KEGG   Sus scrofa (pig): 733694
Entry
733694            CDS       T01009                                 
Symbol
AKR1C1
Name
(RefSeq) aldo-keto reductase family 1 member C1
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00140  Steroid hormone biosynthesis
ssc00590  Arachidonic acid metabolism
ssc00790  Folate biosynthesis
ssc01100  Metabolic pathways
ssc04913  Ovarian steroidogenesis
ssc05208  Chemical carcinogenesis - reactive oxygen species
Module
ssc_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ssc_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    733694 (AKR1C1)
   00590 Arachidonic acid metabolism
    733694 (AKR1C1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    733694 (AKR1C1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    733694 (AKR1C1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    733694 (AKR1C1)
Enzymes [BR:ssc01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     733694 (AKR1C1)
    1.1.1.188  prostaglandin-F synthase
     733694 (AKR1C1)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     733694 (AKR1C1)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     733694 (AKR1C1)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 733694
NCBI-ProteinID: NP_001038083
Ensembl: ENSSSCG00000023446 ENSSSCG00000030447
UniProt: Q1KLB2
Position
10:65650223..65679878
AA seq 324 aa
MMSQMRHFSLKMNDGHTIPMLGLGTSAPSQVLKSETEMAIKRAIDIGYRHIDSAHLYQNE
EEIGRAIQMKIADGTVKRDDIFHTTKVWGTFFRPELVQTNLERSLKKLQMSYVDLYLLHH
PEALQAGEDFFPKDTHGNIIFDTVDLCTTWEAMEKCKNEGLTRSIGVSNFNCKQLERILN
KPGLKYKPVCNQVECHPYLNQSKLLEFCRSHDILLVAYATLGSDARKKWVIKNKPSLLQD
PVLNAIAEKHRRTPAQVALRYQLQRGVVALAKSFSEQRIKENFQVFEFELTPEDMESLDG
LNRNMCYLQDLFSGHTDDASYGND
NT seq 975 nt   +upstreamnt  +downstreamnt
atgatgagtcaaatgagacacttttctttaaagatgaatgatggacacaccatacctatg
ctgggattgggcacttcggctccttctcaggttcttaagagtgagacagaaatggccatc
aagagagcaatcgacataggctaccgccatattgactcagctcatttgtaccaaaatgaa
gaggaaattgggagagccattcagatgaaaattgcagatggcactgtgaagagagatgac
atcttccacactacgaaggtgtggggcacctttttccgtccagaattggtccaaactaat
ctggaaaggtcgctgaagaaacttcagatgagctatgtggatctttatctacttcatcac
ccagaagctttgcaggctggggaggactttttcccaaaggacacccatggaaacatcatt
tttgacacagtggatctctgtaccacgtgggaggccatggagaagtgcaagaacgaggga
ctgaccaggtccatcggtgtgtccaactttaactgcaagcagctggagaggatcttgaac
aagccagggctcaagtacaagcccgtctgcaaccaggtggagtgtcacccttacttaaac
cagagcaaactcctggaattctgccgttcccacgacattctccttgttgcatatgctact
ttggggtctgatgcaaggaagaaatgggtgatcaagaacaaaccaagtctcctgcaggac
ccagtactcaatgccattgctgaaaagcacaggcgaactccagcccaggttgccctgcgc
taccagctgcagcggggggtggtggccctggccaagagcttcagtgagcagaggatcaaa
gagaacttccaggtttttgaattcgagttgaccccagaggatatggaaagcctggacggc
ctaaacagaaacatgtgctatttgcaagatctattttctggtcatacagatgatgcttct
tacggcaatgattaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (6)   
   KEGG MODULE (2)   
Chemical substance (25)   
   KEGG COMPOUND (25)   
Chemical reaction (19)   
   KEGG ENZYME (4)   
   KEGG REACTION (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (2)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   RefSeq(pep) (9)   
DNA sequence (21)   
   RefSeq(nuc) (9)   
   GenBank (6)   
   EMBL (6)   
Protein domain (1)   
   Pfam (1)   
All databases (103)   

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