga
tctgttcttggtaaagcaaagatcttgctgctggatgaacccagtgctcatttggatccc
ataacgtaccaaatcattcgaagaaccctgaaacaagcatttgctgattgcacagtaatc
ctctctgaacacaggatagaagcaatgttggaatgtcaacgatttttggtcatagaggag
aacaaagtgcggcagtatgattccatccagaggctgctgagcgagaagagcctcttcagg
caggcgatcagccccttggaccgcctgaagctcctcccacaccggaactctagcaagcag
aggtctcggtccaaaatcgcagctctgaaggaggaaacagaagaagaggtgcaagaaaca
agactttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (8)   
   RefSeq(nuc) (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (17)   
   Pfam (17)   
All databases (61)   

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