KEGG T01009: 403329

Sus scrofa (pig): 403329

Entry

403329            CDS       T01009

Symbol

CYP11A1

Name

(RefSeq) cholesterol side-chain cleavage enzyme, mitochondrial precursor

K00498

cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

Organism

ssc Sus scrofa (pig)

Pathway

ssc00140

Steroid hormone biosynthesis

ssc01100

Metabolic pathways

ssc04913

Ovarian steroidogenesis

ssc04925

Aldosterone synthesis and secretion

ssc04927

Cortisol synthesis and secretion

ssc04934

Cushing syndrome

Module

ssc_M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

Brite

KEGG Orthology (KO) [BR:ssc00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    403329 (CYP11A1)
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    403329 (CYP11A1)
   04925 Aldosterone synthesis and secretion
    403329 (CYP11A1)
   04927 Cortisol synthesis and secretion
    403329 (CYP11A1)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    403329 (CYP11A1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:ssc00199]
    403329 (CYP11A1)
Enzymes [BR:ssc01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6  cholesterol monooxygenase (side-chain-cleaving)
     403329 (CYP11A1)
Cytochrome P450 [BR:ssc00199]
Cytochrome P450, animal type
  CYP11 family
   403329 (CYP11A1)

SSDB

Motif

Pfam:

p450

Other DBs

NCBI-GeneID:

403329

NCBI-ProteinID:

NP_999592

Ensembl:

ENSSSCG00000021406 ENSSSCG00000025273

UniProt:

P10612 F1D8K7

Position

7:59172829..59188479

AA seq 520 aa
MLARGLALRSVLVKGCQPFLSAPRECPGHPRVGTGEGACISTKTPRPFSEIPSPGDNGWI
NLYRFWKEKGTQKIHYHHVQNFQKYGPIYREKLGNLESVYIIDPEDVALLFKFEGPNPER
YNIPPWVAYHQHYQKPVGVLLKKSGAWKKDRLVLNTEVMAPEAIKNFIPLLDTVSQDFVG
VLHRRIKQQGSGKFSGDIREDLFRFAFESITNVIFGERLGMLEEIVDPEAQKFIDAVYQM
FHTSVPMLNLPPDLFRLFRTKTWRDHVAAWDTIFNKAEKYTQNFYWDLRRKREFNNYPGI
LYRLLGNDKLLSEDVKANVTEMLAGGVDTTSMTLQWHLYEMARSLNVQEMLREEVLNARR
QAQGDTSKMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAVYA
MGRDPAFFSNPGQFDPTRWLGKERDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE
NFKVELQHFSDVDTIFNLILMPDKPIFLVFRPFNQDPLQA

NT seq 1563 nt +upstreamnt +downstreamnt
atgctggccagggggcttgccctccgctcagtcctggtcaaaggctgccagcccttcctg
agtgcccctcgggagtgcccagggcatcccagggtgggcactggagagggagcatgcatc
tccactaaaacccctcgccccttcagtgagatcccctctcctggtgacaatggctggatt
aacctgtaccgtttctggaaggagaagggcacacagaaaatccactatcaccatgtccag
aacttccagaagtatggtcccatttacagggagaagctcggcaacttggaatctgtttat
atcatcgaccctgaagatgtggcccttctctttaagttcgaaggacccaacccagaacga
tacaacatcccgccctgggttgcctatcaccagcattaccagaagcctgttggggtcctg
ctgaagaagtcaggagcctggaagaaagaccggttggtcctgaacacggaggtaatggct
ccagaggccataaagaacttcatccccctactggacacagtgtctcaggacttcgtcggc
gtcctgcacaggcgcatcaagcagcagggttctggaaagttctcaggtgacatcagggaa
gacctgtttcgcttcgcctttgagtccatcaccaatgtcatatttggagagcgcctgggg
atgctggaggaaatagtggaccctgaggctcagaagttcattgatgctgtctaccagatg
ttccacactagtgtccccatgctcaatctcccccctgacctgttccgtctgttcaggacc
aagacctggagggaccatgtagccgcatgggacactattttcaataaagctgaaaaatac
acccagaacttctactgggacctgagacggaaaagagaatttaacaattacccaggcatc
ctctaccgcctcctgggaaatgacaagctgctctcagaagatgttaaggccaatgttacc
gagatgctggcagggggtgtagacacgacatccatgactctgcaatggcacttgtatgag
atggcacgtagcctgaatgtgcaggagatgctgcgggaggaggtcctcaatgcccggcgc
caggcccaaggagacacaagcaagatgctgcaattggtcccactcctcaaagctagcatt
aaggagacactgagactccaccccatctccgtgaccctgcagagatacctcgtgaatgac
ttggttcttcgagattacatgattcctgccaagacattggtacaagtggccgtctatgcc
atgggccgagaccccgccttcttctcaaatccaggccagtttgacccaacccggtggttg
ggtaaagaaagggacctcatccacttccggaacttgggctttggctggggcgtgcggcag
tgtgtgggccggcggatcgctgagctcgagatgactctcttcctcatccatattctggag
aacttcaaggttgaattgcagcacttcagtgatgtggacaccatattcaacctcatcctg
atgccggacaagcccatcttccttgttttccggcccttcaatcaggatccactccaggca
tga

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