+F Repair protein KO
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DNA Repair and Recombination Proteins - Heterocephalus glaber (naked mole-rat)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 101714788 Mgmt; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 101716220 Alkbh2; alkB homolog 2, alpha-ketoglutarate dependent dioxygenase K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 101716978 Alkbh3; alkB homolog 3, alpha-ketoglutaratedependent dioxygenase K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 101710759 Ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 101717051 Ung; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 101725531 Ccno; cyclin O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101703457 Tdg; thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 101707491 Mpg; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 101709636 Smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 101706875 Mutyh; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 101724783 Mbd4; methyl-CpG binding domain 4, DNA glycosylase K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 101697522 Ogg1; 8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 101717092 Neil1; nei like DNA glycosylase 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 101708646 Neil2; nei like DNA glycosylase 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 101721261 Neil3; nei like DNA glycosylase 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 101717895 Nthl1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 101709711 Apex1; apurinic/apyrimidinic endodeoxyribonuclease 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 101701150 Apex2; apurinic/apyrimidinic endodeoxyribonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 101699680 Pold1; DNA polymerase delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 101722261 Pold2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
F 101708160 Pold3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
F 101706646 Pold4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 101720520 Pole; DNA polymerase epsilon, catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 101705066 Pole2; DNA polymerase epsilon 2, accessory subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 101701491 Pole3; DNA polymerase epsilon 3, accessory subunit K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 101721926 Pole4; DNA polymerase epsilon 4, accessory subunit K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
F 101711731 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 101714005 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 101698770 Fen1; flap structure-specific endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101702301 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 101710722 Polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 101701146 Xrcc1; X-ray repair cross complementing 1 K10803 XRCC1; DNA-repair protein XRCC1
E 101701011 Lig3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 101712310 Tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 101719882 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101704813 Aplf; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 101712591 Pnkp; polynucleotide kinase 3'-phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 101705428 Hmgb1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 101696600 Poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 101703207 Parp1; poly(ADP-ribose) polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 101725931 Parp3; poly(ADP-ribose) polymerase family member 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 101715258 Parp4; poly(ADP-ribose) polymerase family member 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 101704782 Parp2; poly(ADP-ribose) polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 101707002 Xpc; XPC complex subunit, DNA damage recognition and repair factor K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 101696493 Rad23b; RAD23 homolog B, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 101719617 Rad23a; RAD23 homolog A, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 101715233 Cetn2; centrin 2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 101712475 Rbx1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 101711205 Cul4b; cullin 4B K10609 CUL4; cullin 4
F 101703310 Cul4a; cullin 4A K10609 CUL4; cullin 4
F 101712635 Ddb1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 101715591 Ddb2; damage specific DNA binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 101725588 Polr2a; RNA polymerase II subunit A K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 101716957 Polr2b; RNA polymerase II subunit B K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 101725624 Polr2c; RNA polymerase II subunit C K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 101703872 Polr2d; RNA polymerase II subunit D K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 101709249 Polr2e; RNA polymerase II subunit E K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 101714368 Polr2f; RNA polymerase II subunit F K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 101697518 Polr2g; RNA polymerase II subunit G K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 101706663 Polr2h; RNA polymerase II subunit H K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 101713641 Polr2i; RNA polymerase II subunit I K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 101723718 Polr2l; RNA polymerase II subunit L K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 101721550 Polr2j; RNA polymerase II subunit J K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 101718217 Polr2k; RNA polymerase II subunit K K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 101712475 Rbx1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 101711205 Cul4b; cullin 4B K10609 CUL4; cullin 4
F 101703310 Cul4a; cullin 4A K10609 CUL4; cullin 4
F 101712635 Ddb1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 101724861 Ercc8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 101712293 Ercc6; ERCC excision repair 6, chromatin remodeling factor K10841 ERCC6; DNA excision repair protein ERCC-6
F 101719940 Uvssa; UV stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 101717517 Elof1; elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 101725837 Ercc3; ERCC excision repair 3, TFIIH core complex helicase subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 101697378 Ercc2; ERCC excision repair 2, TFIIH core complex helicase subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 101713708 Gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 101705678 Gtf2h2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 101699661 Gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 101698842 Gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 101699974 Gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 101702664 Cdk7; cyclin dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 101714118 Ccnh; cyclin H K06634 CCNH; cyclin H
E 101718839 Mnat1; MNAT1, CDK activating kinase assembly factor K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 101698906 Rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 101708546 Rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 101708155 Rpa3; replication protein A3 K10740 RPA3; replication factor A3
E 106008038 Rpa4; replication protein A4 K10741 RPA4; replication factor A4
D Other NER factors
E 101726488 Xpa; XPA, DNA damage recognition and repair factor K10847 XPA; DNA-repair protein complementing XP-A cells
E 101699727 Ercc1; ERCC excision repair 1, endonuclease non-catalytic subunit K10849 ERCC1; DNA excision repair protein ERCC-1
E 101717694 Ercc4; ERCC excision repair 4, endonuclease catalytic subunit K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 101723410 Ercc5; ERCC excision repair 5, endonuclease K10846 ERCC5; DNA excision repair protein ERCC-5
E 101702301 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 101726454 Mms19; MMS19 homolog, cytosolic iron-sulfur assembly component K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 101726360 Cul3; cullin 3 K03869 CUL3; cullin 3
E 101709314 Cul5; cullin 5 K10612 CUL5; cullin 5
E 101723674 Eloc; elongin C K03872 ELOC; elongin-C
E 101715777 Elob; elongin B K03873 ELOB; elongin-B
E 101713591 Eloa; elongin A K15076 ELOA; elongin-A
E 101696880 Ubap2l; ubiquitin associated protein 2 like K26545 UBAP2; ubiquitin-associated protein 2
E 101711472 Ubap2; ubiquitin associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 101706924 Msh2; mutS homolog 2 K08735 MSH2; DNA mismatch repair protein MSH2
E 101700364 Msh3; mutS homolog 3 K08736 MSH3; DNA mismatch repair protein MSH3
E 101708261 Msh6; mutS homolog 6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 101698546 Mlh1; mutL homolog 1 K08734 MLH1; DNA mismatch repair protein MLH1
E 101712682 Pms2; PMS1 homolog 2, mismatch repair system component K10858 PMS2; DNA mismatch repair protein PMS2
E 101723287 Mlh3; mutL homolog 3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 101699680 Pold1; DNA polymerase delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 101722261 Pold2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
E 101708160 Pold3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
E 101706646 Pold4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 101698906 Rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 101708546 Rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 101708155 Rpa3; replication protein A3 K10740 RPA3; replication factor A3
E 106008038 Rpa4; replication protein A4 K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 101697246 Rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 101697046 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 101719049 Rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 101710167 Rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 101723031 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 101714005 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 106007500 Exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 101705428 Hmgb1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 101702301 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 101697052 Wdr76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 101709211 Mre11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 101719180 Rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 101708611 Nbn; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 101705460 Brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101722439 Bard1; BRCA1 associated RING domain 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 101705460 Brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101722678 Fam175a; family with sequence similarity 175 member A K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 101703646 Uimc1; ubiquitin interaction motif containing 1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 101720805 Babam1; BRISC and BRCA1 A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 101696560 Bre; brain and reproductive organ-expressed (TNFRSF1A modulator) K12173 BRE; BRCA1-A complex subunit BRE
E 101719523 Brcc3; BRCA1/BRCA2-containing complex subunit 3 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 101705460 Brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101716733 Brip1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 101717100 Topbp1; topoisomerase (DNA) II binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 101705460 Brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101713602 Rbbp8; RB binding protein 8, endonuclease K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 101709211 Mre11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 101719180 Rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 101708611 Nbn; nibrin K10867 NBN; nibrin
D BRCA complex
E 101705460 Brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101698015 Brca2; BRCA2, DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 101720121 Palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 101715048 Rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 101715048 Rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 101714221 Rad51b; RAD51 paralog B K10869 RAD51L1; RAD51-like protein 1
E 101714867 Rad51c; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 101704106 Rad51d; RAD51 paralog D K10871 RAD51L3; RAD51-like protein 3
E 101697422 Xrcc2; X-ray repair cross complementing 2 K10879 XRCC2; DNA-repair protein XRCC2
E 101699387 Xrcc3; X-ray repair cross complementing 3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 101706789 Rad52; RAD52 homolog, DNA repair protein K10873 RAD52; DNA repair and recombination protein RAD52
E 101720601 Rdm1; RAD52 motif containing 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 101719853 Rad54l; RAD54-like (S. cerevisiae) K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 101721867 Rad54l2; RAD54-like 2 (S. cerevisiae) K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 101697859 Rad54b; RAD54 homolog B (S. cerevisiae) K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 101701240 Recql; RecQ like helicase K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 101701103 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 101724469 Wrn; Werner syndrome RecQ like helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 101719260 Blm; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101710862 Recql4; RecQ like helicase 4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 101724970 Recql5; RecQ like helicase 5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 101719260 Blm; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101708161 Top3b; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101706019 Top3a; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101718524 Rmi1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 101724407 Rmi2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 101698906 Rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 101708546 Rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 101708155 Rpa3; replication protein A3 K10740 RPA3; replication factor A3
E 106008038 Rpa4; replication protein A4 K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 101701412 Ppp4c; protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 101710030 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 101718351 Ppp4r1; protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 101726544 Ppp4r2; protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 101710488 Ppp4r3a; protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101706954 serine/threonine-protein phosphatase 4 regulatory subunit 3B-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101706307 serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101706981 Ppp4r3b; protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101708472 Ppp4r4; protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 101714752 Ap5b1; adaptor related protein complex 5 beta 1 subunit K19022 AP5B1; AP-5 complex subunit beta-1
E 101697870 Ap5m1; adaptor related protein complex 5 mu 1 subunit K19023 AP5M1; AP-5 complex subunit mu-1
E 101702372 Ap5s1; adaptor related protein complex 5 sigma 1 subunit K19024 AP5S1; AP-5 complex subunit sigma-1
E 101724730 Ap5z1; adaptor related protein complex 5 zeta 1 subunit K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 101715146 Smc5; structural maintenance of chromosomes 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 101718055 Smc6; structural maintenance of chromosomes 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 101719602 Fam84a; family with sequence similarity 84 member A K22805 FAM84A; protein FAM84A
E 101703770 Nsmce1; NSE1 homolog, SMC5-SMC6 complex component K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 101707405 Nsmce2; NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 101725921 Nsmce3; NSE3 homolog, SMC5-SMC6 complex component K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 101705968 Nsmce4a; NSE4 homolog A, SMC5-SMC6 complex component K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 101700021 Eid3; EP300 interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 101726345 Slf1; SMC5-SMC6 complex localization factor 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 101717634 Slf2; SMC5-SMC6 complex localization factor 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 101705463 Eme1; essential meiotic structure-specific endonuclease 1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 101697749 Eme2; essential meiotic structure-specific endonuclease subunit 2 K10883 EME2; crossover junction endonuclease EME2
E 101710627 Exd2; exonuclease 3'-5' domain containing 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 101711801 Mus81; MUS81 structure-specific endonuclease subunit K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 101701840 Swi5; SWI5 homologous recombination repair protein K10991 SWI5; DNA repair protein Swi5/Sae3
E 101710423 Sfr1; SWI5 dependent homologous recombination repair protein 1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 101696787 Slx1a; SLX1 homolog A, structure-specific endonuclease subunit K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 101709821 Slx4; SLX4 structure-specific endonuclease subunit K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 101716898 Gen1; GEN1, Holliday junction 5' flap endonuclease K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 101701583 Spg11; spastic paraplegia 11 (autosomal recessive) K19026 SPG11; spatacsin
E 101714566 Zfyve26; zinc finger FYVE-type containing 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 101724311 Rad51ap1; RAD51 associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 101700945 Morf4l1; mortality factor 4 like 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 101709493 Samhd1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 101698918 Fignl1; fidgetin like 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 101724483 Spidr; scaffolding protein involved in DNA repair K22806 SPIDR; DNA repair-scaffolding protein
E 106008379 DNA repair-scaffolding protein-like K22806 SPIDR; DNA repair-scaffolding protein
E 101705713 Fam84b; family with sequence similarity 84 member B K22810 FAM84B; protein FAM84B
E 101698169 Brat1; BRCA1 associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 101724160 CUNH21orf2; chromosome unknown C21orf2 homolog K23456 CFAP410; cilla- and flagella-associated protein
E 101696481 hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 101708434 Zswim7; zinc finger SWIM-type containing 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 101710304 Swsap1; SWIM-type zinc finger 7 associated protein 1 K25771 SWSAP1; ATPase SWSAP1
E 101725120 Emsy; EMSY, BRCA2 interacting transcriptional repressor K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 101700246 Hsf2bp; heat shock transcription factor 2 binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 101718280 Mms22l; MMS22 like, DNA repair protein K26125 MMS22L; protein MMS22-like
E 101717364 Tonsl; tonsoku-like, DNA repair protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 101725647 Bod1l1; biorientation of chromosomes in cell division 1 like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 101708284 Parpbp; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 101703462 Xrcc6; X-ray repair cross complementing 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 101719341 Xrcc5; X-ray repair cross complementing 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 101722248 Prkdc; protein kinase, DNA-activated, catalytic polypeptide K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 101709211 Mre11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 101719180 Rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 101722009 Lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 101709691 Xrcc4; X-ray repair cross complementing 4 K10886 XRCC4; DNA-repair protein XRCC4
E 101726729 Nhej1; non-homologous end joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 101696600 Poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 101722951 Polm; DNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 101718847 Dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 101710722 Polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 101719882 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101704813 Aplf; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 101700859 Dclre1c; DNA cross-link repair 1C K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 101721465 Tdp2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 101725927 Smchd1; structural maintenance of chromosomes flexible hinge domain containing 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 101699772 Mum1l1; MUM1 like 1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 101703228 PWWP domain-containing protein MUM1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 101698476 chromosome unknown open reading frame, human C9orf142 K25772 PAXX; protein PAXX
E 101708548 chromosome unknown open reading frame, human C7orf49 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 101702567 Jmjd8; jumonji domain containing 8 K25792 JMJD8; jumonji domain-containing protein 8
E 101717821 chromosome unknown open reading frame, human C20orf196 K26128 SHLD1; shieldin complex subunit 1
E 101697602 Fam35a; family with sequence similarity 35 member A K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 101700504 Fanca; Fanconi anemia complementation group A K10888 FANCA; fanconi anemia group A protein
E 101721282 Fancb; Fanconi anemia complementation group B K10889 FANCB; fanconi anemia group B protein
E 101710421 Fancc; Fanconi anemia complementation group C K10890 FANCC; fanconi anemia group C protein
E 101721106 Fance; Fanconi anemia complementation group E K10892 FANCE; fanconi anemia group E protein
E 101714180 Fancf; Fanconi anemia complementation group F K10893 FANCF; fanconi anemia group F protein
E 101712516 Fancg; Fanconi anemia complementation group G K10894 FANCG; fanconi anemia group G protein
E 101702870 Fancl; Fanconi anemia complementation group L K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 101713730 Fancm; Fanconi anemia complementation group M K10896 FANCM; fanconi anemia group M protein
E 101721419 Faap24; Fanconi anemia core complex associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 101703438 Faap100; Fanconi anemia core complex associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 101697897 Hes1; hes family bHLH transcription factor 1 K06054 HES1; hairy and enhancer of split 1
E 101702498 centromere protein S-like K11511 APITD1; centromere protein S
E 101722025 Cenpx; centromere protein X K15360 STRA13; centromere protein X
E 101714812 Ube2t; ubiquitin conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 101719260 Blm; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101708161 Top3b; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101706019 Top3a; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101718524 Rmi1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 101724407 Rmi2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 101705946 Fancd2; Fanconi anemia complementation group D2 K10891 FANCD2; fanconi anemia group D2 protein
E 101701516 Fanci; Fanconi anemia complementation group I K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 101705460 Brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101698015 Brca2; BRCA2, DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 101716733 Brip1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 101720121 Palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 101722565 Fan1; FANCD2 and FANCI associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 101715048 Rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 101714867 Rad51c; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 101712286 Telo2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
E 101716794 Usp1; ubiquitin specific peptidase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 101709412 Wdr48; WD repeat domain 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 101714279 Ppp6c; protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 101709601 Ppp6r1; protein phosphatase 6 regulatory subunit 1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 101701944 Ppp6r2; protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 101716981 Ppp6r3; protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 101718420 Ankrd28; ankyrin repeat domain 28 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 101707847 Ankrd44; ankyrin repeat domain 44 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 101711247 Ankrd52; ankyrin repeat domain 52 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 101703952 Rnf8; ring finger protein 8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 101708108 Rnf168; ring finger protein 168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 101719812 Rnf169; ring finger protein 169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 101713485 Herc2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 101702587 Wrap53; WD repeat containing antisense to TP53 K23314 WRAP53; telomerase Cajal body protein 1
E 101718444 Tprn; taperin K24164 TPRN; taperin
E 101720608 Zcwpw1; zinc finger CW-type and PWWP domain containing 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 101701259 Wdr70; WD repeat domain 70 K24752 WDR70; WD repeat-containing protein 70
E 101697052 Wdr76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 101708877 Polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 101707390 Poli; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 101718580 Polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 101699664 Rev1; REV1, DNA directed polymerase K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 101723274 Rev3l; REV3 like, DNA directed polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 101707096 Poln; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 101698111 Ube2a; ubiquitin conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 101706676 Ube2b; ubiquitin conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 101717786 Rad18; RAD18, E3 ubiquitin protein ligase K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 101700755 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 101719751 Hltf; helicase like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 101705426 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 106007575 Ube2v1; ubiquitin conjugating enzyme E2 V1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 101720592 Ube2v2; ubiquitin conjugating enzyme E2 V2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 101706436 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 101699785 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101709355 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101719536 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101718881 Ube2n; ubiquitin conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101722074 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101709837 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101697280 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101714303 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101700196 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101702692 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101708088 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101700426 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101702561 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 101716659 uncharacterized LOC101716659 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 101714005 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 101708284 Parpbp; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
D 101710243 Sprtn; SprT-like N-terminal domain K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 101714760 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 101705925 Gcna; germ cell nuclear acidic peptidase K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 101704571 Rad9a; RAD9 checkpoint clamp component A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 101716809 Rad9b; RAD9 checkpoint clamp component B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 101704977 Hus1; HUS1 checkpoint clamp component K10903 HUS1; HUS1 checkpoint protein
D 101715088 Rad1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 101720200 Rad17; RAD17 checkpoint clamp loader component K06662 HRAD17; cell cycle checkpoint protein
D 101697046 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 101719049 Rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 101710167 Rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 101723031 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 101715088 Rad1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 101706199 Timeless; timeless circadian clock K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 101716762 Tipin; TIMELESS interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 101713948 Clspn; claspin K25773 CLSPN; claspin
C Triple T complex
D 101712286 Telo2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
D 101700539 Tti1; TELO2 interacting protein 1 K20403 TTI1; TELO2-interacting protein 1
D 101719521 Tti2; TELO2 interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 101710313 Bag6; BCL2 associated athanogene 6 K23390 BAG6; large proline-rich protein BAG6
D 101708338 Ubl4a; ubiquitin like 4A K23388 UBL4; ubiquitin-like protein 4
D 101713490 Ubl4b; ubiquitin like 4B K23388 UBL4; ubiquitin-like protein 4
D 101701784 Get4; golgi to ER traffic protein 4 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 101701996 Atr; ATR serine/threonine kinase K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 101715729 Atrip; ATR interacting protein K10905 ATRIP; ATR interacting protein
D 101718948 Atm; ATM serine/threonine kinase K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 101701769 Tp53; tumor protein p53 K04451 TP53; tumor protein p53
D 101701035 Chek1; checkpoint kinase 1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 101721212 Chek2; checkpoint kinase 2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 101699133 Cdc25a; cell division cycle 25A K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 101701077 Cdc25b; cell division cycle 25B K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 101712931 Cdc25c; cell division cycle 25C K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 101720841 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101720117 Ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101721954 Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101705080 Ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101716439 Ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 101709704 Ywhah; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 101712650 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 101717238 Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 101723248 Nav2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 101706756 Wee2; WEE1 homolog 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 101704354 Wee1; WEE1 G2 checkpoint kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 101702827 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 101710492 Per1; period circadian clock 1 K21944 PER1; period circadian protein 1
D 101724066 Per2; period circadian clock 2 K02633 PER2; period circadian protein 2
D 101709352 Per3; period circadian clock 3 K21945 PER3; period circadian protein 3
D 101702518 Mdc1; mediator of DNA damage checkpoint 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 101724466 Pls3; plastin 3 K17336 PLS3; plastin-3
D 101726535 Aen; apoptosis enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 101702778 Plk3; polo like kinase 3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 101697228 Plk5; polo like kinase 5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 101696587 Nek4; NIMA related kinase 4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101703746 Nek1; NIMA related kinase 1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101711997 Nek5; NIMA related kinase 5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101698412 Nek10; NIMA related kinase 10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 101708450 Nek11; NIMA related kinase 11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 101696334 Donson; downstream neighbor of SON K22422 DONSON; protein downstream neighbor of Son
D 101702127 Kank1; KN motif and ankyrin repeat domains 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101704660 Kank2; KN motif and ankyrin repeat domains 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101716931 Kank3; KN motif and ankyrin repeat domains 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101720735 Kank4; KN motif and ankyrin repeat domains 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101701901 Klln; killin, p53-regulated DNA replication inhibitor K23389 KLLN; killin
D 101704056 Chmp4c; charged multivesicular body protein 4C K24782 CHMP4C; charged multivesicular body protein 4C
D 101716007 Vps4a; vacuolar protein sorting 4 homolog A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 101702359 Vps4b; vacuolar protein sorting 4 homolog B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 101718629 Zfyve19; zinc finger FYVE-type containing 19 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 101698702 Sde2; SDE2 telomere maintenance homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 101721523 Polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 101698788 Mybbp1a; MYB binding protein 1a K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 101703853 Primpol; primase and DNA directed polymerase K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 101715376 Trex1; three prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 101712412 Trex2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 101708258 Dclre1a; DNA cross-link repair 1A K15340 DCLRE1A; DNA cross-link repair 1A protein
D 101714533 Dclre1b; DNA cross-link repair 1B K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 101711319 Exo5; exonuclease 5 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 101723539 Endov; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 101726197 Zranb3; zinc finger RANBP2-type containing 3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 101698380 Ankle1; ankyrin repeat and LEM domain containing 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 101722327 Helq; helicase, POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 101716590 Ercc6l2; ERCC excision repair 6 like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 101719630 Prpf19; pre-mRNA processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 101726375 Cdc5l; cell division cycle 5 like K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 101718582 Bcas2; BCAS2, pre-mRNA processing factor K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 101726396 Plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 101705125 Nudt15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 101712324 Nudt1; nudix hydrolase 1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 101710430 Nudt18; nudix hydrolase 18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 101718828 Dut; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101708047 Rrm1; ribonucleotide reductase catalytic subunit M1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 101700655 Rrm2; ribonucleotide reductase regulatory subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 101718446 Rrm2b; ribonucleotide reductase regulatory TP53 inducible subunit M2B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 101714788 Mgmt; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 101717051 Ung; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 101709636 Smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 101707491 Mpg; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 101706875 Mutyh; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 101717895 Nthl1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 101707844 Ssbp1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 101707844 Ssbp1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 101705125 Nudt15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 101718828 Dut; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024