KEGG   Sus scrofa (pig): 780403
Entry
780403            CDS       T01009                                 
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc05012  Parkinson disease
ssc05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    780403 (LRRK2)
   05022 Pathways of neurodegeneration - multiple diseases
    780403 (LRRK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssc01001]
    780403 (LRRK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ssc04131]
    780403 (LRRK2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ssc04147]
    780403 (LRRK2)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     780403 (LRRK2)
Protein kinases [BR:ssc01001]
 Serine/threonine kinases: TKL group
  LRRK family
   780403 (LRRK2)
Membrane trafficking [BR:ssc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    780403 (LRRK2)
Exosome [BR:ssc04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   780403 (LRRK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr LRR_8 Roc LRR_4 COR Ras LRR_9 Arf WD40_2 Ank_2 nSTAND3 T2SSE AAA_22 LRR_6 AAA_16 ABC_tran Kdo G-alpha MMR_HSR1 NACHT PduV-EutP AAA_7 GTP_EFTU TrwB_AAD_bind MobB AAA_29 cobW FtsK_SpoIIIE Arm TniB AAA_23
Other DBs
NCBI-GeneID: 780403
NCBI-ProteinID: NP_001106908
Ensembl: ENSSSCG00000000784
UniProt: A9XXE0
Position
5:71800337..71945828
AA seq 2526 aa
MASGSCQGCEEEDEEALKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASRLFQDKN
VHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGHDWEALGIHQLIL
KMLTVHNASVSLSTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYVILLSALKKFKDEEEIVLHVLHCLHSLAIPCSNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHAFVVRAV
QQYSENAVLQIAALSSLALLTETIFLNQDLEEKNENQENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDTM
AAVAPKIITVMKSHETSLSVQLEALRAILHFIVPDITEESREDTEYQHKLNMVKKQCFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSLAYFPDALEVLSPEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLVTKKNLCLGTGHLLAKILISSLQRFKDIGEVQIKGFQTILTILEMSV
SFSKLLVNHSFDSVIFHQMSSGMEQKDQQFLNLCCKCFAIVAMDDELKSVMLERACDQNN
SIMVECLLLLGADVNCAKEATSLIYQVCEKASSPKLVELLLNSGSREQDVRKALTISIGK
GDSQVISLLLRRLALDLANNSICLGGFCMGKIEPSWLGPLFPDKTSNLRKETNVGSTLAR
MVLRYQMKSAVEEGAASGSRRNLSEEILDKFDEWTFIPDSYVDSVFGQSDDLDSEGSEGS
FLVKKKANSISVGEFYRDAALQRCSPNLQRHSNSLGPMVDYEDLLKRKRKILSSDDSLRT
SKLQSHVRHSDSVSSLASERENITSLDLSANELKDIDALSQKSCISGHLEHLEKLELHQN
ALTSFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDIGPSVVLDPAVK
CPTLKQFNLSYNQLSSLPENLSDVVEKLEQLILEGNKISGVCLPLSLKELKILNLSKNRI
SSFSEDFLEACPQVESLSARMNFLAAMPFLPSSMTSLKLSQNRFTCVPEAILNLPHLRSL
DMSSNDIKYLPGPVHWRSMNLRELLFSHNQISTLDLSEKACAWSRVEKLHLSHNKLKEIP
PEIGCLENLTSLDVSCNLELRSFPNEMGKLSKIWDLPLDDLHLNFDFKHIGCKAKDIIRF
LQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMRIKKSDLGMQGATVGIDVKDWPIQIR
GKRKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKAR
ASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKLR
KTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKEYQ
LQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGCPKY
PKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPTGEEYLLVPSSLSDHRPVIE
LPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLN
WSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDIC
GEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEGGDLLVNPDQPRLTIPISQIAPDLTL
ADLPRNIMLNSDELKFEQAPEFLLGDGSFGSVYRATYEGEEVAVKIFNKHTSLRLLRQEL
VVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADG
LRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAP
EVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYGC
APWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRRMSIPKNFIVECMVASNHN
SKNASVWLGCGHTDKGQLSFLDLNTERYTSEEVTDSRILCLALVHLPLEKESWIVSGTQS
GVLLVINTEDGRKRHTLEKMTDSVTCLYCNSFSKPSKQKNFLLVGTADGNLAVFEDKSVK
CKGAAPLKILSIGNVSTPLMCLSESMNLTEKNIMWGGCGTKVFSFSDDFTIQKLIETRTN
QLFSYASFSDSNIIAVVVDTALYIAKKNSPFVEVRDKKTEKLCELIDCVHFLKEELAKAN
KELKHKLSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIMRIIHNFCDSVRAMMTT
QLGSLKNVMLVLGYNRKSAEGIQHQKEIESCLSIWDINLPHEVQNLEKHIEVRKELAEKM
RRISVE
NT seq 7581 nt   +upstreamnt  +downstreamnt
atggccagtggcagctgccaggggtgcgaggaggaggacgaagaagctctgaagaaactg
atagtcaggctgaacaatgtccaagaaggaaaacagatagagacgctggtccaaatcctg
gaggatatgctggtgttcacttacgccgaccacgcctccaggttatttcaagacaaaaat
gtccacgtgcctctgttgatcgtcttggactcgtatatgagagtcgctagtgtgcagcag
gtgggttggtcacttttatgcaaattaatagaaatctgtccaaatacaatgcaaagctta
atgggaccccaggatattggacatgattgggaagcccttgggattcaccaactgattctt
aaaatgctcacagttcataatgccagtgtcagcctgtcaacagttggattgaaggcctta
gatcttctcctaacttcaggtaaaatcactttgctgatactggatgaagaaagcgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgatgaagtccagaaactt
ggatgcaaagctttacatgtgctgtttgagagagtttcagaggagcaactgactgaattt
gttgagaacaaagattacgtgatcttgctgagtgcattaaagaagtttaaagatgaagag
gaaattgtgcttcatgtactgcactgtttacattccctagcaattccttgcagtaatgtt
gaagtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgaaagca
ttccctgtcaatgagaaaattcaagaagtgagttgttgcttgctccatagacttacatta
ggtaatttttttaatatcctggtattaaacgaggtgcatgcatttgtggtgagagctgta
cagcagtattccgagaatgcagtcctgcaaatcgcagcactcagctctttagctctcctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatcaagaaaatgat
gatgaggaagaagataaattgttttggctggaagcctgttacaaagcattaacgtggcat
aggaagaacaagcacgtgcaggaggctgcatgctgggccctaaacaatctccttatgtac
cagaacagtttacatgagaagattggagatgaagatggccagttcccagcccacagggaa
gtgatgctgtccatgctgatgcactcttcatcgaaagaagtcttccaggcatctgcaaat
gctttgtcaactctgttagaacaaaacgttaatttcagaaaaatcctgttgtcaaaagga
atatatctaaatgtattggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaaccatctctttgagggaagtaacacttccctggatacaatg
gcagcagtggcccccaaaataataacagttatgaagagtcatgagacatcattatcagtg
cagctggaggcacttcgagctattttacattttatagttccagacatcacagaagaatcc
agggaagatactgaatatcaacataaactaaatatggtgaaaaaacagtgtttcaggaat
gatattcacaaattggtcctggcggctttgaacaggttcattggaaatccagggattcag
aaatgcggattaaaagtaatttcttctctagcatattttcctgatgcgttagaagtatta
tccccggaaggtgctattgattctgtgcttcacacgctgcagatgtatccagacgaccaa
gaaattcagtgtctgggtttaagtcttataggatgcttggttacaaagaagaacttatgc
ctaggaactggacatctgctggcaaaaattttgatttccagtttacagcggtttaaggac
attggtgaagtacagattaaaggatttcagacaattttgacaatactggaaatgtcagtg
tctttttccaagctgctggtgaatcattcctttgattcagtaattttccatcagatgtcc
tctggtatggagcaaaaggatcaacagtttctaaacctttgttgtaagtgctttgcaata
gtggctatggacgatgagttgaaaagtgtgatgctggagagagcatgtgatcagaataac
agcatcatggtcgaatgcttgcttttattgggagcggatgtcaattgtgcaaaagaggca
acttctttaatttatcaggtatgtgagaaagcaagtagtcccaaactggtggaactgtta
ctgaatagtggatcccgtgagcaagatgtacggaaagctttgacaatcagcattggaaaa
ggcgacagccaagtcatcagcttactcttaaggaggctcgccttggatctggccaataat
agcatatgtcttggaggattttgtatgggaaaaatcgaaccttcttggcttggtccttta
tttccagataagacatctaatttaagaaaagaaacaaatgtaggatccaccctagctaga
atggtgcttagatatcagatgaaaagtgctgtggaagaaggagccgcttcaggcagcaga
aggaatctttctgaagaaatacttgataaatttgatgaatggacctttattcctgactct
tatgtggatagtgtgtttggtcaaagtgatgacctagatagtgaaggaagtgaaggctca
tttcttgtgaaaaagaaagcaaattcaatcagtgtaggagagttttaccgagatgctgcc
ttgcagcgttgctcaccaaatttgcaaagacattccaattcattgggacccatggttgat
tatgaagatttgctgaagagaaaaagaaagatactatcttcagatgactcactcagaaca
tcaaaactccaatcacatgtgaggcattcagacagcgtttcttccttggcttctgagaga
gaaaacattacatcattagacctctcagcgaatgaactaaaagatattgatgccctgagc
cagaaatcctgcatcagtggtcatttggagcatcttgaaaagctggagcttcaccagaat
gcactcacgagcttcccacaacagctatgtgaaactctgaagtgtttgacacatttggac
ttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgaactgtattgcc
aaccttgatgtctctcgaaatgacattgggccctctgtggttttggatcctgctgtgaag
tgcccgaccttgaaacagtttaacctgtcctacaatcagctgtcttctcttcctgagaac
ctcagtgatgtggtagagaaactggaacagctcattttagaaggaaataaaatatcagga
gtatgtttgcctttgagcctgaaggaactgaagattttaaaccttagtaagaaccgcatt
tcatctttctcagaggactttcttgaggcttgtcctcaagtggagagtttaagtgccaga
atgaattttcttgctgctatgccatttttgccttcatccatgacaagcctaaaattatct
caaaacagatttacatgtgttccagaagcaattttaaatcttccacacctacggtcctta
gacatgagcagcaatgatattaaatatctaccaggtcctgtgcactggagatctatgaac
ttaagggaactcttgtttagtcataatcagatcagtaccttggacttgagtgaaaaagca
tgtgcatggtctagagtagagaaactacatctttctcataataaactgaaagagattcct
cctgagattggctgtcttgaaaatctgacatcgcttgatgttagttgcaacttggaactg
agatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggatgat
ctgcatcttaattttgattttaaacatataggatgtaaagccaaagacatcataaggttt
cttcaacagcggttaaaaaaggctgtgccctataatcgaatgaaacttatgatagtggga
aacactgggagtggtaaaaccaccttattacagcaattaatgagaatcaagaaatcagat
cttggtatgcaaggtgccacagttggcatagatgtgaaggactggcccatccaaataaga
ggcaaaaggaagaaagacctcattctaaatgtgtgggattttgcaggtcgtgaggagttc
tacagcacccatccccactttatgacccagcgagctctgtaccttgctgtctatgaccta
agcaaagggcaagctgaagttgatgccatgaagccttggctcttcaatataaaggctcgt
gcttcttcttcccctgtgattcttgttggcacacatttggatgtttctgatgagaagcag
cgcaaagcctgtataagtaaaatcaccaaggaactcttgaacaaacgcgggtttcctgca
atccgggattaccactttgtaaatgccaccgaggaatcagatgctttggcaaaacttcgg
aaaaccatcataaatgagagcctcaatttcaagatccgagatcagcctgttgttgggcag
ctgattccagactgctatgtagaacttgagaaaatcattttatcagagcgtaaaaatgtg
ccaattgaatttcctgtaattgaccggaaacgattattacaactcgtgaaagaatatcag
ctgcagttagacgaaaatgagcttccgcatgcagttcacttcctaaatgaatcaggtgtc
cttcttcattttcaagacccagcgctgcagttaagtgacttatattttgtggaacccaag
tggctttgtaaagtcatggcgcagattttgacagtgaaagtggaaggctgtccaaaatat
cctaagggaattatttcccgtagagatgtggaaaaatttctttcaaagaaaaagagattt
ccgaagaactacatgtcacagtactttaaacttctagaaaaattccagattgccttgcca
acaggagaagaatatttgctggttccaagcagcttgtctgaccacaggcctgtgatagag
cttcctcactgtgagaactctgaaattatcattcgactctatgaaatgccttattttcca
atgggcttttggtcaagattaatcaatcgattacttgaaatttcaccctacatgctttca
ggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttgaat
tggtctcctgaagcttattgcctggtaggatctgaagtcttagacaatcaccctgagagt
ttcttaaaaattacagttccttcttgtcgaaaaggctgtattcttttgggccaagttgtg
gaccacattgattctctcatggaagagtggtttccggggttactggagattgatatttgt
ggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaagag
catcaaaaaatcttacttgacgacttgatgaagaaagcagaaggaggagaccttctagta
aatccagatcaaccaaggctcactattccaatatctcagattgcccctgacttgactttg
gctgacctgcctagaaatattatgttgaatagtgatgaactgaaatttgaacaagctccc
gagtttctcttaggtgatgggagttttggatctgtttatcgagcaacctatgaaggagaa
gaagtggctgtgaagatttttaataaacatacgtcacttagactgttacgacaggagctg
gtggtactttgccacctccatcaccccagcttaatatctttgctggcggctgggattcgt
cctcggatgttggtgatggaactcgcctccaagggttcactggatcgcctgcttcagcaa
gacaaagccagtctcaccagaacactgcagcacaggatcgcgctccacgtggccgatggc
ttgagataccttcactcagccatgattatataccgtgacttgaagccccacaacgtgttg
cttttcaccctgtatcccaatgctgccatcatcgccaagattgctgactatgggattgct
cagtactgctgtagaatggggataaaaacgtcagagggcacaccagggtttcgtgcacct
gaagttgctagaggaaatgttatttataaccaacaggctgatgtttattcatttggtttg
ctactctatgacattttgacaactggaggtagaatagcagagggtttgaagtttccaaat
gagtttgatgaactggcaatacaaggaaaattacctgatccagttaaggaatatggttgt
gccccatggcctatggttgagaagttaattaaaaagtgtttaaaagaaaatcctcaagaa
agacctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctgatg
agacgtatgtcaatacctaaaaacttcattgtcgaatgcatggttgcctcgaatcataac
agcaagaacgcaagcgtttggctgggctgtgggcacactgacaaaggacagctctcattt
cttgacttaaatacggaaagatatacttctgaggaagttactgatagcagaatactgtgc
ttagccttggtgcatcttcctcttgaaaaggaaagctggattgtgtctggaacacagtct
ggtgtgctcctcgtcatcaatactgaagatgggagaaagaggcacaccctggaaaagatg
accgactctgttacttgcttgtattgcaattccttttccaagcctagcaagcaaaaaaat
ttccttttagtgggaactgctgacggcaacttagcagtttttgaagataaaagtgttaag
tgtaaaggagctgctcctttgaagatactcagcataggaaatgtcagtactccactgatg
tgtttgagtgaatccatgaatttaactgaaaaaaacattatgtggggaggatgtggtaca
aaagttttctcgttttctgatgacttcaccattcagaaactcatcgagaccaggacaaat
caactgttttcttatgcatctttcagtgactccaacatcatagcagtggtggtagacaca
gctctttacattgctaagaaaaatagcccttttgtggaagttcgtgacaagaagactgaa
aaactctgtgaactaatagactgtgtgcactttttaaaggaggaactggccaaagcaaac
aaggaattgaaacacaaactgtcttattctgggagagtgaaaactctctgcctccagaag
aacactgctctctggataggaactggtggaggccatatcttactccttgatctttcaact
cgtcgaattatgcgtataattcacaacttctgcgattctgtcagagccatgatgaccaca
cagttaggaagccttaaaaatgtcatgctggttttggggtataaccggaaaagtgctgaa
ggtattcaacaccaaaaagagatagagtcttgcctgtctatttgggacatcaatcttcca
catgaagtacaaaatttggaaaaacatattgaagtgagaaaagaattagctgaaaaaatg
agaagaatatctgttgaataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (32)   
   Pfam (32)   
All databases (77)   

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