KEGG   Sus scrofa (pig): 445539
Entry
445539            CDS       T01009                                 
Symbol
HSD3B1
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00140  Steroid hormone biosynthesis
ssc01100  Metabolic pathways
ssc04913  Ovarian steroidogenesis
ssc04925  Aldosterone synthesis and secretion
ssc04927  Cortisol synthesis and secretion
ssc04934  Cushing syndrome
Module
ssc_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
ssc_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ssc_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ssc_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    445539 (HSD3B1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    445539 (HSD3B1)
   04925 Aldosterone synthesis and secretion
    445539 (HSD3B1)
   04927 Cortisol synthesis and secretion
    445539 (HSD3B1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    445539 (HSD3B1)
Enzymes [BR:ssc01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     445539 (HSD3B1)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     445539 (HSD3B1)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 RmlD_sub_bind KR NmrA Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 445539
NCBI-ProteinID: NP_001004049
Ensembl: ENSSSCG00000006719
Vega: OTTSUSG00000000514
UniProt: Q9N119 D0G6Y4
Position
4:complement(101565229..101574110)
AA seq 373 aa
MAGWSCLVTGGGGFLGQRIVHLLLEEKDLQEIRVLDKVFKPEVREEFSKLQSKIKLTMLE
GDILDEQCLKGACQGASVVIHTASIIDVVNAVGRETVMKVNVKGTQLLLEACVQASVPVF
IHTSSIEVAGPNSYREVIQNACEEDRLETAWSAPYPLSKKLAEKAVLEANGWALQNGGTL
HTCALRPMYIYGEGSPFIFAHMNKALENNGVLTHNSKFSRVNPVYVGNVAWAHILALRAL
RDPRKALSVQGQFYYVADDTPPQSYDDLNYTLGKEWGFCLDSRRSLPPSLRYWLAFLLEI
VSFLLSPIYNYQPPFNRHFVTLCNSVFTVSYKKAQRDLGYEPLFTWEEAKQKTKAWVGSL
VKQHKEALKTKTH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggctggatggagctgccttgtgacaggaggaggagggtttctgggtcagaggatcgtc
cacttgttgctggaggagaaggatctgcaggagatccgggtactagacaaagtcttcaaa
ccagaagttcgggaggaattttctaagctccagagcaagatcaagctgaccatgctggag
ggggacatcctggatgagcagtgcctgaagggagcctgccagggggcctccgtggtcatc
cacactgcctctatcatcgacgtggtcaacgccgttgggcgagagaccgtcatgaaggtc
aatgtgaaaggtacccagctcctgctggaggcctgtgtccaggccagcgtgccggtcttc
atccacaccagcagcatagaggtggctggacccaactcctacagggaggtcatccagaac
gcctgcgaagaagaccgtctcgagacggcctggtccgcgccgtaccccttgagcaaaaag
ctggctgagaaggctgtgctggaggctaacggctgggctcttcagaacggtggtaccctg
cacacgtgtgctctgaggcccatgtatatctacggggaggggagcccattcatctttgcc
cacatgaacaaggccctggagaacaatggcgtcctgacacacaactccaagttctccaga
gtcaaccccgtctacgtcggcaacgtggcctgggcccacattctggccttgagggccctt
cgggaccccagaaaggccctcagcgtccagggacagttctactacgtcgcagacgacaca
cctccccaaagctacgatgacctcaattacacgttgggcaaggaatggggcttctgcctt
gattccagaaggagccttccgccctctctgaggtactggctggccttcctgctggaaata
gtgagcttcctgctgagtccaatttacaattatcagccccccttcaatcgccacttcgtg
accctgtgcaacagcgtgttcaccgtctcctacaagaaggcgcagcgagatctgggctac
gagccgctcttcacctgggaggaagccaagcagaaaaccaaggcgtgggttggctccctg
gtgaagcagcacaaggaggcgctgaaaaccaagactcactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (10)   
   KEGG ENZYME (2)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (16)   
   RefSeq(nuc) (2)   
   GenBank (7)   
   EMBL (7)   
Protein domain (10)   
   Pfam (10)   
All databases (82)   

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