KEGG   Sus scrofa (pig): 403330
Entry
403330            CDS       T01009                                 
Symbol
CYP17A1
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase precursor
  KO
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00140  Steroid hormone biosynthesis
ssc01100  Metabolic pathways
ssc04913  Ovarian steroidogenesis
ssc04917  Prolactin signaling pathway
ssc04927  Cortisol synthesis and secretion
ssc04934  Cushing syndrome
Module
ssc_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
ssc_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ssc_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ssc_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    403330 (CYP17A1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    403330 (CYP17A1)
   04917 Prolactin signaling pathway
    403330 (CYP17A1)
   04927 Cortisol synthesis and secretion
    403330 (CYP17A1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    403330 (CYP17A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:ssc00199]
    403330 (CYP17A1)
Enzymes [BR:ssc01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     403330 (CYP17A1)
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     403330 (CYP17A1)
Cytochrome P450 [BR:ssc00199]
 Cytochrome P450, animal type
  CYP17 family
   403330 (CYP17A1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 403330
NCBI-ProteinID: NP_999593
Ensembl: ENSSSCG00000010591
UniProt: P19100
Position
14:complement(113805616..113820445)
AA seq 509 aa
MWVLLVFFLLTLTYLFWPKTKGSGAKYPRSLPVLPVVGSLPFLPRRGHQHMNFFKLQDKY
GPIFSFRLGSKTTVVIGDHQLAKEVLLKKGKEFSGRPRVMTLDILSDNQKGIAFADHGTS
WQLHRKLALSTFSLFKGGNLKLENIINQEIKVLCDFLATRNGESIDLAQPLSLAMTNIVS
FICFNFSFKKGDPALQAIVNFNDGILDAVGKEILYDMFPGIRILPSQTLENMKQCVRMRN
ELLREILENRKENYSRNSITNLLDIMIQAKTNAESNTGGPDHNLKLLSDRHMLATVADIF
GAGVETSASVVKWIVAFLLHYPLLRKKIQDAIDQNIGFNRAPSISDRNQLVLLEATIREV
LRFRPVSPTLIPHRAIIDSSIGEFTIDKDTDVVVNLWALHHNEKEWLRPDLFMPERFLDP
TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFTAGLLQRFDLELPDDGQLPCLVGNP
SLVLQIDPFKVKIKERQAWKEAHTEGSTS
NT seq 1530 nt   +upstreamnt  +downstreamnt
atgtgggtgctcttggttttcttcttgctcaccctcacctatttattttggcctaagacc
aagggctctggtgccaagtaccccaggagtctcccagtcctgcccgtggtgggcagcctg
ccattcctacccagacgtggccaccagcacatgaacttcttcaagttgcaggacaaatat
ggccccatcttctcctttcgtctgggttccaagactaccgtggtaattggtgaccaccag
ctggccaaggaggtgcttctcaagaagggcaaggaattctccgggcggcccagagtgatg
actctagacatcctgtcagacaaccaaaaggggattgccttcgccgaccatggtacctcc
tggcagctgcatcggaagctggcactgagcaccttttccctgttcaagggtggcaacctg
aagctggagaacatcattaatcaagaaatcaaagtactgtgcgatttcctggccacacgg
aatggagagtccattgatttggcccagcctctctctctggcgatgaccaacatagtcagc
tttatctgcttcaacttctccttcaagaagggggatcccgcgctgcaggccatagtgaat
ttcaatgatggcatcctggatgctgtgggcaaggaaattttgtatgacatgttccctgga
attaggattttacccagccaaactctggaaaacatgaagcagtgtgttagaatgcgaaac
gaattgctgcgggaaatccttgaaaaccgtaaggagaactacagcagaaactccatcact
aacttgttggacataatgatccaagccaagacgaacgcagaaagtaacactggtggccca
gaccacaatttaaagctgctttcagacagacacatgctcgccactgttgcggacatcttt
ggggccggtgtggagacttctgcctctgtggtaaagtggatcgtggccttcctgctacac
tatcctctgctgaggaagaagatccaggatgctatcgaccagaatattggtttcaatcgt
gccccatctatcagcgaccggaaccaacttgtcctcctggaggccaccatccgagaggtg
cttcgattccggcctgtgtcccctacgctcatcccccacagggctatcattgactccagc
attggcgaatttaccattgacaaggacacagatgtcgtcgtcaatctgtgggcactgcat
cacaatgagaaggagtggctccggcccgacctgttcatgcctgagcgcttcctggacccc
acgggaacccagctcatctcaccatcattgagctacttgcccttcggagcaggaccccgc
tcttgcgtaggggagatgctagcccgccaggagctcttcctcttcacggctggattgctg
cagaggttcgacctggagctcccagatgatgggcagctaccctgtctcgtgggcaacccc
agtttggtcctgcagatagatcctttcaaagtgaagatcaaggagcgccaggcctggaag
gaagcccacactgaggggagtacctcctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (20)   
   KEGG COMPOUND (20)   
Chemical reaction (11)   
   KEGG ENZYME (2)   
   KEGG REACTION (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
Protein domain (1)   
   Pfam (1)   
All databases (76)   

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