KEGG   Sus scrofa (pig): 751859
Entry
751859            CDS       T01009                                 
Symbol
SIRT1
Name
(RefSeq) NAD-dependent protein deacetylase sirtuin-1
  KO
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00760  Nicotinate and nicotinamide metabolism
ssc01100  Metabolic pathways
ssc04068  FoxO signaling pathway
ssc04148  Efferocytosis
ssc04152  AMPK signaling pathway
ssc04211  Longevity regulating pathway
ssc04213  Longevity regulating pathway - multiple species
ssc04218  Cellular senescence
ssc04310  Wnt signaling pathway
ssc04922  Glucagon signaling pathway
ssc04936  Alcoholic liver disease
ssc05031  Amphetamine addiction
ssc05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    751859 (SIRT1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    751859 (SIRT1)
   04068 FoxO signaling pathway
    751859 (SIRT1)
   04152 AMPK signaling pathway
    751859 (SIRT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    751859 (SIRT1)
  09143 Cell growth and death
   04218 Cellular senescence
    751859 (SIRT1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    751859 (SIRT1)
  09149 Aging
   04211 Longevity regulating pathway
    751859 (SIRT1)
   04213 Longevity regulating pathway - multiple species
    751859 (SIRT1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    751859 (SIRT1)
  09165 Substance dependence
   05031 Amphetamine addiction
    751859 (SIRT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    751859 (SIRT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ssc03036]
    751859 (SIRT1)
   03029 Mitochondrial biogenesis [BR:ssc03029]
    751859 (SIRT1)
Enzymes [BR:ssc01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     751859 (SIRT1)
Chromosome and associated proteins [BR:ssc03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     751859 (SIRT1)
Mitochondrial biogenesis [BR:ssc03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    751859 (SIRT1)
SSDB
Motif
Pfam: SIR2 DUF592
Other DBs
NCBI-GeneID: 751859
NCBI-ProteinID: NP_001139222
UniProt: A0A4X1TRZ2 A7LKB1
Position
14:71091167..71126351
AA seq 742 aa
MADEAALALQPGGSPSAVAAEREAPSPPAGEPLRKKPRRDGPGVGRSPGEPGGAALEREL
PAAAGGCPAAAVLWRETAAGGEREAQAAAAAGEGNNGPGLQGLSREAPPADDFYDDDDDD
EGEEEEEAAAAAAIGYRDNLLFGDEIVTNGFHSCESDEDDRASHASSSDWTPRPRIGPYT
FVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDA
VKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDP
RPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSF
ATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAM
KYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVII
NELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAHLSELPPTPLNISEGSSSPERTSP
PASSVTLPLLDQATKSNVDDLDVSESKDCVEEKSQEVQTSRSIESVKEPMESPGLKNVAC
SNGEKNERTSVAETVRKCWPARLAKEQISKRLDGNQYLFLPPNRYIFHGAEVYSDSEDDV
LSSSSCGSNSESGTCQSPSLEEPMEDESEIEEFYNGLEDDADVNMRAGGTGFGADGSDQE
AVNEAISMKQEATGVNYPSNKS
NT seq 2229 nt   +upstreamnt  +downstreamnt
atggcggacgaggcggcgctcgcccttcagcccggcggctccccctcggcggtggcggct
gagagggaggccccgtcgccccccgccggggagccgctccgcaagaaaccgcggagagac
ggcccgggcgtcgggcggagcccgggcgagcctggtggggcggccttggagcgtgagctg
ccggcggcggcgggcggctgcccggcggcggcggtgctgtggcgggagaccgctgcgggc
ggggagcgggaggcccaggcggctgcggcggcaggagaaggaaacaatgggccgggctta
cagggcctatcccgggaggcgcccccggccgacgacttctacgacgacgacgacgacgac
gagggcgaggaggaggaagaggcggcggcagcggcggctattgggtaccgagataacctt
ctgtttggtgatgaaatcgtcaccaatggtttccattcttgtgaaagtgatgaggatgat
agagcctcacatgccagttctagtgactggactccaagaccacggataggtccatatact
tttgttcagcaacatctcatgattggcacagatcctcgaacaattcttaaagatttgcta
ccagaaacaattcctccacctgaattggatgatatgacactgtggcagattgttattaat
atcctttcagaaccaccaaaaaggaaaaaaagaaaagatattaatacaattgaagatgct
gtgaaattactacaagagtgcaaaaaaataatagttctaactggagctggggtttctgtt
tcttgtggaatacctgacttcaggtcaagagatggcatttatgcacgccttgcagtagac
tttccagaccttcctgatcctcaagcaatgtttgatattgaatatttcagaaaagatcca
agaccattcttcaagtttgcaaaggaaatatatcctggacagttccagccatctctctgt
cacaaattcatagccttgtcagataaggaaggaaaactgcttcgcaactatactcagaac
atagatacactggaacaggttgcaggaatccagaggataatccagtgtcatggttccttt
gcaacagcatcttgcctgatttgtaaatataaagttgactgtgaagctgtacgaggagat
atttttaatcaggtggttcctcgatgtcctaggtgcccagctgatgaaccacttgctatc
atgaaaccagagattgtcttttttggtgaaaatttaccagagcagtttcatagagccatg
aagtatgacaaagatgaagttgatcttctcattgttattgggtcttccctgaaagtaaga
ccagtagcactaattccaagttccataccccatgaagtgcctcagatattaattaatagg
gaacctttgcctcacctgcattttgatgtagagcttcttggagactgtgatgtcattatt
aatgaattgtgtcataggttaggaggtgaatatgccaagctttgctgcaaccctgtaaag
ctttcagaaattactgaaaagcctccacgaacacaaaaagagttggctcacttgtcagag
ttaccacccacacctcttaatatttcagaaggctctagttcaccagaaagaacttcacca
ccagcttcttcagtgactctccctcttttagaccaagcaacaaagagtaatgttgatgat
ctagatgtgtctgagtcaaaagactgtgttgaagagaaatcacaggaagtacagacttct
aggagcattgaaagtgttaaagaaccgatggagagtccaggtttgaagaatgttgcctgc
agtaatggagagaaaaatgaaagaacttcagttgccgaaacagtaagaaaatgctggcca
gctagacttgcaaaggagcagattagtaaacggcttgatggtaatcagtatctgttttta
ccaccaaaccgttatattttccatggcgctgaggtatattcagactctgaagatgatgtc
ttatcctctagttcttgtggcagtaacagtgagagtggaacttgccagagtccaagtcta
gaagaacccatggaggatgaaagtgagattgaagaattttacaatggtttggaagatgat
gctgatgttaatatgcgagctggaggaactggatttggagctgatggaagtgaccaagag
gcagttaatgaagctatatccatgaaacaggaagcaacaggcgttaactatccatcaaac
aaatcataa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (13)   
   KEGG PATHWAY (13)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (2)   
   Pfam (2)   
All databases (64)   

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