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Transfer RNA Biogenesis - Methanopyrus kandleri
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
D MK1216 pop4_2; RNAse P subunit P29 K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D MK0846 pop4_1; RNAse P subunit P29 K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D MK0386 pop5; Predicted exosome subunit, RNase P subunit P14 K03537 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
D MK0387 rpp30; Ribonuclease P subunit Rpp30 K03539 RPP1; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
D MK1622 rpr2; RNAse P subunit RPR2 K03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D MK1033 Metal-dependent hydrolase of the beta-lactamase superfamily K00784 rnz; ribonuclease Z [EC:3.1.26.11]
C CCA adding factors
B tRNA spricing factors
C tRNA splicing endonuclease complex
C tRNA splicing ligase complex
D MK1682 rtcB; Uncharacterized conserved protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D MK0228 Uncharacterized conserved protein K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
D MK0247 GTPase, translation elongation factor K03231 EEF1A; elongation factor 1-alpha
C tRNA import factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D MK0757 glnS; Glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D MK1229 proS; Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D MK0899 ileS; Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D MK1364 leuS; Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MK0850 metG; Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D MK0758 argS; Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
C Other AARSs
D MK0900 alaS; Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D MK0152 grs1; Glycyl-tRNA synthetase, class II K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]
D MK0544 thrS; Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D MK1460 serS; Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D MK1424 valS; Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D MK1538 hisS; Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D MK0271 pheS; Phenylalanyl-tRNA synthetase alpha subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D MK0820 pheT; Phenylalanyl-tRNA synthetase beta subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D MK0516 tyrS; Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MK0343 trpS; Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D MK0939 Uncharacterized protein conserved in archaea K09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
C AARS associated factors
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
C Methylthiotransferase
D MK1081 miaB; 2-methylthioadenine synthetase K15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 [EC:2.8.4.5]
C Methyltransferases
D MK0154 trm1_1; N2,N2-dimethylguanosine tRNA methyltransferase K00555 TRMT1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D MK0189 trm1_2; N2,N2-dimethylguanosine tRNA methyltransferase K00555 TRMT1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D MK0599 Predicted methyltransferase K15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D MK1415 Predicted SAM-dependent methyltransferase involved in tRNA-Met maturation K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D MK0151 Uncharacterized conserved protein K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D MK0055 Fe-S oxidoreductase K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D MK0940 Predicted SAM-dependent methyltransferase K07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]
D MK0048 Uncharacterized conserved protein K15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]
C Psudouridine synthases
D MK0888 truA; Pseudouridylate synthase of the TruA family K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D MK0133 truB; Pseudouridine synthase of the TruB family K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D MK0676 Uncharacterized conserved protein K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D MK1646 Predicted pseudouridylate synthase K07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]
C Thiolation factors
C KEOPS/EKC complex
D MK1456 Mn2+-dependent serine/threonine protein kinase K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D MK1458 qri7; Metal-dependent protease with possible chaperone activity K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
C Elongator complex
D MK1052 elp3; ELP3 component of the RNA polymerase II complex, consists of an N-terminal BioB/LipA-like domain and a C-terminal histone acetylase domain K07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]
C Elongator related proteins
C Other tRNA modification factors
D MK0635 sua5; Translation factor (SUA5) K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D MK1369 selD; Predicted enzyme related to selenophosphate synthase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D MK1462 Predicted RNA-binding protein, contains THUMP domain K06963 TAN1; tRNA acetyltransferase TAN1
D MK0344 Predicted 23S rRNA methylase containing THUMP domain K06963 TAN1; tRNA acetyltransferase TAN1
D MK0402 Predicted RNA-binding protein containing THUMP domain K06963 TAN1; tRNA acetyltransferase TAN1
D MK0093 Uncharacterized conserved protein K10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]
B tRNA degradation factors
C TRAMP complex
C Rapid tRNA decay (RTD) pathway factors
C Other tRNA degradation factors
#
AProkaryotic type
B 5'processing factors
C Ribonucrease P
D MK1237 Uncharacterized conserved protein K09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D MK1033 Metal-dependent hydrolase of the beta-lactamase superfamily K00784 rnz; ribonuclease Z [EC:3.1.26.11]
C CCA adding factors
D MK1366 cca1; tRNA nucleotidyltransferase (CCA-adding enzyme) K07558 K07558; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]
B tRNA spricing factors
C tRNA splicing endonucleases
D MK0341 sen2_1; tRNA splicing endonuclease K01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]
D MK0397 sen2_2; tRNA splicing endonuclease K01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]
C tRNA splicing ligases
D MK1682 rtcB; Uncharacterized conserved protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
D MK1367 ligT; 2'-5' RNA ligase K01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]
D MK1434 kptA; RNA:NAD 2'-phosphotransferase K07559 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-]
B tRNA transport factors
C tRNA export factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D MK1364 leuS; Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MK0986 lysS; Lysyl-tRNA synthetase (class I) K04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]
D MK1229 proS; Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D MK0516 tyrS; Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MK0343 trpS; Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D MK0544 thrS; Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D MK0899 ileS; Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D MK0900 alaS; Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D MK1424 valS; Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D MK0850 metG; Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D MK1460 serS; Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D MK1187 Predicted extracellular polysaccharide hydrolase of the endo alpha-1,4 polygalactosaminidase family K01884 cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]
D MK1125 Predicted extracellular polysaccharide hydrolase of the Endo alpha-1,4 polygalactosaminidase family K01884 cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]
D MK1100 Predicted extracellular polysaccharide hydrolase of the endo alpha-1,4 polygalactosaminidase family K01884 cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]
D MK0757 glnS; Glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D MK0758 argS; Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D MK0271 pheS; Phenylalanyl-tRNA synthetase alpha subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D MK0820 pheT; Phenylalanyl-tRNA synthetase beta subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D MK1538 hisS; Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D MK0710 asnS; Aspartyl-tRNA synthetase K09759 aspC; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]
D MK0439 Phenylalanyl-tRNA synthetase alpha subunit, archaeal type K07587 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]
D MK0229 Archaea-specific pyridoxal phosphate-dependent enzyme K06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]
C Trans-editing factors
D MK0939 Uncharacterized protein conserved in archaea K09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D MK1555 Uncharacterized protein K19055 prdX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]
B tRNA modification factors
C Deaminases
D MK0935 Predicted RNA-binding protein, contains THUMP domain K16930 cdat8; tRNA(cytosine8) deaminase [EC:3.5.4.35]
C Dihydorouridine synthases
C Methylthiotransferases
D MK0797 Predicted Fe-S oxidoreductase K06168 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
D MK0932 Fe-S oxidoreductase family protein K06168 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
C Methyltransferases
D MK0519 lasT; rRNA methylase K02533 lasT; tRNA/rRNA methyltransferase [EC:2.1.1.-]
D MK0151 Uncharacterized conserved protein K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D MK1018 Uncharacterized conserved protein K16317 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257]
D MK0370 tRNA/rRNA cytosine-C5-methylase K22901 trm4; tRNA (cytosine40_48-C5)-methyltransferase [EC:2.1.1.-]
D MK0673 tRNA/rRNA cytosine-C5-methylase K22901 trm4; tRNA (cytosine40_48-C5)-methyltransferase [EC:2.1.1.-]
D MK1026 Uncharacterized conserved protein K15566 trm10; tRNA (adenine9-N1/guanine9-N1)-methyltransferase [EC:2.1.1.218 2.1.1.221]
D MK0969 Predicted N6-adenine-specific RNA methylase containing THUMP domain K16318 trm14; tRNA (guanine6-N2)-methyltransferase [EC:2.1.1.256]
D MK0894 Predicted DNA-modification methylase K07446 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213]
D MK0803 SpoU-like RNA methylase K07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]
C Psudouridine synthases
D MK0888 truA; Pseudouridylate synthase of the TruA family K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D MK0133 truB; Pseudouridine synthase of the TruB family K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D MK0676 Uncharacterized conserved protein K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D MK0144 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control K21947 ttuA; tRNA-5-methyluridine54 2-sulfurtransferase [EC:2.8.1.15]
D MK0257 Predicted redox protein, regulator of disulfide bond formation K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
C KEOPS/EKC complex
D MK1456 Mn2+-dependent serine/threonine protein kinase K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D MK1458 qri7; Metal-dependent protease with possible chaperone activity K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D MK0270 Uncharacterized conserved protein K09119 cgi121; KEOPS complex subunit Cgi121
D MK0376 Uncharacterized protein conserved in archaea K09741 pcc1; KEOPS complex subunit Pcc1
C Other tRNA modification factors
D MK1065 Predicted PP-loop superfamily ATPase K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D MK0819 6-pyruvoyl-tetrahydropterin synthase K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D MK0818 Organic-radical-activating enzyme K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D MK1369 selD; Predicted enzyme related to selenophosphate synthase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D MK0188 tgt; Queuine/archaeosine tRNA-ribosyltransferase K18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]
D MK0908 thiI_2; ATP pyrophosphatase involved in thiamine biosynthesis K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D MK0778 thiI_1; Thiamine biosynthesis ATP pyrophosphatase K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D MK1003 Predicted DNA-binding protein containing a Zn-ribbon K06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]
D MK0146 Predicted P-loop ATPase fused to an acetyltransferase K06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]
D MK0635 sua5; Translation factor (SUA5) K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
B tRNA degradation factors
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024